Bone cement and methods of use thereof

• US 9,642,932 B2
• Filed: 09/11/2007
• Issued: 05/09/2017
• Est. Priority Date: 09/14/2006
• Status: Active Grant

• Current Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Inventors: Beyar, Mordechay, Globerman, Oren
• Primary Examiner(s): PEPITONE, MICHAEL F
• Application Number:
  US12/377,894
• Publication Number:
  US 20100168271A1
• Time in Patent Office: 3,528 Days
• Field of Search: 523105, 523115, 523116, 525193, 525308, 525309, 525937, 623 2362
• CPC Class Codes: A61K 6/15 Compositions characterised by their physical properties
• CPC Class Codes: A61L 24/0005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate

Abstract

A bone cement comprising an acrylic polymer mixture which is formulated to have a relatively high viscosity for a relatively long window, due to distributions of molecular weights and/or sizes of acrylic beads.

Claims

1. A cement kit, comprising:

(a) a liquid component including a monomer; and

(b) a powder component including polymeric beads,

in which the distribution of the molecular weight of the powder component is non-normal so that it is skewed to a higher molecular weight by introduction of higher molecular weight beads, the non-normal distribution of the molecular weight of the powder component causing (a) an increase in the immediate viscosity of a mixture of the liquid and powder components and compared with a cement having a substantially normal distribution, and (b) an increase in the length of the working window period in which the viscosity of the cement does not exceed 500 Pa.s compared with a cement having a substantially normal distribution.

2. A cement kit according to claim 1, in which the higher molecular weight beads have an average molecular weight of at least a factor of 2 of an average molecular weight of the polymeric beads.

3. A cement kit according to claim 2, in which the factor is at least 3.

4. A cement kit according to claim 3, in which the factor is at least 5.

5. A cement kit according to claim 1, further comprising a relatively small component including smaller sized beads.

6. A cement kit according to claim 1, wherein the polymeric beads comprise PMMA.

7. A cement kit according to claim 1, wherein the higher molecular weight beads have a molecular weight of about 600,000 Dalton to about 5,000,000 Dalton.

8. A cement kit according to claim 1, wherein the higher molecular weight beads have a molecular weight of about 3,000,000 to 4,000,000 Dalton.

9. A cement kit according to claim 1, wherein the higher molecular weight beads have a molecular weight of about 3,500,000 to 3,900,000 Dalton.

10. A cement kit according to claim 1, wherein an average molecular weight of the polymeric beads is about 130,000 to 170,000 Dalton.

11. A cement kit according to claim 1, wherein an average molecular weight of the polymeric beads is about 375,000 Dalton.