Method, apparatus, and article to facilitate evaluation of objects using electromagnetic energy

• US 9,625,371 B2
• Filed: 02/23/2015
• Issued: 04/18/2017
• Est. Priority Date: 07/31/2006
• Status: Active Grant

• Current Assignee: Visulant, Inc.
• Original Assignee: Visulant, Inc.
• Inventors: Furness, III, Thomas A., Schowengerdt, Brian T., Melville, Ross D., Walker, Nicholas E., Sparks, Bradley E.
• Primary Examiner(s): Stafira, Michael P
• Application Number:
  US14/629,155
• Publication Number:
  US 20150241338A1
• Time in Patent Office: 785 Days
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: G01J 3/02 Details
• CPC Class Codes: G01J 3/0264 Electrical interface; User interface
• CPC Class Codes: G01J 3/10 Arrangements of light sources specially adapted for spectrometry or colorimetry
• CPC Class Codes: G01J 3/42 Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01J 3/46 Measurement of colour; Colour measuring devices, e.g. colorimeters measuring colour temperature G01J5/60
• CPC Class Codes: G01J 3/463 Colour matching
• CPC Class Codes: G01J 3/50 using electric radiation detectors
• CPC Class Codes: G01J 3/501 Colorimeters using spectrally-selective light sources, e.g. LEDs
• CPC Class Codes: G01N 21/255 Details, e.g. use of specially adapted sources, lighting or optical systems
• CPC Class Codes: G01N 21/27 using photo-electric detection G01N21/31 takes precedence; circuits for computing concentration logarithmic circuits G06G7/24; photometric circuits in general G01J
• CPC Class Codes: G01N 2201/06113 Coherent sources; lasers
• CPC Class Codes: G01N 2201/062 LED's
• CPC Class Codes: G01N 33/4833 of solid biological material, e.g. tissue samples, cell cultures tissue in vivo A61B5/00; cell suspensions G01N33/48735

Abstract

Spectral information may be employed in process control and/or quality control of goods and articles. Spectral information may be employed in process control and/or quality control of media, for example financial instruments, identity documents, legal documents, medical documents, financial transaction cards, and/or other media, fluids for example lubricants, fuels, coolants, or other materials that flow, and in machinery, for example vehicles, motors, generators, compressors, presses, drills and/or supply systems. Spectral information may be employed in identifying biological tissue and/or facilitating diagnosis based on biological tissue.

Claims

1. A method of evaluating biological tissue, the method comprising:

during a first period, sequentially illuminating using one or more sources at least a first portion of a biological tissue being evaluated with a plurality of bands of electromagnetic energy in a first sequence, wherein at least one of the sources provides two or more of the plurality of bands of electromagnetic energy;

during the first period, measuring a plurality of responses to the illumination from at least the first portion of the biological tissue being evaluated;

comparing the measured responses of the first period to a first set of reference responses to illumination of a reference specimen of biological tissue; and

identifying the portion of biological tissue based at least in part on the comparison of the measured responses of the first period to the first set of reference responses.

3. The method of claim 1, further comprising:

during a second period, sequentially illuminating at least a second portion of the biological tissue being evaluated with a plurality of bands of electromagnetic energy in the first sequence;

during the second period, measuring a plurality of responses to the illumination from at least the second portion of the biological tissue being evaluated;

comparing the measured responses of the second period to a second set of reference responses to illumination of the reference specimen of biological tissue; and

identifying the portion of biological tissue based at least in part on the comparison of the measured responses of the second period to the second set of reference responses.

4. The method of claim 1 further comprising:

during a second period, sequentially illuminating at least the first portion of the biological tissue being evaluated with a plurality of bands of electromagnetic energy in a second sequence, the second sequence different from the first sequence;

during the second period, measuring a plurality of responses to the illumination from at least the first portion of the biological tissue being evaluated;

comparing the measured responses of the second period to a second set of reference responses to illumination of the reference specimen of biological tissue; and

identifying the portion of biological tissue being evaluated based at least in part on the comparison of the measured responses of the second period to the second set of reference responses.

5. The method of claim 1 wherein sequentially illuminating at least a first portion of a biological tissue being evaluated with a plurality of bands of electromagnetic energy in a first sequence includes sequentially illuminating at least the first portion of the biological tissue being evaluated with electromagnetic energy from bands within a visible portion, an infrared portion or an ultraviolet portion of the electromagnetic spectrum.

6. The method of claim 1 wherein sequentially illuminating at least a first portion of a biological tissue being evaluated with a plurality of bands of electromagnetic energy in a first sequence includes selectively turning respective ones of the one or more sources ON and OFF in an order defined by the first sequence.

7. The method of claim 6 wherein selectively turning respective ones of the sources ON and OFF in an order defined by the first sequence includes selectively applying current to respective ones of the sources in the order defined by the first sequence.

8. The method of claim 6 wherein selectively turning respective ones of the sources ON and OFF in an order defined by the first sequence includes selectively applying current at a plurality of different levels to respective ones of the sources, where the order and the level is defined by the first sequence.

9. The method of claim 8 wherein selectively applying current at a plurality of different levels to respective ones of the sources, where the order and the level is defined by the first sequence includes selectively applying current at the plurality of different levels to respective ones of a plurality of light emitting diodes, at least some of the light emitting diodes having an emission spectra at a first current level that differs from an emission spectra of other of the light emitting diodes at the first current level.

11. The method of claim 1, further comprising:

receiving additional data indicative of at least one of a measurable or an observable bodily characteristic of a subject to which the biological tissue derives, and wherein identifying the portion of biological tissue is based at least in part on the additional data.

2. A method of evaluating biological tissue, the method comprising:

during a first period, sequentially illuminating at least a first portion of a biological tissue being evaluated with a plurality of bands of electromagnetic energy in a first sequence;

during the first period, measuring a plurality of responses to the illumination from at least the first portion of the biological tissue being evaluated;

comparing the measured responses of the first period to a first set of reference responses to illumination of a reference specimen of biological tissue;

identifying the portion of biological tissue based at least in part on the comparison of the measured responses of the first period to the first set of reference responses;

during a second period, sequentially illuminating at least a second portion of the biological tissue being evaluated with a plurality of bands of electromagnetic energy;

during the second period, measuring a plurality of responses to the illumination from at least the second portion of the biological tissue being evaluated;

comparing the measured responses of the second period to a second set of reference responses to illumination of the reference specimen of biological tissue; and

identifying the portion of the biological tissue based at least in part on the comparison of the measured responses of the second period to the second set of reference responses.

10. The method of claim 2 wherein identifying a portion of biological tissue based at least in part on the comparison of the measured responses of the second period to the second set of reference responses includes classifying the portion of biological tissue.

12. A method of facilitating diagnosis using biological tissues, the method comprising:

during a first period, sequentially illuminating using one or more sources at least a first portion of a biological tissue with a plurality of bands of electromagnetic energy in a first sequence, wherein at least one of the sources provides at least two of the bands of electromagnetic energy in the plurality of bands;

during the first period, measuring a plurality of responses to the illumination from at least the first portion of the biological tissue;

comparing the measured responses of the first period to a first set of reference responses to illumination of a reference specimen of biological tissue; and

diagnosing at least the first portion of biological tissue based at least in part on the comparison of the measured responses of the first period to the first set of reference responses.

14. The method of claim 12, further comprising:

during a second period, sequentially illuminating at least the first portion of the biological tissue being evaluated with a plurality of bands of electromagnetic energy in a second sequence, the second sequence different from the first sequence;

during the second period, measuring a plurality of responses to the illumination from at least the first portion of the biological tissue being evaluated;

comparing the measured responses of the second period to a second set of reference responses to illumination of the reference specimen of biological tissue; and

diagnosing the portion of biological tissue being evaluated based at least in part on the comparison of the measured responses of the second period to the second set of reference responses.

15. The method of claim 12 wherein sequentially illuminating at least a first portion of a biological tissue being evaluated with a plurality of bands of electromagnetic energy in a first sequence includes sequentially illuminating at least the first portion of the biological tissue being evaluated with electromagnetic energy from bands within a visible portion, an infrared portion or an ultraviolet portion of the electromagnetic spectrum.

16. The method of claim 12 wherein sequentially illuminating at least a first portion of a biological tissue being evaluated with a plurality of bands of electromagnetic energy in a first sequence includes selectively turning respective ones of the one or more sources ON and OFF in an order defined by the first sequence.

17. The method of claim 16 wherein selectively turning respective ones of the sources ON and OFF in an order defined by the first sequence includes selectively applying current at a plurality of different levels to respective ones of the sources, where the order and the level is defined by the first sequence and at least some of the sources have an emission spectra at a first current level that differs from an emission spectra of other of the sources at the first current level.

18. The method of claim 12 wherein comparing the measured responses of the first period to a first set of reference responses to illumination of a reference specimen of biological tissue includes comparing the measured responses of the first period to the set of reference responses to illumination of a normal specimen of biological tissue.

19. The method of claim 12 wherein comparing the measured responses of the first period to a first set of reference responses to illumination of a reference specimen of biological tissue includes comparing the measured responses of the first period to the set of reference responses to illumination of an abnormal specimen of biological tissue.

20. The method of claim 12, further comprising:

receiving additional data concerning the biological tissue being evaluated, and wherein identifying the portion of biological tissue is based at least in part on the additional data.

21. The method of claim 20 wherein receiving additional data concerning the biological tissue being evaluated includes receiving data indicative of at least one of a measurable or observable bodily characteristic of a subject to which the biological tissue derives.

22. The method of claim 21, further comprising:

providing a query for the additional data.

23. The method of claim 12 wherein sequentially illuminating at least a first portion of a biological tissue with a plurality of bands of electromagnetic energy in a first sequence includes sequentially illuminating at least a first portion of a bodily fluid with the plurality of bands of electromagnetic energy in the first sequence.

24. The method of claim 23 wherein sequentially illuminating at least a first portion of a bodily fluid with the plurality of bands of electromagnetic energy in the first sequence includes sequentially illuminating at least a first portion of blood with the plurality of bands of electromagnetic energy in the first sequence.

25. The method of claim 24 wherein sequentially illuminating at least a first portion of blood with the plurality of bands of electromagnetic energy in the first sequence includes sequentially illuminating at least the first portion of blood in vivo with the plurality of bands of electromagnetic energy in the first sequence.

26. The method of claim 24 wherein diagnosing at least the first portion of biological tissue based at least in part on the comparison of the measured responses of the first period to the first set of reference responses includes comparing the spectral responses from the first period to the first set of reference responses to illumination of a reference specimen of blood with a known blood sugar level.

13. A method of facilitating diagnosis using biological tissues, the method comprising:

during a first period, sequentially illuminating at least a first portion of a biological tissue with a plurality of bands of electromagnetic energy in a first sequence;

during the first period, measuring a plurality of responses to the illumination from at least the first portion of the biological tissue;

comparing the measured responses of the first period to a first set of reference responses to illumination of a reference specimen of biological tissue;

diagnosing at least the first portion of biological tissue based at least in part on the comparison of the measured responses of the first period to the first set of reference responses;

during a second period, sequentially illuminating at least a second portion of the biological tissue being evaluated with a plurality of bands of electromagnetic energy;

during the second period, measuring a plurality of responses to the illumination from at least the second portion of the biological tissue being evaluated;

comparing the measured responses of the second period to a second set of reference responses to illumination of the reference specimen of biological tissue; and

diagnosing the portion of the biological tissue based at least in part on the comparison of the measured responses of the second period to the second set of reference responses.

27. A system useful in evaluating biological tissue, the system comprising:

means for sequentially illuminating at least a first portion of a biological tissue with a plurality of bands of electromagnetic energy in a sequence that may be varied from time-to-time, wherein at least one of the means for sequentially illuminating provides two or more of the plurality of bands of electromagnetic energy;

means for measuring a plurality of responses to the illumination from at least the first portion of the biological tissue being evaluated; and

means for identifying the biological tissue based at least in part on a comparison of the measured responses to a set of reference responses and based on the sequence of illumination.

28. The system of claim 27 wherein the means for sequentially illuminating includes at least a first source operable to emit electromagnetic energy in a first band at a first time and in a second band at a second time, the second band being at least partially different from the first band.

29. The system of claim 27 wherein the means for sequentially illuminating includes a plurality of sources each operable to emit electromagnetic energy in a respective band, at least one of the bands being at least partially different from another one of the bands.

30. The system of claim 27 wherein the means for measuring a plurality of responses to the illumination includes at least one sensor selected from the group consisting of a photodiode, a photomultiplier, a charge-coupled device, and a multi-channel plate.

31. The system of claim 27 wherein the means for identifying the biological tissue is remote from the means for sequentially illuminating.

32. A system useful in evaluating biological tissue, the system comprising:

means for sequentially illuminating at least a first portion of a biological tissue with a plurality of bands of electromagnetic energy in a sequence that may be varied from time-to-time, wherein at least one of the means for sequentially illuminating provides two or more of the plurality of bands of electromagnetic energy;

means for measuring a plurality of responses to the illumination from at least the first portion of the biological tissue being evaluated; and

means for diagnosing at least the first portion of biological tissue based at least in part on a comparison of the measured responses to a set of reference responses and based on the sequence of illumination.

33. The system of claim 32 wherein the means for sequentially illuminating includes at least a first source operable to emit electromagnetic energy in a first band at a first time and in a second band at a second time, the second band being at least partially different from the first band.

34. The system of claim 32 wherein the means for sequentially illuminating includes a plurality of sources each operable to emit electromagnetic energy in a respective band, at least one of the bands being at least partially different from another one of the bands.

35. The system of claim 32 wherein the means for measuring a plurality of responses to the illumination includes at least one sensor selected from the group consisting of a photodiode, a photomultiplier, a charge-coupled device, and a multi-channel plate.

36. The system of claim 32, further comprising:

means for acquiring additional information, wherein the means for diagnosing at least the first portion of biological tissue employs the additional information in forming a diagnosis.