Cardiac pacing sensing and control

• US 9,636,505 B2
• Filed: 11/24/2015
• Issued: 05/02/2017
• Est. Priority Date: 11/24/2014
• Status: Active Grant

• Current Assignee: Atacor Medical Inc.
• Original Assignee: Atacor Medical Inc.
• Inventors: Sanghera, Rick, Marcovecchio, Alan, McGeehan, Sean
• Primary Examiner(s): Manuel, George
• Application Number:
  US14/951,277
• Publication Number:
  US 20160144192A1
• Time in Patent Office: 525 Days
• CPC Class Codes: A61N 1/0504 Subcutaneous electrodes
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/059 Anchoring means
• CPC Class Codes: A61N 1/3629 in combination with non-electric therapy
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3752 Details of casing-lead connections

Abstract

A cardiac pacing system having a pulse generator for generating therapeutic electric pulses, a lead electrically coupled with the pulse generator having an electrode, a first sensor configured to monitor a physiological characteristic of a patient, a second sensor configured to monitor a second physiological characteristic of a patient and a controller. The controller can determine a pacing vector based on variables including a signal received from the second sensor, and cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector. The controller can also modify pacing characteristics based on variables including a signal received from the second sensor.

Claims

1. A cardiac pacing system comprising:

a pulse generator including a housing, the pulse generator configured to generate therapeutic electric pulses to a heart of a patient;

at least one lead, wherein a proximal end of the at least one lead is configured to electrically couple with the pulse generator and a distal end of the at least one lead is configured to be implanted within a mediastinum of the patient in a location not in or on the heart of the patient, the at least one lead including an electrode;

a first sensor configured to monitor a physiological characteristic of the patient;

a second sensor configured to monitor a second physiological characteristic of the patient; and

a controller configured to;

determine a pacing vector based on variables including a signal received from the second sensor; and

cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector.

2. The cardiac pacing system of claim 1 wherein the first sensor is an electrode configured to sense heart rate and wherein the controller is further configured to determine a pacing vector based on variables including a signal received from the first sensor.

3. The cardiac pacing system of claim 2 wherein the housing includes at least one housing electrode configured to act as a sensor or as an electrode and the controller is configured to determine a pacing vector based on at least a signal transmitted from the housing electrode.

4. The cardiac pacing system of claim 2 wherein the controller is configured to cause the pulse generator to deliver the therapeutic electrical pulses from more than one electrode.

5. The cardiac pacing system of claim 4 wherein the therapeutic electrical pulses are delivered in a manner where more than one electrode acts as a cathode and more than one electrode acts as an anode.

6. The cardiac pacing system of claim 2 wherein the second sensor is an accelerometer.

7. The cardiac pacing system of claim 2 wherein the second sensor is an acoustic sensor.

8. The cardiac pacing system of claim 2 wherein the variables include a sensed amount of skeletal muscle stimulation during pacing.

9. The cardiac pacing system of claim 2 wherein the variables include a sensed posture of the patient.

10. The cardiac pacing system of claim 2 wherein the variables include a sensed heart rate of the patient.

11. The cardiac pacing system of claim 2 wherein the variables include the energy required by potential pacing vectors.

12. The cardiac pacing system of claim 2 wherein the variables include the distance between an electrode utilized for delivery of the therapeutic electrical pulses and a sensor.

13. The cardiac pacing system of claim 2 wherein the controller is further configured to utilize a weighted scoring method in determining the pacing vector.

14. The cardiac pacing system of claim 2 wherein the controller is further configured for a vector selection assessment.

15. The cardiac pacing system of claim 14 wherein a, patient perception of discomfort is considered in the vector selection assessment.

16. The cardiac pacing system of claim 14 wherein the controller is further configured to determine the pacing vector based on results of the vector selection assessment.

17. A cardiac pacing system comprising:

a pulse generator configured to generate therapeutic electric pulses to a heart of a patient;

at least one lead, wherein a proximal end of the at least one lead is configured to electrically couple with the pulse generator and a distal end of the at least one lead is configured to be implanted within a mediastinum of the patient in a location not in or on the heart of the patient, the at least one lead including an electrode;

a first sensor configured to monitor a characteristic of the patient;

a second sensor configured to monitor a second characteristic of the patient and

a controller configured to;

modify pacing characteristics based on variables including a signal received from the second sensor, and

cause the pulse generator to deliver the therapeutic electrical pulses according to the determined modified pacing characteristics.

18. The cardiac pacing system of claim 17 wherein the pacing characteristics are selected from the group consisting of pacing vector, pulse energy and pulse width.

19. The cardiac pacing system of claim 17 wherein the first sensor is an electrode configured to sense heart rate and wherein the controller is further configured to modify pacing characteristics based on variables including a signal received from the first sensor.

20. The cardiac pacing system of claim 19 wherein the second sensor is a multi-axis accelerometer configured to monitor a posture of the patient.

21. The cardiac pacing system of claim 20 wherein the controller being configured to modify pacing characteristics includes modifying the pacing characteristics in a manner proportional to a change in posture.

22. The cardiac pacing system of claim 19 wherein the controller is further configured to operate with a programmer to develop empirical data to assist in modifying pacing characteristics based on posture.

23. The cardiac pacing system of claim 22 wherein the empirical data comprises pacing characteristics required for different postures.

24. The cardiac pacing system of claim 19 wherein the second sensor is an accelerometer configured to monitor skeletal muscle deflection.

25. The cardiac pacing system of claim 24 wherein the controller being configured to modify pacing characteristics includes comparing the signal from the accelerometer during pacing to the signal from the accelerometer during intrinsic heartbeat activity.

26. The cardiac pacing system of claim 24 wherein the controller is further configured to operate with a programmer to develop empirical data to assist in modifying pacing characteristics based on skeletal muscle deflection.

27. The cardiac pacing system of claim 26 wherein the empirical data comprises pacing characteristics correlated with patient discomfort.

28. The cardiac pacing system of claim 19 wherein the second sensor is configured to determine R-wave intervals.

29. The cardiac pacing system of claim 28 wherein the controller is further configured to determine an interval threshold based on sensed R-wave intervals and wherein the controller being configured to modify pacing characteristics comprises providing for a pacing pulse when the interval threshold is reached without detection of an intrinsic R-wave.

30. The cardiac pacing system of claim 19 wherein the controller being configured to modify pacing characteristics comprises limiting the pacing characteristics to a ventricular pacing rate not exceeding a maximum ventricular tracking rate threshold.

31. The cardiac pacing system of claim 19 wherein the controller being configured to modify pacing characteristics comprises switching to a non-tracking mode in response to the sensing of a prolonged, highly variable or high rate atrial arrhythmia.