Multilayered woven manufacture and use of the multilayer woven manufacture as carriers for dried matrix spot applications

• US 9,630,374 B2
• Filed: 12/21/2012
• Issued: 04/25/2017
• Est. Priority Date: 12/22/2011
• Status: Expired due to Fees

• Current Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Original Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Inventors: Mengerink, Ynze, Mommers, Johannes Helena Michael, Qiu, Jun
• Primary Examiner(s): Vonch, Jeff
• Application Number:
  US14/368,178
• Publication Number:
  US 20150004360A1
• Time in Patent Office: 1,586 Days
• Field of Search: None
• CPC Class Codes: B01J 20/28023 Fibres or filaments fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence
• CPC Class Codes: B01J 20/28033 Membrane, sheet, cloth, pad, lamellar or mat
• CPC Class Codes: B01J 20/28035 with more than one layer, e.g. laminates, separated sheets
• CPC Class Codes: B01J 20/28038 Membranes or mats made from fibers or filaments
• CPC Class Codes: B01J 20/28052 Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 20/28054 characterised by their surface properties or porosity
• CPC Class Codes: B01J 20/28095 Shape or type of pores, voids, channels, ducts
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/069 Absorbents; Gels to retain a fluid
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0874 Three dimensional network
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: B32B 2250/20 All layers being fibrous or filamentary
• CPC Class Codes: B32B 2262/0276 Polyester fibres
• CPC Class Codes: B32B 2307/728 Hydrophilic
• CPC Class Codes: B32B 5/024 Woven fabric
• CPC Class Codes: B32B 5/12 characterised by the relative arrangement of fibres or filaments of different layers, e.g. the fibres or filaments being parallel or perpendicular to each other
• CPC Class Codes: B32B 5/26 another layer next to it also being fibrous or filamentary relative arrangement of fibres or filaments of different layers B32B5/12
• CPC Class Codes: G01N 33/48 : Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02
• CPC Class Codes: G01N 33/5302 : Apparatus specially adapted for immunological test procedures
• CPC Class Codes: Y10T 428/24074 : Strand or strand-portions
• CPC Class Codes: Y10T 428/24091 : with additional layer[s]
• CPC Class Codes: Y10T 428/24099 : On each side of strands or strand-portions
• CPC Class Codes: Y10T 428/24107 : including mechanically interengaged strands, strand-portions or strand-like strips
• CPC Class Codes: Y10T 428/24124 : Fibers
• CPC Class Codes: Y10T 428/24132 : including grain, strips, or filamentary elements in different layers or components parallel
• CPC Class Codes: Y10T 428/24322 : Composite web or sheet
• CPC Class Codes: Y10T 428/24967 : Absolute thicknesses specified
• CPC Class Codes: Y10T 442/153 : Including an additional scrim layer
• CPC Class Codes: Y10T 442/2484 : Coating or impregnation is water absorbency-increasing or hydrophilicity-increasing or hydrophilicity-imparting
• CPC Class Codes: Y10T 442/3179 : Woven fabric is characterized by a particular or differential weave other than fabric in which the strand denier or warp/weft pick count is specified
• CPC Class Codes: Y10T 442/3472 : Woven fabric including an additional woven fabric layer
• CPC Class Codes: Y10T 442/3528 : Three or more fabric layers
• CPC Class Codes: Y10T 442/3667 : Composite consisting of at least two woven fabrics bonded by an interposed adhesive layer [but not two woven fabrics bonded together by an impregnation which penetrates through the thickness of at least one of the woven fabric layers]
• CPC Class Codes: Y10T 442/3976 : Including strand which is stated to have specific attributes [e.g., heat or fire resistance, chemical or solvent resistance, high absorption for aqueous composition, water solubility, heat shrinkability, etc.]

Abstract

The invention relates to a substantially laminary manufacture comprising 2 substantially laminary layers in contact, wherein the layers comprise a woven, hydrophilic material.

Claims

1. A carrier for dried blood spot applications comprising a substantially laminar manufacture having a front surface adapted for receiving blood during use comprising at least two substantially laminar layers in contact, wherein the layers each comprise meshes of woven, hydrophilic material, and wherein at least two of the layers are rotated relative to each other by an angle v_nm of 7°

to 83°

, wherein n and m indicate relative layer positions, and wherein upon blood spotting the meshes of at least two layers are filled with blood forming a blood spot with a substantially fixed volume of blood per carrier area, and wherein an area difference, Δ

A, between a first dried blood spot and a second dried blood spot is less than 20%, where the area of the first dried blood spot is the area of a 30 μ

l 80% hematocrit blood sample on the surface after drying 2 hours at 20°

C. in air and the area of the second dried blood spot is the area of a 30 μ

l 20% hematocrit blood sample on the surface after drying 2 hours at 20°

C. in air.

2. The carrier according to claim 1, wherein the area difference, Δ

A, between a first dried blood spot and a second dried blood spot is less than 10%.

3. The carrier according to claim 1, wherein the at least two layers each comprise material with a mesh opening between 11 μ

m and 800 μ

m, a layer thickness between 38 μ

m and 520 μ

m, an open area between 1% and 65%, a mesh count warp between 270 n/cm and 9 n/cm, a mesh count weft of between 206 n/cm and 9 n/cm, a wire diameter warp and a wire diameter between 24 μ

m and 480 μ

m.

4. The carrier according to claim 1, wherein the at least two layers each comprise material with a mesh opening between 20 μ

m and 200 μ

m, a layer thickness between 38 μ

m and 200 μ

m, an open area between 30% and 50%, a mesh count warp between 100 n/cm and 200 n/cm, a mesh count weft of between 100 n/cm and 200 n/cm, a wire diameter warp and a wire diameter between 24 μ

m and 50 μ

m.

5. The carrier according to claim 1, wherein the at least two layers each comprise material with a mesh opening of about 40 μ

m, a layer thickness of about 38 μ

m, an open area between 40%, a mesh count warp between 158 n/cm, a mesh count weft of between 158 n/cm, a wire diameter warp and a wire diameter between 24 μ

m.

6. The carrier according to claim 1, wherein the at least two layers each consist of the same material.

7. The carrier according to claim 1, the substantially laminar manufacture comprises 2 to 18 layers of the material.

8. The carrier according to claim 1, the substantially laminar manufacture comprises 4 to 12 layers of the material.

9. The carrier according to claim 1, wherein the at least two layers are kept in contact by laser welding, ultrasonic welding, punctual glue, laminar glue, or by using a rigid framework.

10. The carrier according to claim 1, further comprising a rigid, laminar sheet or framework in contact with one of the at least two layers.

11. The carrier according to claim 10, wherein the sheet comprises one or more holes.

12. The carrier according to claim 10, wherein the carrier comprises two or more of the manufactures and wherein the sheet is in contact with the two or more manufactures, wherein all of the manufactures are situated behind the holes.

13. The carrier according to claim 1, wherein a first of the at least two substantially laminar layers is rotated by an angle, v₁₂, relative to a second of the at least two substantially laminar layers, and the angle, v₁₂, is 7°

to 83°

.

14. The carrier according to claim 13, wherein the angle, v₁₂, is 10°

to 80°

.

15. The carrier according to claim 13, comprising a third substantially laminar layer connected to the second substantially laminar layer and the third substantially laminar layer is rotated by an angle, v₂₃, relative to the second substantially laminar layer, and the angle, v₂₃, is substantially the same magnitude in the opposite direction of the angle v₁₂ so that the angle, v₁₃, between the first substantially laminar layer and the third substantially laminar layer is about zero.

16. The carrier according to claim 13, comprising a third substantially laminar layer connected to the second substantially laminar layer and the third substantially laminar layer is rotated by an angle, v₂₃, relative to the second substantially laminar layer, whereby the angle, v₁₃, between the first substantially laminar layer and the third substantially laminar layer, as well as the angle v₂₃ are 7°

to 83°

.

17. The carrier according to claim 16, wherein the angles v₁₃and v₂₃ are 10°

to 80°

.

18. The carrier according to claim 1, the substantially laminar manufacture having a back surface facing away from the front surface, wherein the back surface is impermeable for water.

19. The carrier according to claim 1, the substantially laminar manufacture having a back surface facing away from the front surface, and the substantially laminar manufacture comprising at least three substantially laminar layers, wherein substantially laminar layers forming the front surface and/or the back surface have a lower mesh opening than at least one substantially laminar layer arranged between the substantially laminar layers forming the front surface and the back surface.