Imaging systems with movable scan mirrors
First Claim
Patent Images
1. An imaging system comprising:
- a camera with a two dimensional full-frame electronic sensor;
an objective lens component configured to project an image of at least a two-dimensional portion of a substrate onto the two dimensional full-frame electronic sensor of the camera to produce a two-dimensional image;
a positioning stage configured to move in continuous motion the substrate in a first known lateral direction with respect to the objective lens component while the camera with the two dimensional full-frame electronic sensor produces the two-dimensional image;
a scan mirror configured to tilt relative to a viewing axis between the two dimensional full-frame electronic sensor and the substrate in continuous motion in coordination with the moving positioning stage, while the positioning stage moves the substrate in the first known lateral direction, in order to reflect light from the objective lens component to the camera while maintaining the substrate image stable at the electronic sensor;
a first tilt plate positioned in an optical path between the scan mirror and the camera, wherein the first tilt plate is configured to cause first offset corrections to the substrate image that is acquired by the objective lens component; and
a second tilt plate positioned in the optical path between the scan mirror and the camera, wherein the second tilt plate is configured to cause second offset corrections, in the substrate image in a second direction that is perpendicular to the first offset corrections.
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Abstract
An imaging system is provided wherein a positioning stage is translated with respect to an objective lens component and a scan mirror is repositioned while a two-dimensional image is made of a biochemical site on a substrate. In an example embodiment, an imaging system comprises a camera, an objective lens component, a positioning stage, and a scan mirror controllable by a servo system that synchronizes movement of the positioning stage and the tilting of the scan mirror so that the substrate image is maintained stable during imaging of the continuously moving positioning stage.
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Citations
12 Claims
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1. An imaging system comprising:
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a camera with a two dimensional full-frame electronic sensor; an objective lens component configured to project an image of at least a two-dimensional portion of a substrate onto the two dimensional full-frame electronic sensor of the camera to produce a two-dimensional image; a positioning stage configured to move in continuous motion the substrate in a first known lateral direction with respect to the objective lens component while the camera with the two dimensional full-frame electronic sensor produces the two-dimensional image; a scan mirror configured to tilt relative to a viewing axis between the two dimensional full-frame electronic sensor and the substrate in continuous motion in coordination with the moving positioning stage, while the positioning stage moves the substrate in the first known lateral direction, in order to reflect light from the objective lens component to the camera while maintaining the substrate image stable at the electronic sensor; a first tilt plate positioned in an optical path between the scan mirror and the camera, wherein the first tilt plate is configured to cause first offset corrections to the substrate image that is acquired by the objective lens component; and a second tilt plate positioned in the optical path between the scan mirror and the camera, wherein the second tilt plate is configured to cause second offset corrections, in the substrate image in a second direction that is perpendicular to the first offset corrections. - View Dependent Claims (2, 3, 4, 5)
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6. An imaging system comprising:
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an objective lens component that projects an array chip image of an array chip containing biochemical materials onto a full frame two-dimensional electronic sensor of a camera; a scan mirror, capable of angular motion, that reflects light from the objective lens component to the two dimensional full-frame electronic sensor; a positioning stage that moves the array chip in a known lateral direction with respect to the objective lens component and in coordination with the scan mirror for maintaining a stable image of the array chip at the two dimensional full-frame electronic sensor during continuous movement of the positioning stage while the camera images the array chip containing biochemical materials; a first tilt plate between the scan mirror and the camera, the first tilt plate providing first image offset corrections; and a second tilt plate between the scan mirror and the camera, the second tilt plate providing second image offset corrections in a direction perpendicular to the first image offset corrections. - View Dependent Claims (7, 8, 9, 10, 11, 12)
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Specification