Systems for reducing pressure in an organ

• US 9,636,254 B2
• Filed: 11/17/2009
• Issued: 05/02/2017
• Est. Priority Date: 06/30/2006
• Status: Active Grant

• Current Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Original Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Inventors: Yu, Dao-Yi, Anderson, Cory, Trip, Roelof, Yang, Ying, Nguyen, Hoang Van, Mantri, Surag, Su, Er-Ning, Cringle, Stephen, McCrea, James, Mufson, Daniel, Tan, Colin
• Primary Examiner(s): Shi, Katherine M
• Assistant Examiner(s): MENDOZA, MICHAEL G
• Application Number:
  US12/620,564
• Publication Number:
  US 20100100104A1
• Time in Patent Office: 2,723 Days
• Field of Search: 606107, 606108, 606153-155, 623 111, 623 612, 128898
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61L 31/045 Gelatin
• CPC Class Codes: A61M 27/008 pre-shaped, for use in the urethral or ureteral tract

Abstract

Methods, system and apparatus for relieving pressure in an organ such as, but not limited to, the eye are disclosed. The method includes implanting a bioabsorbable channel into the selected area of the organ using a delivery apparatus.

Claims

1. A system for deploying an intraocular shunt, the system comprising:

a deployment device and an intraocular shunt carried by the deployment device, the device comprising;

a housing; and

a deployment mechanism at least partially disposed within the housing and comprising a plunger component, a plunger coupled to a distal segment of the plunger component, a plunger arm, a shaft component, a hollow shaft coupled to the shaft component, a shaft arm, and a longitudinal axis, the plunger component comprising a proximal segment and a plunger pin protruding radially from the proximal segment, the plunger arm comprising a plunger hub slot configured to receive a coupling portion of the plunger component for coupling the plunger component to the plunger arm, the shaft component comprising a proximal segment and a shaft pin protruding radially from the shaft component proximal segment, the shaft arm comprising a shaft hub slot configured to receive a coupling portion of the shaft component for coupling the shaft component to the shaft arm;

wherein the shaft is coupled to the deployment mechanism such that the plunger is slidable along the axis within the shaft, wherein the shaft is configured to hold the shunt, and

wherein the deployment mechanism is configured (i) to advance the shunt along the axis within the shaft by pushing the shunt with the plunger, without moving the shaft, to a partially exposed position in which a proximal portion of the shunt is disposed within the shaft and a distal portion of the shunt is disposed beyond a distal end of the shaft, and then, (ii) while a longitudinal position of the shunt is substantially maintained along the axis, relative to the housing, by the plunger, to retract the shaft such that the distal end of the shaft is retracted proximally of the shunt proximal portion.

2. The system according to claim 1, wherein a distal end of the shaft is beveled.

3. The system according to claim 1, wherein the hollow shaft is a needle.

4. The system according to claim 1, wherein the shaft is removable from the deployment mechanism.

5. The system according to claim 1, wherein the deployment mechanism includes a stopper that limits longitudinal movement of the shaft along the axis.

6. The system according to claim 1, wherein the shunt comprises:

a hollow channel defining an inlet configured to receive fluid from an anterior chamber of an eye, and an outlet configured to direct the fluid to a location of low pressure with respect to the anterior chamber;

the hollow channel comprising an outer surface that is expandable.

7. The system according to claim 6, wherein the hollow channel is bioabsorbable.

8. The system according to claim 6, wherein said hollow channel defines a flow path extending from the inlet to the outlet and that remains substantially constant as the outer surface expands.

9. The system according to claim 6, wherein the shunt comprises a cross-linked gelatin.

10. The system according to claim 6, further comprising at least one member on the outer surface that assists in retaining the shunt in the eye.

11. The system according to claim 1, wherein the shunt comprises:

a hollow channel defining a flow path and having an inlet configured to receive fluid from an anterior chamber of an eye and an outlet configured to direct the fluid to a location of low pressure with respect to the anterior chamber, wherein the channel further comprises a variable inner diameter.

12. The system according to claim 11, wherein the inner diameter increases along the length of the channel from the inlet to the outlet.

13. The system according to claim 11, wherein the inner diameter continuously increases along the length of the channel.

14. The system according to claim 11, wherein the inner diameter remains constant along portions of the length of the channel.

15. The system according to claim 11, further comprising at least one member on an outer surface of the channel that assists in retaining the shunt in the eye.

16. The system according to claim 1, wherein the deployment mechanism is further configured such that the shunt is positioned adjacent the distal end of the shaft prior to operation of the deployment mechanism.

17. The system according to claim 1, wherein the shaft is configured to hold the shunt with the shaft distal end extending beyond the shunt distal portion.

18. The system according to claim 1, wherein the shaft and plunger pins constrain movement of the shaft component and the plunger component such that the shaft and the plunger are longitudinally movable along the axis relative to the housing.

19. The system according to claim 1, wherein the shaft and plunger pins constrain radial movement of the shaft component and the plunger component.

20. The system according to claim 19, wherein the shaft and plunger pins are configured to contact an inner surface of the housing to maintain longitudinal alignments of the coupling portions of the shaft component and the plunger component along the axis.

21. The system according to claim 1, further comprising a plunger motor coupled to the plunger arm for longitudinally moving the plunger along the axis and a shaft motor coupled to the shaft arm for longitudinally moving the shaft along the axis.

22. A method for deploying a shunt into an eye, the method comprising:

providing a system for deploying an intraocular shunt, the system comprising;

a deployment device comprising;

a housing;

a deployment mechanism at least partially disposed within the housing and comprising a plunger and a longitudinal axis; and

a hollow shaft coupled to the deployment mechanism such that the plunger is slidably disposed within the shaft along the axis, wherein the shaft is configured to hold an intraocular shunt;

inserting the system into an eye;

advancing the plunger along the axis to move the shunt to a partially exposed position in which a proximal portion of the shunt is disposed within the shaft and a distal portion of the shunt is disposed beyond a distal end of the shaft; and

after advancing the shunt to the exposed position, and while substantially maintaining a longitudinal position of both the plunger and the shunt along the axis, relative to the housing, retracting the distal end of the shaft proximally of the shunt proximal portion to release the shunt from the shaft of the deployment device.

23. The method according to claim 22, wherein the shunt is deployed such that an inlet receives fluid flow from an anterior chamber of the eye and an outlet directs flow to a location of low pressure with respect to the anterior chamber.

24. The method according to claim 23, wherein the location is selected from the group consisting of:

the subconjunctival space, the episcleral vein, the suprachoroidal space, and Schlemm'"'"'s canal.

25. The method according to claim 22, wherein the inserting comprises inserting the system through the cornea.

26. The method according to claim 22, wherein the inserting comprises:

inserting into the cornea or the limbus of the eye a hollow shaft that is configured to hold the shunt; and

advancing the shaft transocularly across the anterior chamber of the eye until the subconjunctival space is reached.

27. The method according to claim 26, wherein the inserting is conducted without penetrating the conjunctiva.

28. The method according to claim 22, wherein the shunt is positioned adjacent the distal end of the shaft during the inserting.

29. The method according to claim 22, wherein the shaft distal end extends beyond the shunt distal portion during the inserting.

30. The method according to claim 22, wherein movement of the plunger and the shaft is driven by a slot-and-pin mechanism.

31. The method according to claim 30, wherein the slot-and-pin mechanism is configured with the shaft and the plunger each comprising coupling portions at respective proximal sections thereof, the plunger coupling portion comprising a pin extending radially therefrom and constraining movement of the plunger, the shaft coupling portion comprising a pin extending radially therefrom and constraining movement of the shaft.

32. The method according to claim 31, wherein the pins constrain movement of the shaft and the plunger such that the shaft and the plunger are longitudinally movable along the axis relative to the housing.

33. The method according to claim 31, wherein the pins constrain radial movement of the shaft and the plunger.

34. The method according to claim 33, wherein the pins are configured to contact an inner surface of the housing to maintain longitudinal alignments of the coupling portions of the shaft and the plunger along the axis.

35. The method according to claim 31, further comprising a plunger arm and a shaft arm, the plunger arm comprising a plunger hub slot configured to receive the plunger coupling portion for coupling the plunger to the plunger arm, the shaft arm comprising a shaft hub slot configured to receive the shaft coupling portion for coupling the shaft to the shaft arm.

36. The method according to claim 35, further comprising a plunger motor coupled to the plunger arm for longitudinally moving the plunger along the axis and a shaft motor coupled to the shaft arm for axially moving the shaft along the axis.

37. The method according to claim 22, wherein the advancing the plunger comprises driving the plunger movement by a motor.

38. The method according to claim 22, wherein the retracting the shaft comprises driving the shaft movement by a motor.

39. The method according to claim 22, wherein the advancing the plunger comprises manually driving the plunger movement.

40. The method according to claim 22, wherein the retracting the shaft comprises manually driving the shaft movement.