System and method for health monitoring using a non-invasive, multi-band biosensor
First Claim
Patent Images
1. A biosensor, comprising:
- a PPG circuit configured to;
emit light having at least a first wavelength responsive to nitric oxide (NO) levels directed at an outer epidermal layer of skin tissue of a patient;
emit light having at least a second wavelength with a low absorption coefficient for nitric oxide (NO) directed at the outer epidermal layer of skin tissue of the patient;
generate a first spectral response for light detected around the first wavelength responsive to NO levels from the outer epidermal layer of the skin tissue of the patient;
generate a second spectral response for light detected around the second wavelength with a low absorption coefficient for NO from the outer epidermal layer of the skin tissue of the patient;
a processing circuit configured to obtain an indicator of a concentration level of NO of the patient, wherein the processing circuit is configured to;
isolate a systolic point and a diastolic point in the first spectral response and obtain a value Lλ
1 using a ratio of the systolic point and the diastolic point in the first spectral response;
isolate a systolic point and a diastolic point in the second spectral response and obtain a value Lλ
2 using a ratio of the systolic point and diastolic point in the second spectral response;
obtain a value Rλ
1,λ
2 from a ratio of the value Lλ
1 and the value Lλ
2, wherein the value Rλ
1,λ
2 is the indicator of the concentration level of NO of the patient;
obtain a blood glucose concentration level of the patient from a calibration table using the value Rλ
1,λ
2, wherein the calibration table includes a range of Rλ
1,λ
2 values and correlated blood glucose concentration levels; and
transmit the blood glucose concentration level of the patient for display.
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Abstract
A biosensor includes a PPG circuit that emits light directed at living tissue at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength and a second wavelength. Using absorption coefficients for substances at the plurality of wavelengths, concentration levels of a plurality of substances may then be determined from the spectral responses. This embodiment of the biosensor may thus be used to determine concentrations of a plurality of substances in arterial blood flow using the spectral response.
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Citations
24 Claims
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1. A biosensor, comprising:
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a PPG circuit configured to; emit light having at least a first wavelength responsive to nitric oxide (NO) levels directed at an outer epidermal layer of skin tissue of a patient; emit light having at least a second wavelength with a low absorption coefficient for nitric oxide (NO) directed at the outer epidermal layer of skin tissue of the patient; generate a first spectral response for light detected around the first wavelength responsive to NO levels from the outer epidermal layer of the skin tissue of the patient; generate a second spectral response for light detected around the second wavelength with a low absorption coefficient for NO from the outer epidermal layer of the skin tissue of the patient; a processing circuit configured to obtain an indicator of a concentration level of NO of the patient, wherein the processing circuit is configured to; isolate a systolic point and a diastolic point in the first spectral response and obtain a value Lλ
1 using a ratio of the systolic point and the diastolic point in the first spectral response;isolate a systolic point and a diastolic point in the second spectral response and obtain a value Lλ
2 using a ratio of the systolic point and diastolic point in the second spectral response;obtain a value Rλ
1,λ
2 from a ratio of the value Lλ
1 and the value Lλ
2, wherein the value Rλ
1,λ
2 is the indicator of the concentration level of NO of the patient;obtain a blood glucose concentration level of the patient from a calibration table using the value Rλ
1,λ
2, wherein the calibration table includes a range of Rλ
1,λ
2 values and correlated blood glucose concentration levels; andtransmit the blood glucose concentration level of the patient for display. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 21, 22, 23, 24)
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10. A biosensor, comprising:
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a PPG circuit configured to; generate at least a first spectral response for light reflected around a first wavelength from skin tissue of the patient, wherein the first wavelength is responsive to nitric oxide (NO) levels in arterial blood flow; generate at least a second spectral response for light detected around a second wavelength reflected from the skin tissue of the patient, wherein the second wavelength has a low absorption coefficient for nitric oxide (NO) in arterial blood flow; a processing circuit configured to obtain a glucose concentration level of the patient, wherein the processing circuit is configured to; obtain a value Lλ
1 using the first spectral response, wherein the value Lλ
1 isolates the first spectral response due to pulsating arterial blood flow;obtain a value Lλ
2 using the second spectral response, wherein the value Lλ
2 isolates the second spectral response due to pulsating arterial blood flow;obtain a value Rλ
1,λ
2 from a ratio of the value Lλ
1 and the value Lλ
2, wherein the value Rλ
1,λ
2 indicates a concentration level of NO of the patient;obtain a base insulin resistance factor based on the value Rλ
1,λ
2 that indicates a diabetic risk indicator;a wireless transceiver configured to transmit the diabetic risk indicator to a remote device. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for health monitoring, comprising:
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generating at least a first spectral response for light reflected around a first wavelength from skin tissue of the patient, wherein the first wavelength is responsive to nitric oxide (NO) levels in arterial blood flow; generating at least a second spectral response for light detected around a second wavelength reflected from the skin tissue of the patient, wherein the second wavelength has a low absorption coefficient for nitric oxide (NO) in arterial blood flow; obtaining a value Lλ
1 using the first spectral response, wherein the value Lλ
1 isolates the first spectral response due to pulsating arterial blood flow;obtaining a value Lλ
2 using the second spectral response, wherein the value Lλ
2 isolates the second spectral response due to pulsating arterial blood flow;obtaining a value Rλ
1,λ
2 from a ratio of the value Lλ
1 and the value Lλ
2, wherein the value Rλ
1,λ
2 indicates a concentration level of NO of the patient;obtaining a base insulin resistance factor based on the value Rλ
1,λ
2 that indicates a diabetic risk indicator; andtransmitting the diabetic risk indicator to a remote device.
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Specification