Medical composition and medical kit
First Claim
Patent Images
1. A medical composition for injection, the composition comprising:
- a carrier in particle form, the carrier having (i) a support made from a bioabsorbable polymer particle and (ii) a surface layer made from hydroxyapatite nanocrystal particles, which have diameters of 25 nm to 500 nm, and provided on the support, wherein the particle diameter of the carrier is not less than 10 μ
m and not greater than 200 μ
m; and
a sufficient number of cells, which are effective to generate new blood vessels in a living subject, said cells being adhered directly onto the surface layer of the carrier by adhesive ability of said cells by mixing said carrier and said cells in such a manner that the number, per carrier, of said cells to be mixed is less than or equal to 1×
1010;
wherein the composition does not contain gelatin,wherein the ratio by weight of said carrier to said cells is from 1/10 to 10/1, andwherein said cells are myelomonocytic cells.
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Abstract
In order to provide (i) a medical composition that has a strong angiogenic effect, has low invasiveness to a body of a patient, and is easy to administer to a living subject and (ii) a medical kit using a medical composition, the medical composition includes: a carrier in a particle form, the carrier having (a) a support made from a bioabsorbable polymer and (b) a surface layer made from hydroxyapatite and provided on the support; and cells provided on a surface of the carrier.
16 Citations
8 Claims
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1. A medical composition for injection, the composition comprising:
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a carrier in particle form, the carrier having (i) a support made from a bioabsorbable polymer particle and (ii) a surface layer made from hydroxyapatite nanocrystal particles, which have diameters of 25 nm to 500 nm, and provided on the support, wherein the particle diameter of the carrier is not less than 10 μ
m and not greater than 200 μ
m; anda sufficient number of cells, which are effective to generate new blood vessels in a living subject, said cells being adhered directly onto the surface layer of the carrier by adhesive ability of said cells by mixing said carrier and said cells in such a manner that the number, per carrier, of said cells to be mixed is less than or equal to 1×
1010;wherein the composition does not contain gelatin, wherein the ratio by weight of said carrier to said cells is from 1/10 to 10/1, and wherein said cells are myelomonocytic cells. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of producing a medical composition, which does not contain gelatin, the method comprising mixing a carrier in particle form and a sufficient number of cells in such a manner that the number, per carrier, of said cells to be mixed is less than or equal to 1×
- 1010, the carrier having (i) a support made from a bioabsorbable polymer particle and (ii) a surface layer made from hydroxyapatite nanocrystal particles, which have diameters of 25 nm to 500 nm, and provided on the support;
wherein the particle diameter of the carrier is not less than 10 μ
m and not greater than 200 μ
m, and wherein the ratio by weight of said carrier to said cells is from 1/10 to 10/1 and said cells are myelomonocytic cells;
such that said sufficient number of cells, which are effective to generate new blood vessels in a living subject, are caused to adhere directly onto the surface layer of said carrier by adhesive ability of the cells.
- 1010, the carrier having (i) a support made from a bioabsorbable polymer particle and (ii) a surface layer made from hydroxyapatite nanocrystal particles, which have diameters of 25 nm to 500 nm, and provided on the support;
Specification