Apparatus and methods for ocular injection
First Claim
1. A method, comprising:
- inserting a distal end portion of a puncture member of a medical injector into a target tissue to define a delivery passageway within the target tissue and such that a distal end surface of a hub of the medical injector is in contact with a target surface of the target tissue;
exerting a force on an actuation rod of the medical injector when the distal end surface of the hub is in contact with the target surface, the force having a magnitude of less than a threshold value, the force produces movement within the medical injector of both an adjustment member and the puncture member when the distal end portion of the puncture member is disposed within a first region of the target tissue, the puncture member being fixedly coupled to the adjustment member, movement of both the adjustment member and the puncture member within the medical injector being limited when the distal end portion of the puncture member is disposed within a second region of the target tissue; and
conveying, in response to the exerting, a substance from the medicament container into the target tissue via the puncture member when the distal end portion of the puncture member is disposed within the second region of the target tissue.
8 Assignments
0 Petitions
Accused Products
Abstract
An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
305 Citations
30 Claims
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1. A method, comprising:
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inserting a distal end portion of a puncture member of a medical injector into a target tissue to define a delivery passageway within the target tissue and such that a distal end surface of a hub of the medical injector is in contact with a target surface of the target tissue; exerting a force on an actuation rod of the medical injector when the distal end surface of the hub is in contact with the target surface, the force having a magnitude of less than a threshold value, the force produces movement within the medical injector of both an adjustment member and the puncture member when the distal end portion of the puncture member is disposed within a first region of the target tissue, the puncture member being fixedly coupled to the adjustment member, movement of both the adjustment member and the puncture member within the medical injector being limited when the distal end portion of the puncture member is disposed within a second region of the target tissue; and conveying, in response to the exerting, a substance from the medicament container into the target tissue via the puncture member when the distal end portion of the puncture member is disposed within the second region of the target tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. The method of 1, further comprising:
during the exerting the force on the actuation rod, maintaining a force on the medical injector such that the hub forms a substantially fluid-tight seal with the target surface.
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17. A method, comprising:
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inserting a distal end portion of a puncture member of a medical injector into a target tissue to define a delivery passageway within the target tissue; applying a first force to a hub of the medical injector such that a distal end surface of the hub contacts a target surface of the target tissue to fluidically isolate the delivery passageway; and while maintaining the first force, applying a second force to an actuation rod of the medical injector to move the puncture member relative to the hub such that a distal end portion of the puncture member moves from a first region within the target tissue to a second region with the target tissue, a substance from a medicament container within the medical injector being conveyed to the target tissue in response to the distal end portion of the puncture member being disposed in the second region and not the first region, the second force being insufficient to overcome a backpressure of the first region to convey the medicament into the target tissue via the puncture member when the distal end portion of the puncture member is disposed within the first region. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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24. A method, comprising:
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inserting a distal end portion of a puncture member of a medical injector into a first region of a target tissue to define a delivery passageway within the target tissue, the puncture member placing a substance within a medicament container of the medical injector in fluid communication with the first region, an adjustment member being movably disposed within the medical injector and forming a substantially fluid-tight seal with a side wall of medical injector; after the inserting and with the distal end portion of the puncture member disposed in the first region of the target tissue, exerting a force on the adjustment member such that the force in conjunction with the substantially fluid-tight seal produces movement of the distal end portion of the puncture member from the first region to a second region of the target tissue; and conveying, in response to the exerting, a substance from the medicament container into the target tissue via the puncture member when the distal end portion of the puncture member is disposed within the second region of the target tissue. - View Dependent Claims (25, 26, 27, 28, 29)
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30. The method of 24, further comprising:
during the exerting the force on the actuation rod, maintaining a force on the medical injector such that the hub forms a substantially fluid-tight seal with the target surface.
Specification