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Production of insulin producing cells

  • US 9,624,472 B2
  • Filed: 05/18/2015
  • Issued: 04/18/2017
  • Est. Priority Date: 06/17/2010
  • Status: Active Grant
First Claim
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1. A method to provide pancreatic cells to a subject in need thereof comprising:

  • a) contacting the stem cells with at least one member of the TGFβ

    family of cytokines and at least one member of the Wnt family of proteins, wherein the stem cells are induced pluripotent stem (iPS) cells,b) contacting the cells obtained from step a) with at least one member of the TGFβ

    family of cytokines, at least one member of the Wnt family of proteins, and an agent that inhibits sonic hedgehog activity; and

    c) contacting the cells obtained from step b) with a member of the Epidermal growth factor (EGF) family of proteins; and

    administering the cells so as to provide pancreatic cells in the subject.

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