Highly selective chemical and biological sensors

• US 9,638,653 B2
• Filed: 05/12/2015
• Issued: 05/02/2017
• Est. Priority Date: 11/09/2010
• Status: Active Grant

• Current Assignee: GE Infrastructure Technology, LLC (GE Vernova, Inc.)
• Original Assignee: General Electric Company
• Inventors: Potyrailo, Radislav Alexandrovich, Surman, Cheryl Margaret, Burns, Andrew Arthur Paul, Nagraj, Nandini
• Primary Examiner(s): Le, John H
• Application Number:
  US14/710,299
• Publication Number:
  US 20160223484A1
• Time in Patent Office: 721 Days
• Field of Search: 702 19, 702 23, 702 25, 702 30, 324 711, 324602, 324633, 324652, 324655, 73 3105, 73 6453, 310360, 340 10, 340 41
• CPC Class Codes: G01N 27/02 by investigating impedance
• CPC Class Codes: G01N 27/026 Dielectric impedance spectroscopy electrochemical impedance spectroscopy for measuring corrosion G01N17/02
• CPC Class Codes: G01N 33/483 Physical analysis of biological material
• CPC Class Codes: G01N 33/48792 Data management, e.g. communication with processing unit for in vivo diagnostics A61B5/0002; transmission systems for measured values G08C

Abstract

Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture.

Claims

1. A sensor, comprising:

a single transducer having transducer electrodes, wherein the single transducer has a multivariate output to independently detect effects of different environmental parameters on the sensor; and

a sensing material disposed on the single transducer and having a preserved magnitude of response to an analyte over a broad concentration range of an interferent, wherein the sensing material is configured to have a preserved magnitude of response for at least six different analyte fluids from an analyzed fluid mixture, and wherein the sensor is configured to sense a first fluid in the analyzed fluid mixture in the presence of a second fluid in the analyzed fluid mixture, and wherein a concentration of the second fluid is at least 1 million times greater than a concentration of the first fluid.

2. The sensor of claim 1, wherein the sensing material has multiple response mechanisms to analytes and interferents.

3. The sensor of claim 2, wherein the response mechanisms of the sensing material are related to the changes of dielectric constant, resistance, and swelling of the sensing material, and wherein the changes are not fully correlated with each other and produce different patterns upon exposure to individual fluids and their mixtures.

4. The sensor of claim 1, wherein the single transducer comprises an inductor-capacitor-resistor (LCR) transducer.

5. The sensor of claim 4, wherein the LCR transducer comprises an RFID transducer with an integrated circuit chip.

6. The sensor of claim 4, wherein the sensor has multiple components of LCR response from the LCR transducer, and wherein the multiple components of LCR response originate from one or more factors affecting the LCR transducer.

7. The sensor of claim 6, wherein the one or more factors comprise resistance and capacitance of the sensing material, resistance and capacitance between the transducer electrodes and the sensing material, and resistance and capacitance between a transducer substrate and the sensing material.

8. A sensor, comprising:

a single transducer having transducer electrodes, wherein the single transducer has a multivariate output to independently detect effects of different environmental parameters on the sensor; and

a composite sensing material disposed on the single transducer and having a preserved magnitude of response to an analyte over a broad concentration range of an interferent, wherein the composite sensing material comprises a plurality of individual sensing materials that are homogeneously or inhomogeneously mixed or locally patterned over specific portions of the single transducer such that each of the plurality of individual sensing materials is arranged to respond to analytes by predominantly different response mechanisms, and wherein the composite sensing material is phase-separate due to hydrophylic/hydrophobic interactions or mutual immiscibility, formed as sectors of individual materials deposited adjacent to each other onto a single sensor, or formed as layers of individual materials deposited on top of each other onto a single sensor.

9. The sensor of claim 8, wherein the single transducer comprises an inductor-capacitor-resistor (LCR) transducer.

10. The sensor of claim 8, wherein the sensor is configured to sense the analyte when a concentration of the interferent is at least ten times greater than a concentration of the analyte.

11. The sensor of claim 10, wherein the interferent comprises water vapor.

12. A sensor, comprising:

a single transducer having transducer electrodes, wherein the single transducer has a multivariate output to independently detect effects of different environmental parameters on the sensor;

a sensing material disposed on the single transducer and having a preserved magnitude of response to an analyte over a broad concentration range of an interferent; and

an integrated circuit device comprising a diode rectifier, a network analyzer, a first processor, and a second processor;

wherein the integrated circuit device is configured to control selectivity of the sensor response;

wherein the diode rectifier is configured to power the sensor to at least two power levels to affect at least one of the dipole moment, the dielectric constant, and the temperature of the sensing material;

wherein the network analyzer is configured to collect spectral parameters of the sensor response at the at least two power levels;

wherein the first processor is configured to perform multivariate analysis of the spectral parameters from combined impedance spectral profiles of the sensor at the different power levels; and

wherein the first processor or the second processor are configured to calculate values of environmental parameters to which the sensor is exposed from data produced by performing the multivariate analysis.

13. The sensor of claim 12, wherein the first processor is configured to perform multivariate analysis of the spectral parameters such that differences in the spectral profiles at each of the at least two different power levels are pronounced in different values of Fp, F1, F2, Fz, Zp, Z1, Z2, and calculated values of C and R.

14. The sensor of claim 12, wherein the at least two power levels are in a range from −

50 dBm to +40 dBm.

15. The sensor of claim 12, wherein the first processor or the second processor is configured to calculate a concentration of the analyte in the presence of the interferent.

16. The sensor of claim 12, wherein the multivariate analysis comprises principal components analysis, canonical correlation analysis, regression analysis, nonlinear regression analysis, discriminate function analysis, multidimensional scaling, linear discriminate analysis, logistic regression, neural network analysis, or any combination thereof.

17. The sensor of claim 12, wherein a first power level of the at least two power levels is in a range of approximately −

40 dBm to −

1 dBm, and wherein a second power level of the at least two power levels is in a range of approximately 0 dBm to 40 dBm.

18. The sensor of claim 17, wherein the diode rectifier is configured to power the sensor to the at least two power levels on a time scale which is at least 5 times faster than dynamic changes in measured environmental parameters.