Macroporous and highly resorbable apatitic calcium-phosphate cement

• US 9,642,939 B2
• Filed: 08/23/2007
• Issued: 05/09/2017
• Est. Priority Date: 08/24/2006
• Status: Active Grant

• Current Assignee: Graftys Co., Universite De Nantes
• Original Assignee: Graftys Co., Universite De Nantes
• Inventors: Khairoun, Ibrahim, Weiss, Pierre, Bouler, Jean-Michel
• Primary Examiner(s): Javier, Melissa
• Application Number:
  US12/438,598
• Publication Number:
  US 20100068243A1
• Time in Patent Office: 3,547 Days
• Field of Search: None
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/0042 Materials resorbable by the body
• CPC Class Codes: A61L 24/0063 Phosphorus containing materials, e.g. apatite
• CPC Class Codes: A61L 24/0084 containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.

Claims

1. An injectable calcium phosphate cement comprising one or more calcium phosphate compounds, microparticles of hydroxypropylmethylcellulose (HPMC) with a diameter between 20 and 300 μ

m, and an aqueous solution of Na₂HPO₄;

wherein the one or more calcium phosphate compounds comprises at least 70 % of an α

-tricalcium phosphate (α

-TCP);

and wherein the calcium phosphate cement is made by forming a power mixture comprising the one or more calcium phosphate compounds, the HPMC in an amount of about 1% to about 3% by weight of the total amount of the cement powder, and the α

-TCP and then mixing the resulting powder mixture with the aqueous solution of Na2HPO4 to form the injectable calcium phosphate cement.

2. The injectable calcium phosphate cement according to claim 1, wherein said calcium phosphate compounds are selected from the group consisting of hydroxyapatite (HA), amorphous calcium phosphate (ACP), monocalcium phosphate monohydrate (MCPH), dicalcium phosphate dihydrate (DCPD), dicalcium phosphate anhydrous (DCPA), precipitated or calcium-deficient apatite (CDA), α

-tricalcium phosphate (α

-TCP), β

-tricalcium phosphate (β

-TCP), tetracalcium phosphate (TTCP), and mixtures thereof.

3. The injectable calcium phosphate cement according to claim 2, wherein said calcium phosphate compounds are selected from the group consisting of α

-TCP, MCPH, DCPD, and mixtures thereof.

4. The injectable calcium phosphate cement according to claim 1, wherein said calcium phosphate compounds consists of α

-TCP and DCPD.

5. The injectable calcium phosphate cement according to claim 1, wherein said power mixture consists of a mixture of α

-TCP, DCPD, and HPMC.

6. The injectable calcium phosphate cement according to claim 1, wherein the aqueous solution of Na2HPO4 and powder mixture is in a ratio of about 0.3to about 0.6 mL/g.

7. The injectable calcium phosphate cement according to claim 1, further comprising one or more ingredients selected from the group of antibiotics, anti-inflammatory drugs, anti-cancer drugs, drugs against osteoporosis, and growth factors.

8. A scaffold for tissue engineering comprising the injectable calcium phosphate cement according to claim 1.

9. A dental or bony implant consisting of a molding of the injectable calcium phosphate cement according to claim 1.