Devices and methods for control of blood pressure

• US 9,642,726 B2
• Filed: 04/24/2012
• Issued: 05/09/2017
• Est. Priority Date: 07/25/2005
• Status: Active Grant

• Current Assignee: Vascular Dynamics Inc.
• Original Assignee: Vascular Dynamics Inc.
• Inventors: Gross, Yossi, Avneri, Itzik, Weisberg, Ori, Eshkol, Moshe, Oren, Tal, Assaf, Yaron, Feld, Tanhum, Elazar, Moshe
• Primary Examiner(s): Sevilla, Christian
• Assistant Examiner(s): WOLF, MEGAN YARNALL
• Application Number:
  US13/455,005
• Publication Number:
  US 20130172981A1
• Time in Patent Office: 1,841 Days
• Field of Search: 623 115, 623 116, 623 124, 623 126, 623 13, 623 135
• CPC Class Codes: A61B 5/0053 by applying pressure, e.g. compression, indentation, palpation, grasping, gauging
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2230/0021 square
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2250/0059 temporary

Abstract

Apparatus and methods are described including an implantable device having first and second longitudinal ends, the device having a length of less than 80 mm when the device is unconstrained. The device includes struts arranged such that, when the device is unconstrained, along a continuous portion of the device having a length that is at least 5 mm, a maximum inter-strut distance defined by any set of two adjacent struts is more than 1.5 times as great as a maximum inter-strut distance defined by any set of two adjacent struts within longitudinal portions of the device within 3 mm of the longitudinal ends of the device. Other applications are also described.

Claims

1. A method of stimulating baroreceptors to treat a disease, the method comprising:

providing an implantable device comprising;

a proximal end portion comprising a plurality of proximal struts extending along four proximal arches,

a distal end portion comprising a plurality of distal struts extending along four distal arches, and

a central portion arranged between the proximal and distal end portions and comprising a longitudinal length of at least 5 mm, the central portion comprising four central struts and four continuous open regions; and

implanting the device in a carotid artery of a subject,

wherein the four central struts contact a wall of the carotid artery and flatten and stretch the wall at the four open regions,

wherein the four proximal arches and the four distal arches resist pressure exerted by the wall of the carotid artery on the four central struts,

wherein flattening and stretching of the wall at the four open regions stimulate the baroreceptors and treat the disease, and

wherein the flattening and stretching causes the wall to form alternating device contact regions and device non-contact regions, the device non-contact regions having a first radius of curvature and the device contact regions having a second radius of curvature less than the first radius of curvature.

2. The method according to claim 1, further comprising identifying the subject as suffering from hypertension, wherein implanting the device in the subject'"'"'s carotid artery comprises lowering blood pressure of the subject.

3. The method according to claim 1, wherein each of the four continuous open regions of the device comprises a region of the device that defines no struts, the region having a non-circular shape.

4. The method according to claim 1, wherein the device has a length of less than 50 mm.

5. The method according to claim 1, wherein the device has a spring constant of less than 2 N/mm.

6. The method according to claim 5, wherein the device has a spring constant of less than 1.5 N/mm.

7. The method according to claim 1, wherein the maximum inter-strut distance between any two adjacent struts of the four central struts-defines an arc of more than 30 degrees around a longitudinal axis of the device.

8. The method according to claim 7, wherein the maximum inter-strut distance between any two adjacent struts of the four central struts-defines an arc of more than 60 degrees around the longitudinal axis of the device.

9. A method of stimulating baroreceptors to treat a disease, comprising:

providing an implantable device comprising;

a proximal end portion comprising a plurality of proximal struts extending along four proximal arches,

a distal end portion comprising a plurality of distal struts extending along four distal arches, and

a central portion arranged between the proximal and distal end portions and comprising a longitudinal length of at least 5 mm, the central portion comprising four central struts and four continuous open regions,

wherein when the device is unconstrained, a maximum inter-strut distance between any two adjacent struts of the four central struts is more than 5 mm; and

implanting the device in a carotid artery of a subject, wherein the four central struts contact a wall of the carotid artery and flatten and stretch the wall at the four open regions,

wherein the four proximal arches and the four distal arches resist pressure exerted by the wall of the carotid artery on the four central struts,

wherein flattening and stretching of the wall at the four open regions stimulate the baroreceptors and treat the disease, and

wherein the flattening and stretching causes the wall to form alternating device contact regions and device non-contact regions, the device non-contact regions having a first radius of curvature and the device contact regions having a second radius of curvature less than the first radius of curvature.

10. The method according to claim 9, further comprising identifying the subject as suffering from hypertension, wherein implanting the device in the subject'"'"'s carotid artery comprises lowering blood pressure of the subject.

11. The method according to claim 9, wherein each of the four continuous open regions of the device comprises a region of the device that defines no struts, the region having a non-circular shape.

12. The method according to claim 9, wherein the device has a length of less than 50 mm.

13. The method according to claim 9, wherein the device has a spring constant of less than 2 N/mm.

14. The method according to claim 13, wherein the device has a spring constant of less than 1.5 N/mm.

15. The method according to claim 9, wherein the maximum inter-strut distance between any two adjacent struts of the four central struts-defines an arc of more than 30 degrees around a longitudinal axis of the device.

16. The method according to claim 15, wherein the maximum inter-strut distance between any two adjacent struts of the four central struts-defines an arc of more than 60 degrees around the longitudinal axis of the device.