System and method for measuring biological fluid biomarkers
First Claim
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1. A cloud-based system for analyzing sweat from a human and transmitting and storing sweat data from the human comprising:
- an apparatus for sensing and analyzing sweat, wherein the apparatus includes an electronic layer comprising at least one electrochemical sensor, a microcontroller, and a transceiver antenna coil;
at least one remote transceiver device; and
at least one remote computer server;
wherein the apparatus analyzes at least one sweat biomarker, calculates at least one output datum of the at least one sweat biomarker using at least one algorithm, and transmits the at least one output datum to the at least one remote transceiver device;
wherein the at least one algorithm calculates the at least one output datum using an estimated body surface area of a human and input data, wherein the input data includes at least a height and a weight of the human, and wherein the height and the weight of the human are used to estimate the estimated body surface area of the human;
wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server for storage in a cloud database and/or processing;
wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication; and
wherein the apparatus is flexible and further includes;
a macrofluidic, double-sided adhesive layer;
a microfluidic management layer; and
a vapor porous, top protective layer;
wherein the macrofluidic, double-sided adhesive layer is intimately adhered to an exterior layer of human skin;
wherein the microfluidic management layer is positioned between the macrofluidic, double-sided adhesive layer and the electronic layer;
wherein the microfluidic management layer circumferentially surrounds the at least one electrochemical sensor of the electronic layer;
wherein the at least one electrochemical sensor of the electronic layer is facing the exterior layer of human skin;
wherein the electronic layer is intimately adhered to the macrofluidic, double-sided adhesive layer;
wherein the vapor porous, top protective layer is placed on and completely covers the microfluidic management layer and the electronic layer; and
wherein the vapor porous, top protective layer is intimately adhered to the macrofluidic, double-sided adhesive layer.
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Abstract
Systems and methods of analyzing biological fluid biomarkers, calculating biomarker data, transmitting data to a transceiver device, and storing the data and/or analytics in a database and/or on at least one remote computer server.
20 Citations
20 Claims
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1. A cloud-based system for analyzing sweat from a human and transmitting and storing sweat data from the human comprising:
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an apparatus for sensing and analyzing sweat, wherein the apparatus includes an electronic layer comprising at least one electrochemical sensor, a microcontroller, and a transceiver antenna coil; at least one remote transceiver device; and at least one remote computer server; wherein the apparatus analyzes at least one sweat biomarker, calculates at least one output datum of the at least one sweat biomarker using at least one algorithm, and transmits the at least one output datum to the at least one remote transceiver device; wherein the at least one algorithm calculates the at least one output datum using an estimated body surface area of a human and input data, wherein the input data includes at least a height and a weight of the human, and wherein the height and the weight of the human are used to estimate the estimated body surface area of the human; wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server for storage in a cloud database and/or processing; wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication; and wherein the apparatus is flexible and further includes; a macrofluidic, double-sided adhesive layer; a microfluidic management layer; and a vapor porous, top protective layer; wherein the macrofluidic, double-sided adhesive layer is intimately adhered to an exterior layer of human skin; wherein the microfluidic management layer is positioned between the macrofluidic, double-sided adhesive layer and the electronic layer; wherein the microfluidic management layer circumferentially surrounds the at least one electrochemical sensor of the electronic layer; wherein the at least one electrochemical sensor of the electronic layer is facing the exterior layer of human skin; wherein the electronic layer is intimately adhered to the macrofluidic, double-sided adhesive layer; wherein the vapor porous, top protective layer is placed on and completely covers the microfluidic management layer and the electronic layer; and wherein the vapor porous, top protective layer is intimately adhered to the macrofluidic, double-sided adhesive layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A cloud-based method for analyzing sweat from a human and transmitting and storing sweat data from the human, the method comprising:
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providing an apparatus for sensing and analyzing sweat, wherein the apparatus includes an electronic layer comprising at least one electrochemical sensor, a microcontroller, and a transceiver antenna coil;
at least one remote transceiver device;and at least one remote computer server; wherein the at least one remote transceiver device and the apparatus are operable for two-way cross-communication in real-time or near-real-time; the at least one electrochemical sensor sensing at least one biomarker of the sweat, which creates a voltage; the microcontroller converting the at least one biomarker of the sweat into at least one output datum using at least one algorithm, wherein the at least one algorithm calculates the at least one output datum using an estimated body surface area of a human and input data, wherein the input data includes at least a height and a weight of the human, and wherein the height and the weight of the human are used to estimate the estimated body surface area of the human; the at least one remote transceiver device inputting modifying variables into the at least one algorithm via the two-way communication with the apparatus; the transceiver antenna coil transmitting the at least one output datum to the at least one remote transceiver device via the two-way communication with the apparatus; the at least one remote transceiver device sharing or transmitting the at least one datum with the at least one remote computer server for storage in a cloud database and/or processing; and wherein the apparatus is flexible and further includes; a macrofluidic, double-sided adhesive layer; a microfluidic management layer; and a vapor porous, top protective layer; wherein the macrofluidic, double-sided adhesive layer is intimately adhered to an exterior layer of human skin; wherein the microfluidic management layer is positioned between the macrofluidic, double-sided adhesive layer and the electronic layer; wherein the microfluidic management layer circumferentially surrounds the at least one electrochemical sensor of the electronic layer; wherein the at least one electrochemical sensor of the electronic layer is facing the exterior layer of human skin; wherein the electronic layer is intimately adhered to the macrofluidic, double-sided adhesive layer; wherein the vapor porous, top protective layer is placed on and completely covers the microfluidic management layer and the electronic layer; and wherein the vapor porous, top protective layer is intimately adhered to the macrofluidic, double-sided adhesive layer. - View Dependent Claims (16, 17, 18, 19)
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20. A cloud-based system for continuously analyzing sweat from a human in real-time and transmitting and storing sweat data from the human comprising:
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an apparatus for sensing and analyzing sweat, wherein the apparatus includes an electronic layer comprising at least one electrochemical sensor, a microcontroller, and a transceiver antenna coil; at least one remote transceiver device; and at least one remote computer server; wherein the apparatus continuously analyzes at least one sweat biomarker in real-time, calculates at least one output datum of the at least one sweat biomarker using at least one algorithm, and transmits the at least one output datum to the at least one remote transceiver device; wherein the at least one algorithm calculates the at least one output datum using an estimated body surface area of a human and input data, wherein the input data includes at least a height and a weight of the human, a maximum rate of oxygen consumption for the human (VO2 max), and a body mass of the human, and wherein the height and the weight of the human are used to estimate the estimated body surface area of the human; wherein the at least one remote transceiver device transmits the at least one output datum to the at least one remote computer server for storage in a cloud database and/or processing; wherein the apparatus and the at least one remote transceiver device have real-time or near-real-time two-way communication; wherein the electrochemical sensor has at least one reference electrode and at least one active electrode; wherein the at least one active electrode has an ionophore polymer coating; wherein the apparatus is flexible and further includes; a macrofluidic, double-sided adhesive layer; a microfluidic management layer; and a vapor porous, top protective layer; wherein the macrofluidic, double-sided adhesive layer is intimately adhered to an exterior layer of human skin; wherein the microfluidic management layer is positioned between the macrofluidic, double-sided adhesive layer and the electronic layer; wherein the microfluidic management layer circumferentially surrounds the at least one electrochemical sensor of the electronic layer; wherein the at least one electrochemical sensor of the electronic layer is facing the exterior layer of human skin; wherein the electronic layer is intimately adhered to the macrofluidic, double-sided adhesive layer; wherein the vapor porous, top protective layer is placed on and completely covers the microfluidic management layer and the electronic layer; and wherein the vapor porous, top protective layer is intimately adhered to the macrofluidic, double-sided adhesive layer.
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Specification