Prefilled syringe jet injector

• US 9,629,959 B2
• Filed: 07/13/2016
• Issued: 04/25/2017
• Est. Priority Date: 01/24/2005
• Status: Active Grant

• Current Assignee: Antares Pharma Incorporated
• Original Assignee: Antares Pharma Incorporated
• Inventors: Lesch, Paul R.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): STILES, AMBER R.
• Application Number:
  US15/209,389
• Publication Number:
  US 20160317746A1
• Time in Patent Office: 286 Days
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 5/178 Syringes
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion
• CPC Class Codes: A61M 5/484 Regulating injection pressure

Abstract

A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.

Claims

1. An injector, comprising:

a prefilled syringe comprising;

a container portion defining a fluid chamber containing a medicament;

an injection-assisting needle disposed at the distal end of the fluid chamber having an injecting tip configured for piercing an insertion location and defining a fluid pathway in fluid communication with the fluid chamber; and

a plunger movable within the fluid chamber;

a housing that houses the prefilled syringe and comprises a guard that is movable with respect to the housing;

a syringe support supportively mounting the prefilled syringe to the housing; and

an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber that substantially remains from about 80 p.s.i. to about 1000 p.s.i. during injection of the medicament to inject the medicament from the fluid chamber through the needle,

wherein a penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament.

2. The injector of claim 1, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains from about 500 p.s.i. to about 90 p.s.i. during the injection of the medicament.

3. The injector of claim 1, wherein the energy source is configured to produce the injecting pressure that remains at a minimum of about 100 p.s.i. during the injection of the medicament.

4. The injector of claim 3, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains at a maximum of about 350 p.s.i. during the injection of the medicament.

5. The injector of claim 1, wherein the guard comprises a distal surface and is configured to allow the needle to extend beyond the distal surface at a maximum distance of about 15 mm.

6. The injector of claim 1, wherein the guard comprises a distal surface and is configured to allow the needle to extend beyond the distal surface at a distance from about 10 mm to about 14 mm.

7. The injector of claim 1, wherein the energy source comprises a spring.

8. The injector of claim 1, further comprising a ram that is biased by the spring against the plunger to produce the injecting pressure, wherein the ram comprises a bell portion on which the spring is seated, and the bell portion defines a hollow interior configured for receiving the prefilled syringe when the device is fired.

9. The injector of claim 1, wherein:

the prefilled syringe has a distal portion in which the injection-assisting needle is located, and a proximal portion opposite the distal portion; and

the syringe support axially supports the proximal portion of the pre-filled syringe during the injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axial direction.

10. The injector of claim 9, wherein the container portion of the pre-filled syringe is made of blown glass.

11. The injector of claim 10, wherein the injection-assisting needle is adhered to the glass.

12. The injector of claim 1, wherein the chamber contains from about 0.02 mL to about 4 mL of the medicament.

13. The injector of claim 1, wherein the guard is movable between:

a protecting position in which the needle is disposed within the guard; and

an injecting position in which the injecting tip of the needle is exposed for insertion to an insertion point.

14. The injector of claim 13, further comprising a trigger mechanism operably associated with the energy source for activating the energy source to inject the medicament, wherein the trigger mechanism is configured for activating the energy source after the guard is moved from the protecting position.

15. The injector of claim 14, wherein the guard is operably associated with the trigger mechanism to cause the trigger mechanism to activate the energy source when the guard is moved to the injecting position.

16. The injector of claim 1, further comprising a syringe cushion associated with the syringe support and prefilled syringe to compensate for shape.

22. The injector of claim 1, wherein the injector is a jet injector.

23. The injector of claim 1, wherein the injector is not a jet injector.

26. The injector of claim 1, wherein the injector is an autoinjector.

27. The injector of claim 1, wherein the fluid pathway is configured to inject fluid from the fluid chamber into an injection site.

17. An injector, comprising:

a prefilled syringe comprising;

a container portion defining a fluid chamber containing a medicament;

an injection-assisting needle disposed at the distal end of the fluid chamber having an injecting tip configured for piercing an insertion location and defining a fluid pathway in fluid communication with the fluid chamber; and

a plunger movable within the fluid chamber;

a housing that houses the prefilled syringe and is configured for allowing insertion of the needle at the insertion location to an insertion point that is at a maximum penetration depth of about 15 mm below the surface at the insertion location;

a syringe support fixed to the housing and supportively mounting the prefilled syringe to the housing; and

an energy source configured for biasing the plunger with a force selected to produce an injecting pressure in the medicament in the fluid chamber that substantially remains from about 80 p.s.i. to about 1000 p.s.i. during injection of the medicament, wherein a penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament.

18. The injector of claim 17, wherein the insertion point is at a penetration depth of about 1 mm to about 4 mm below the surface at the insertion location.

19. The injector of claim 17, wherein the insertion point is at a penetration depth of about 3 mm below the surface at the insertion location.

20. The injector of claim 17, wherein the injecting pressure and penetration depth are sufficient such that an injection site is subcutaneous.

21. The injector of claim 17, wherein the energy source and prefilled syringe are configured such that the injecting pressure remains from a maximum of about 500 p.s.i. to a minimum of about 90 p.s.i. during the injection of the medicament.

24. The injector of claim 17, wherein the injector is a jet injector.

25. The injector of claim 17, wherein the injector is not a jet injector.

28. The injector of claim 17, wherein the fluid pathway is configured to inject fluid from the fluid chamber into an injection site.

29. The injector of claim 17, wherein the syringe support is axially fixed to the housing.

30. The injector of claim 17 further comprising:

a syringe cushion associated with the syringe support and configured to support the prefilled syringe in the syringe support.

31. The injector of claim 18, wherein the penetration depth and injecting pressure are sufficient to substantially prevent backflow of the injected medicament from the insertion location back into the needle.

32. The injector of claim 17, wherein:

the prefilled syringe has a distal portion in which the injection-assisting needle is located, and a proximal portion opposite the distal portion; and

the syringe support axially supports the proximal portion of the pre-filled syringe during the injection of the medicament, such that the distal portion of the prefilled syringe is substantially unsupported in an axial direction.