Modified FGF-21 polypeptides comprising an internal deletion and uses thereof
First Claim
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1. A modified FGF-21 polypeptide comprising a polypeptide having at least 96% amino acid sequence identity to the amino acid sequence of SEQ ID NO:
- 202.
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Abstract
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.
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Citations
17 Claims
- 1. A modified FGF-21 polypeptide comprising a polypeptide having at least 96% amino acid sequence identity to the amino acid sequence of SEQ ID NO:
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10. A modified FGF-21 polypeptide comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 202, wherein said modified FGF-21 polypeptide is linked to a half-life extending moiety via the para-acetyl-L-phenylalanine in the modified FGF-21 polypeptide.
- View Dependent Claims (11, 12, 13)
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14. A modified FGF-21 polypeptide comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 202, wherein said modified FGF-21 polypeptide is linked to a half-life extending moiety comprising a poly(ethylene glycol) via the para-acetyl-L-phenylalanine in the modified FGF-21 polypeptide.
- View Dependent Claims (15, 16, 17)
Specification