Neural probe with optical stimulation capability

• US 9,642,545 B2
• Filed: 02/01/2016
• Issued: 05/09/2017
• Est. Priority Date: 11/19/2009
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Yoon, Euisik, Cho, Il-Joo
• Primary Examiner(s): Cohen, Lee S
• Application Number:
  US15/012,334
• Publication Number:
  US 20160143551A1
• Time in Patent Office: 463 Days
• CPC Class Codes: A61B 5/0048 Detecting, measuring or recording by applying mechanical forces or stimuli A61B5/021, A61B5/4884 and A61B9/00 take precedence
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 2005/0612 using probes penetrating tissue; interstitial probes
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 2005/0653 Organic light emitting diodes
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue

Abstract

A neural probe is disclosed for optically stimulating or silencing neurons and recording electrical responses to the stimulus. Using patterning techniques, an integral optical waveguide may be fabricated on the probe for transmitting neuron-affecting light from a light source to a probe tip. The probe tip may include one or more electrodes to receive electrical responses from stimulated neurons for recording or further processing. According to various embodiments, the disclosed neural probes may utilize multiple light sources simultaneously, switch between multiple light sources, or utilize a single light source to stimulate or silence multiple neuron locations simultaneously via multiple probe tips or via multiple light-emitting sites located along the length of the probe. Neural probes are thereby provided that have sufficient spatial resolution to accurately target, stimulate, and record the reaction of neurons, or as few as a single neuron, utilizing a slim, compact structure.

Claims

1. A neural probe, comprising:

a probe body;

a shank extending from the probe body to a tip;

a light-emitting diode (LED) light source attached to the tip for providing neuron-affecting light at said tip, wherein the shank is configured to locate the LED light source at a probing depth to target one or more neurons; and

one or more recording electrodes attached to said tip for receiving electrical responses to the neuron-affecting light.

2. A neural probe as defined in claim 1, wherein the LED light source is located near the one or more recording electrodes.

3. A neural probe as defined in claim 2, wherein the one or more recording electrodes comprise a plurality of recording electrodes, and wherein the LED light source is located between at least some of the plurality of recording electrodes.

4. A neural probe as defined in claim 1, comprising a plurality of LED light sources attached to the tip.

5. A neural probe as defined in claim 4, wherein at least two of the plurality of LED light sources are in a staggered configuration.

6. A neural probe as defined in claim 4, wherein one of the LED light sources is located closer to the tip than at least one other of the LED light sources.

7. A neural probe as defined in claim 4, wherein at least two of the plurality of LED light sources each emit a different wavelength of light than the other.

8. A neural probe as defined in claim 7, wherein one wavelength of light stimulates a neuron and another wavelength of light silences a neuron.

9. A neural probe as defined in claim 4, wherein the plurality of LED light sources have separate electrical connections to control the plurality of LED light sources.

10. A neural probe as defined in claim 9, comprising a plurality of recording electrodes having separate electrical connections, and the electrical connections for the plurality of recording electrodes are located on either side of the electrical connections for the LED light sources.

11. A neural probe as defined in claim 1, wherein the LED light source is an edge-emitting LED for providing neuron-affecting light from a side of the LED light source.

12. A neural probe as defined in claim 1, further comprising an optical waveguide extending from a source end at the probe body to an emitting end near said tip, wherein a second light source is in communication with the source end and the neuron-affecting light is provided at the tip by the emitting end and the LED light source.

13. A neural probe as defined in claim 12, wherein the second light source comprises a fiber optic having a first end in communication with an external light source and a second end abutting the source end of the optical waveguide.

14. A neural probe as defined in claim 12, wherein the second light source comprises an LED light source mounted adjacent the source end of the optical waveguide.

15. A neural probe as defined in claim 1, wherein the LED light source is an organic light-emitting diode (OLED) light source.

16. A neural probe as defined in claim 1, further comprising a second shank extending from the probe body to a second tip and a second light-emitting diode (LED) light source attached to the second tip for providing neuron-affecting light at said second tip.

17. A neural probe as defined in claim 1, wherein the LED light source has an electrical connection patterned on the shank.

18. A neural probe, comprising:

a probe body;

a shank extending from the probe body to a tip;

a light-emitting diode (LED) light source patterned on the shank for providing neuron-affecting light; and

one or more recording electrodes attached to said tip for receiving electrical responses to the neuron-affecting light.

19. A neural probe as defined in claim 18, wherein the patterned LED light source includes a transparent electrode.

20. A neural probe as defined in claim 18, further comprising at least one other LED light source patterned on the shank, and wherein the LED light sources are organic light-emitting diode (OLED) light sources patterned from different OLED materials.

21. A neural probe as defined in claim 18, wherein the one or more recording electrodes have an electrical connection and the LED light source, the recording electrodes, and the electrical connections for the one or more recording electrodes are patterned on an outer surface of the shank.

23. A neural probe as defined in claim 18, comprising a plurality of LED light sources patterned on the shank.

22. A neural probe, comprising:

a probe body;

a shank extending from the probe body to a tip and having an outer perimeter;

a light-emitting diode (LED) light source patterned at the tip for providing neuron-affecting light at said tip; and

a plurality of recording electrodes for receiving electrical responses to the neuron-affecting light, wherein the plurality of recording electrodes are attached to said tip such that they are closer to the outer perimeter of the shank than the LED light source.