Nanoscale apertures having islands of functionality
First Claim
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1. An array of nanoscale apertures comprising:
- a transparent substrate having a cladding layer deposited on its surface, the cladding layer having a plurality of nanoscale apertures extending therethrough;
each nanoscale aperture having walls and a base and each nanoscale aperture having an island of island material on the base of the aperture, wherein the island does not contact the walls of the nanoscale aperture, and wherein the island material is a metallic, dielectric, or semiconductor material.
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Abstract
Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided. Arrays of confined regions are produced wherein each confined region comprises a single island within the confined region. The island can be selectively functionalized with a coupling agent to couple a single molecule of interest within the confined region.
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16 Claims
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1. An array of nanoscale apertures comprising:
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a transparent substrate having a cladding layer deposited on its surface, the cladding layer having a plurality of nanoscale apertures extending therethrough; each nanoscale aperture having walls and a base and each nanoscale aperture having an island of island material on the base of the aperture, wherein the island does not contact the walls of the nanoscale aperture, and wherein the island material is a metallic, dielectric, or semiconductor material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification