×

Tamper resistant dosage form comprising an anionic polymer

  • US 9,636,303 B2
  • Filed: 09/01/2011
  • Issued: 05/02/2017
  • Est. Priority Date: 09/02/2010
  • Status: Expired due to Fees
First Claim
Patent Images

1. A pharmaceutical dosage form comprising:

  • a pharmacologically active ingredient (A) selected from the group consisting of opioids;

    a physiologically acceptable polymer (B) selected from the group consisting of;

    (i) optionally cross-linked homopolymers of acrylic acid;

    (ii) optionally crosslinked copolymers of acrylic acid and C10-30-alkyl acrylates; and

    (iii) interpolymers of (a) or (b) each taken with (c), wherein (a) is an optionally crosslinked homopolymer of acrylic acid, (b) is an optionally crosslinked copolymer of acrylic acid and C10-30-alkyl acrylate, and (c) is a block copolymer of polyethylene glycol and a long chain alkyl acid;

    a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form;

    wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the polymer (B) and the polyalkylene oxide (C);

    wherein the dosage form is thermoformed; and

    wherein the dosage form exhibits a breaking strength of at least 500 N.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×