Methods and compositions for regulation of zinc finger protein expression
First Claim
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1. A construct comprising a polynucleotide encoding at least one component of a non-naturally occurring gene modulator that binds to an intended target site, wherein the polynucleotide is operably linked to a heterologous promoter comprising a self-regulating target site bound by the gene modulator and further wherein binding of the gene modulator to the self-regulating target sequence modulates expression of the polynucleotide.
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Abstract
The present disclosure is in the field of genome engineering, particularly regulating targeted modification of the genome.
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22 Claims
- 1. A construct comprising a polynucleotide encoding at least one component of a non-naturally occurring gene modulator that binds to an intended target site, wherein the polynucleotide is operably linked to a heterologous promoter comprising a self-regulating target site bound by the gene modulator and further wherein binding of the gene modulator to the self-regulating target sequence modulates expression of the polynucleotide.
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