System and method for a biosensor monitoring and tracking band

• US 9,642,538 B2
• Filed: 09/25/2016
• Issued: 05/09/2017
• Est. Priority Date: 07/19/2015
• Status: Active Grant

• Current Assignee: Trilinear Bioventures LLC
• Original Assignee: Sanmina-SCI Corporation
• Inventors: Newberry, Robert Steven
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US15/275,444
• Publication Number:
  US 20170014035A1
• Time in Patent Office: 226 Days
• Field of Search: None
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/117 Identification of persons methods or arrangements for recognising patterns, e.g. fingerprints, G06F18/00, G06V40/00; identification of persons by analysing their voice or speech G10L17/00
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/6823 Trunk, e.g., chest, back, abdomen, hip
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/6825 Hand
• CPC Class Codes: A61B 5/6826 : Finger
• CPC Class Codes: A61B 90/96 : using barcodes
• CPC Class Codes: A61B 90/98 : using electromagnetic means, e.g. transponders
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: G16Z 99/00 : Subject matter not provided for in other main groups of this subclass

Abstract

A health care band operably attaches a biosensor to a patient. The biosensor includes one or more sensors for collecting vitals of a patient and a wireless transmitter that is configured to communicate with an EMR network that stores and maintains an EMR of the patient. The biosensor stores a unique identification associated with the patient'"'"'s EMR such that vitals measured by the biosensor may be transmitted with the patient'"'"'s unique identification for storage in the patient'"'"'s EMR. The sensors in the biosensor may include a thermometer, motion detector/accelerometer, pulse detector and oximeter, etc. In an embodiment, one of the sensors in the biosensor includes a photoplethysmography (PPG) based sensor that may be configured to continuously or periodically measure a patient'"'"'s vitals, such as heart rate, pulse, blood oxygen levels, blood glucose or insulin levels, or other blood analytics in vitro.

Claims

1. A health care monitoring system, comprising:

a health care band configured for attachment to a patient;

a biosensor attached to the health care band, comprising;

a memory configured to store a unique patient identification;

a temperature sensor configured to obtain a temperature of the patient;

a PPG circuit configured to emit light at a plurality of wavelengths directed at skin of the patient and obtain a plurality of spectral responses at each of the plurality of wavelengths of light reflected from the skin, including;

obtaining a first spectral response around a first wavelength responsive to nitric oxide (NO) levels in arterial blood flow;

obtaining a second spectral response around a second wavelength with a low absorption coefficient for nitric oxide (NO) in arterial blood flow;

a processing circuit configured to;

obtain an indicator of a concentration level of NO of the patient using the spectral responses at the plurality of wavelengths by;

isolating a systolic point and a diastolic point in the first spectral response and obtain a value L<sub>λ

1</sub> using a ratio of the systolic point and the diastolic point in the first spectral response;

isolating a systolic point and a diastolic point in the second spectral response and obtain a value L<sub>λ

2</sub> using a ratio of the systolic point and diastolic point in the second spectral response;

obtaining a value R<sub>λ

1,λ

2</sub> from a ratio of the value L<sub>λ

1</sub> and the value L<sub>λ

2</sub>, wherein the value R<sub>λ

1,λ

2</sub> is the indicator of the concentration level of NO of the patient;

determine patient vitals using additional spectral responses, wherein the patient vitals include oxygen saturation levels; and

obtain concentration levels of one or more additional substances in arterial blood flow using the spectral responses, including;

obtaining a blood glucose concentration level of the patient from the indicator of the concentration level of NO of the value R<sub>λ

1,λ

2</sub> and a calibration table, wherein the calibration table correlates a plurality of the blood glucose concentration levels with a plurality of the values R<sub>λ

1,λ

2</sub>; and

a wireless transceiver configured to transmit the temperature, oxygen saturation levels, the blood glucose concentration level and the unique patient identification.

2. The health care monitoring system of claim 1, wherein the PPG circuit is further configured to:

obtain the value L<sub>λ

1</sub> using a first spectral response around a first wavelength responsive to a liver enzyme P450 in arterial blood flow; and

obtain the value L₂ using a second spectral response around a second wavelength with a low absorption coefficient for the liver enzyme P450 in arterial blood flow; and

obtain a liver enzyme value R<sub>λ

1,λ

2</sub> from the ratio of the value L<sub>λ

1</sub> from the first spectral response and the value L<sub>λ

2</sub> from the second spectral response, wherein the liver enzyme value R<sub>λ

1,λ

2</sub> is an indicator of the concentration level of the liver enzyme P450 in arterial blood flow.

3. The health care monitoring system of claim 2, wherein the processing circuit is configured to obtain concentration levels of one or more additional substances in arterial blood flow using the spectral responses by:

obtaining a concentration level of blood alcohol in the arterial blood flow using the liver enzyme value R<sub>λ

1,λ

2</sub> and a second calibration table, wherein the second calibration table correlates a plurality of blood alcohol concentration levels with a plurality of the liver enzyme values R<sub>λ

1,λ

2</sub>.

4. The health care monitoring system of claim 1, wherein the PPG circuit is configured to:

obtain a value L<sub>λ

1</sub> using a first spectral response around a first wavelength responsive to a color of white blood cells in the arterial blood flow; and

determine a presence of infection from the color of the white blood cells in the arterial blood flow.

5. The health care monitoring system of claim 1, wherein the PPG circuit is configured to:

obtain a first spectral response around a first wavelength responsive to white blood cells in the arterial blood flow; and

determine a spectral pattern using the first spectral response; and

determine a presence of infection from the spectral pattern.

6. The health care monitoring system of claim 1, wherein the biosensor further includes an attachment mechanism for detachment and attachment to the health care band.

7. The health care monitoring system of claim 1, wherein the health care band includes the unique patient identification encoded in a bar code.

8. The health care monitoring system of claim 1, wherein the wireless transceiver is configured to transmit the temperature, oxygen saturation levels, the concentration levels of the one or more additional substances and the unique patient identification to an EMR application server for recording in an electronic medical record associated with the unique patient identification.

9. The health care monitoring system of claim 1, wherein the PPG circuit includes a plurality of photodetectors configured in different physical positions and orientations and coupled in parallel to obtain the plurality of spectral responses at each of the plurality of wavelengths of light reflected from the skin.

10. The health care monitoring system of claim 1, wherein the concentration levels of the one or more additional substances includes two or more of:

a blood alcohol level, a liver enzyme level, a cancer indicating protein, a sodium chloride level, a potassium level, a bilirubin level, and an iron level.

11. A biosensor configured for attachment to a patient, comprising:

a memory configured to store a unique patient identification;

a temperature sensor configured to obtain a temperature of the patient;

a PPG circuit configured for obtaining a concentration level of nitric oxide (NO) of the patient, wherein the PPG circuit is configured to;

generate at least a first spectral response for light reflected around a first wavelength from skin tissue of the patient, wherein the first wavelength is responsive to nitric oxide (NO) levels in arterial blood flow;

generate at least a second spectral response for light detected around a second wavelength reflected from the skin tissue of the patient, wherein the second wavelength has a low absorption coefficient for nitric oxide (NO) in arterial blood flow;

a processing circuit configured to;

process the first and second spectral responses at the first wavelength and the second wavelength;

obtain a glucose concentration level in arterial blood flow using the first and second spectral responses by;

isolating a systolic point and a diastolic point in the first spectral response and obtain a value L<sub>λ

1</sub> using a ratio of the systolic point and the diastolic point in the first spectral response;

isolating a systolic point and a diastolic point in the second spectral response and obtain a value L<sub>λ

2</sub> using a ratio of the systolic point and diastolic point in the second spectral response;

obtaining a value R<sub>λ

1,λ

2</sub> from a ratio of the value L<sub>λ

1</sub> and the value L<sub>λ

2</sub>, wherein the value R<sub>λ

1,λ

2</sub> indicates a concentration level of NO of the patient; and

accessing a calibration table that includes a plurality of glucose concentration levels correlated with a plurality of concentration levels of NO; and

obtaining the glucose concentration level of the patient from the value R<sub>λ

1, λ

2</sub> of the patient and the calibration table; and

a wireless transceiver configured to transmit the temperature, glucose concentration level and the unique patient identification.

12. The biosensor of claim 11, wherein

the value L_λ

1 isolates the first spectral response due to pulsating arterial blood flow; and

wherein the value L<sub>λ

2</sub> isolates the second spectral response due to pulsating arterial blood flow.

13. The biosensor of claim 11, wherein wireless transceiver is configured to transmit the temperature, glucose concentration level and the unique patient identification to an EMR application server for recording in an electronic medical record associated with the unique patient identification.

14. The biosensor of claim 11, wherein the PPG circuit includes a plurality of photodetectors configured in different physical positions and orientations and coupled in parallel to obtain the plurality of spectral responses at each of the plurality of wavelengths of light reflected from the skin.

15. The biosensor of claim 11, wherein the PPG circuit is further configured to obtain a concentration level of one or more additional substances including two or more of:

a blood alcohol level, a liver enzyme level, a cancer indicating protein, a sodium chloride level, a potassium level, a bilirubin level, an iron level and a white blood cell level.

16. The biosensor of claim 11, wherein the biosensor is configured for attachment to a patient on an arm, a wrist, a leg, a finger, a forehead, an earlobe or ear canal.

17. The biosensor of claim 11, wherein the biosensor is further configured to:

determine a position of the biosensor, wherein the position of the biosensor includes at least one area of a body of the patient; and

adjust operation of the PPG circuit in response to the position of the biosensor.

18. The biosensor of claim 17, wherein the processing circuit is configured to determine a position of the biosensor by:

obtaining a spectral response of underlying tissue from the PPG circuit;

detecting one or more characteristics of the underlying tissue from the spectral response;

correlating the detected one or more characteristics of the underlying tissue with predetermined characteristics of underlying tissue from a plurality of body areas, wherein the plurality of body parts include at least;

an abdominal area, wrist, forearm, leg, earlobe or ear canal; and

determining the at least one area of the body of the patient on which the biosensor is located based on the correlation.

19. The biosensor of claim 18, wherein the biosensor is configured to adjust the operation of the PPG circuit in response to the position of the biosensor by:

adjusting a wavelength to transmit to obtain a spectral response to detect a concentration level of a substance in response to the underlying tissue.

20. The biosensor of claim 18, wherein the biosensor is configured to adjust the operation of the PPG circuit in response to the position of the biosensor by:

adjusting an absorption coefficient when determining a concentration level of a substance in response to the underlying tissue.