Degradable thiol-ene polymers
First Claim
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1. A photopolymerization system for producing a thiol-ene hydrogel comprising at least one thiol compound and at least one olefin compound, wherein:
- (a) the at least one thiol compound comprises m number of reactive thiol groups;
(b) the at least one olefin compound comprises n number of reactive ene groups;
(c) each of n and m is an integer of at least 2, provided the sum of n+m is at least 5; and
(d) the at least one thiol compound and the at least one olefin compound are capable of undergoing photopolymerization in the presence of water to form a biocompatible thiol-ene containing hydrogel; and
wherein the at least one thiol compound comprises a polymeric moiety selected from hyaluronic acid and gelatin.
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Abstract
A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.
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Citations
19 Claims
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1. A photopolymerization system for producing a thiol-ene hydrogel comprising at least one thiol compound and at least one olefin compound, wherein:
- (a) the at least one thiol compound comprises m number of reactive thiol groups;
(b) the at least one olefin compound comprises n number of reactive ene groups;
(c) each of n and m is an integer of at least 2, provided the sum of n+m is at least 5; and
(d) the at least one thiol compound and the at least one olefin compound are capable of undergoing photopolymerization in the presence of water to form a biocompatible thiol-ene containing hydrogel; andwherein the at least one thiol compound comprises a polymeric moiety selected from hyaluronic acid and gelatin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- (a) the at least one thiol compound comprises m number of reactive thiol groups;
Specification