Adaptive cycling for respiratory treatment apparatus

• US 9,636,474 B2
• Filed: 08/25/2011
• Issued: 05/02/2017
• Est. Priority Date: 08/27/2010
• Status: Active Grant

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Mulqueeny, Qestra Camille, Tassaux, Didier
• Primary Examiner(s): Ho, Tan-Uyen (Jackie) T
• Assistant Examiner(s): Boecker, Joseph D
• Application Number:
  US13/819,037
• Publication Number:
  US 20130152934A1
• Time in Patent Office: 2,077 Days
• Field of Search: None
• CPC Class Codes: A61M 16/0066 Blowers or centrifugal pumps
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/46 Resistance or compliance of the lungs
• CPC Class Codes: A61M 2230/60 Muscle strain, i.e. measured on the user

Abstract

A controller or processor (s) implements detection of respiratory related conditions that may serve as control logic to synchronize pressure treatment delivery with a patient'"'"'s respiratory cycle. Based on data derived from sensor signals associated with the respiratory treatment, a monitoring device, detector or respiratory treatment apparatus may evaluate flow measures from a flow sensor and distinguish flow attributable to the respiratory treatment apparatus and flow attributable to patient respiratory muscles. The determination may serve as a basis of synchronization criteria that controls pressure levels from a pressure treatment apparatus, such as by evaluating the determined patient generated flow or a relationship between total flow and apparatus flow. In some embodiments, data for the cycling conditions is determined in preliminary treatment cycles during which synchronized pressure changes are controlled according to other cycling criteria. The new cycling conditions are then automatically initiated for control of synchronization in subsequent cycles.

Claims

1. An automated processing method for adapting cycling of a respiratory treatment apparatus that controls a delivery of a synchronized respiratory treatment to a patient, the method comprising:

controlling generation of inspiratory pressure and expiratory pressure over a first plurality of cycles with a processor, wherein timing of delivery of the expiratory pressure for the first plurality of cycles is based on first cycling criteria; and

controlling generation of inspiratory pressure and expiratory pressure over a second plurality of cycles subsequent to the first plurality of cycles with the processor, wherein timing of delivery of the expiratory pressure for the second plurality of cycles is based on second cycling criteria, the second cycling criteria being different from the first cycling criteria and initiated for operation subsequent to the first plurality of cycles,

wherein the second cycling criteria are determined during the first plurality of cycles, and

wherein each of the first and second cycling criteria controls synchronization of the respiratory treatment with the patient'"'"'s breathing cycle.

2. The method of claim 1 wherein the second cycling criteria comprise a function of a first inspiratory flow measure and a second inspiratory flow measure, the second inspiratory flow measure attributable to the respiratory treatment apparatus,

in which each of the first inspiratory flow measure and the second inspiratory flow measure is from a sensor.

3. The method of claim 2 wherein the first cycling criteria comprise comparing an instantaneous flow measure to a threshold proportion of a peak flow.

4. The method of claim 1 wherein the first plurality of cycles comprises a learning period that is configured for determining and storing values for control of treatment in a plurality of subsequent treatment sessions.

5. The method of claim 1 wherein the first plurality of cycles comprises a learning period that is initiated in a current treatment session.

6. The method of claim 1 wherein the second cycling criteria comprise an inspiratory time constant.

7. The method of claim 6 wherein the inspiratory time constant is a function of a determined slope of an expiratory portion of a measured flow from the first plurality of cycles.

8. The method of claim 7 wherein the inspiratory time constant is a mean of a plurality of determined slopes of expiratory portions of the measured flow from the first plurality of cycles.

9. The method of claim 6 wherein the inspiratory time constant is from a measured flow from the first plurality of cycles and is a measured time for a proportion of a tidal volume to be delivered to the patient in a cycle of the first plurality of cycles.

10. The method of claim 9 wherein the inspiratory time constant is a mean of measured times for a proportion of a tidal volume to be delivered to the patient in the first plurality of cycles.

11. The method of claim 6 wherein a determination of the inspiratory time constant comprises a multiple linear regression process to fit pressure, flow and volume data for determining a measure of resistance and compliance.

12. The method of claim 2 wherein the function of the first inspiratory flow measure and the second inspiratory flow measure comprises an equality of the first inspiratory flow measure and the second inspiratory flow measure.

13. The method of claim 2 wherein the function of the first inspiratory flow measure and the second inspiratory flow measure comprises a calculated difference of the first inspiratory flow measure and the second inspiratory flow measure.

14. The method of claim 2 wherein the second inspiratory flow measure is a function of a determined flow peak, a calculated respiratory resistance and a pressure treatment setting.

15. A respiratory treatment apparatus for cycling synchronized respiratory pressure treatment to a patient, the apparatus comprising:

a patient interface to direct a breathable gas;

a flow generator coupled with the patient interface to generate the breathable gas in inspiratory and expiratory pressure cycles through the patient interface;

a flow sensor to provide a signal indicative of flow through the patient interface;

a processor, coupled with the flow generator and the flow sensor, the processor configured to control;

generation of inspiratory pressure and expiratory pressure over a first plurality of cycles, wherein timing of delivery of the expiratory pressure for the first plurality of cycles is based on first cycling criteria; and

generation of inspiratory pressure and expiratory pressure over a second plurality of cycles subsequent to the first plurality of cycles, wherein timing of delivery of the expiratory pressure for the second plurality of cycles is based on second cycling criteria, the second cycling criteria being different from the first cycling criteria and initiated for operation subsequent to the first plurality of cycles,

wherein the second cycling criteria are determined during the first plurality of cycles, and

wherein each of the first and second cycling criteria controls synchronization of the respiratory treatment with the patient'"'"'s breathing cycle.

16. The apparatus of claim 15 wherein the second cycling criteria comprise a function of a first inspiratory flow measure from the flow sensor and a second inspiratory flow measure from a second sensor attributable to the respiratory treatment apparatus.

17. The apparatus of claim 16 wherein the first cycling criteria comprise comparing an instantaneous flow measure to a threshold proportion of a peak flow.

18. The apparatus of claim 15 wherein the first plurality of cycles comprises a learning period that is configured for determining and storing values for control of treatment in a plurality of subsequent treatment sessions.

19. The apparatus of claim 15 wherein the first plurality of cycles comprises a learning period that is initiated in each treatment session.

20. The apparatus of claim 15 wherein the second cycling criteria comprise an inspiratory time constant.

21. The apparatus of claim 20 wherein the inspiratory time constant is a function of a determined slope of an expiratory portion of a measured flow from the first plurality of cycles.

22. The apparatus of claim 21 wherein the inspiratory time constant is a mean of a plurality of determined slopes of expiratory portions of the measured flow from the first plurality of cycles.

23. The apparatus of claim 20 wherein the inspiratory time constant is from a measured flow from the first plurality of cycles and is a measured time for a proportion of a tidal volume to be delivered to the patient in a cycle of the first plurality of cycles.

24. The apparatus of claim 23 wherein the inspiratory time constant is a mean of measured times for a proportion of a tidal volume to be delivered to the patient in the first plurality of cycles.

25. The apparatus of claim 20 wherein the inspiratory time constant is calculated as a function of resistance and compliance values determined by a multiple linear regression process with pressure, flow and volume data.

26. The apparatus of claim 16 wherein the function of the first inspiratory flow measure and the second inspiratory flow measure comprises an equality of the first inspiratory flow measure and the second inspiratory flow measure.

27. The apparatus of claim 16 wherein the function of the first inspiratory flow measure and the second inspiratory flow measure comprises a calculated difference of the first inspiratory flow measure and the second inspiratory flow measure.

28. The apparatus of claim 16 wherein the second inspiratory flow measure is a function of a determined flow peak, a calculated respiratory resistance and a pressure treatment setting.