Method for treating skin cancer

• US 9,636,320 B2
• Filed: 09/28/2015
• Issued: 05/02/2017
• Est. Priority Date: 07/26/2012
• Status: Active Grant

• Current Assignee: The William M. Yarbrough Foundation
• Original Assignee: The William M. Yarbrough Foundation
• Inventors: Silver, Michael E.
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US14/867,585
• Publication Number:
  US 20160015674A1
• Time in Patent Office: 582 Days
• Field of Search: 514629, 514638
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/26 Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07C 331/20 of a saturated carbon skeleton

Abstract

A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

Claims

1. A method for treating skin cancer, comprising the step(s) of:

applying a lysine derivative to an area affected by skin cancer, wherein the lysine derivative comprises an α

-nitrogen and a ε

-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least approximately 8 carbon atoms is associated with the α

-nitrogen, and further wherein at least one isothiocyanate functional group is associated with the ε

-nitrogen.

2. The method for treating skin cancer, according to claim 1, wherein the skin cancer is selected from one of the groups comprising basal cell carcinoma, squamous cell carcinoma, melanoma, and merkel cell carcinoma.

3. A method for treating skin cancer, comprising the step(s) of:

applying a lysine derivative to an area affected by skin cancer, wherein the lysine derivative includes an α

-nitrogen and a ε

-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least 8 carbon atoms is associated with the α

-nitrogen, and further wherein at least one isothiocyanate functional group is associated with the ε

-nitrogen.

4. The method for treating skin cancer, according to claim 3, wherein the skin cancer is selected from one of the groups comprising basal cell carcinoma, squamous cell carcinoma, melanoma, and merkel cell carcinoma.

5. A method for treating skin cancer, comprising the step(s) of:

applying a lysine derivative to an area affected by skin cancer, wherein the lysine derivative comprises an α

-nitrogen and a ε

-nitrogen, and wherein an alkyl substituent comprising at least 8 carbon atoms is associated with the α

-nitrogen, and further wherein at least one isothiocyanate functional group is associated with the ε

-nitrogen.

6. The method for treating skin cancer, according to claim 5, wherein the skin cancer is selected from one of the groups comprising basal cell carcinoma, squamous cell carcinoma, melanoma, and merkel cell carcinoma.