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Diketopiperazine microparticles with defined specific surface areas

  • US 9,630,930 B2
  • Filed: 04/11/2014
  • Issued: 04/25/2017
  • Est. Priority Date: 06/12/2009
  • Status: Active Grant
First Claim
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1. A method for forming diketopiperazine microparticles comprising:

  • a) dissolving a diketopiperazine in a water-based solution;

    b) adding an acid solution to the water-based solution to precipitate the diketopiperazine microparticles out of the solution to form a microparticle suspension;

    c) adjusting manufacturing conditions to target production microparticles with a specific surface area (SSA) of 52 m2/g;

    d) and collecting the precipitate after washing with deionized water;

    wherein the precipitate comprises diketopiperazine microparticles having a SSA of 35 m2/g to 67 m2/g.

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