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Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

  • US 9,625,415 B2
  • Filed: 05/13/2016
  • Issued: 04/18/2017
  • Est. Priority Date: 06/08/2012
  • Status: Active Grant
First Claim
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1. A method of calculating a single, fused sensor glucose value based on respective glucose measurement signals of a plurality of redundant sensing electrodes, comprising:

  • performing respective electrochemical impedance spectroscopy (EIS) procedures for each of the plurality of redundant sensing electrodes to obtain values of at least one impedance-based parameter for each said sensing electrode;

    measuring the electrode current (Isig) for each of the plurality of redundant sensing electrodes;

    calibrating each of the measured Isigs to obtain respective calibrated sensor glucose values;

    calculating a bound-check reliability index and a noise-check reliability index for each said sensing electrode based on said measured Isig and said values of the at least one impedance-based parameter;

    calculating a dip reliability index for each said sensing electrode based on one or more of said at least one impedance-based parameter;

    calculating a sensitivity-loss reliability index for each said sensing electrode based on one or more of said at least one impedance-based parameter; and

    calculating said single, fused sensor glucose value based on the respective bound-check reliability index, noise-check reliability index, dip reliability index, sensitivity-loss reliability index and calibrated sensor glucose values of each of the plurality of redundant sensing electrodes.

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