Automated ultrasound mediated delivery

• US 9,643,000 B2
• Filed: 08/29/2012
• Issued: 05/09/2017
• Est. Priority Date: 09/28/2011
• Status: Active Grant

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Seip, Ralf, Raju, Balasundar Iyyavu, Leyvi, Evgeniy
• Primary Examiner(s): OSINSKI, BRADLEY JAMES
• Application Number:
  US14/347,904
• Publication Number:
  US 20140249469A1
• Time in Patent Office: 1,714 Days
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

Bubble presence within a region is monitored to determine if a predetermined condition is met such as whether the presence is of sufficient magnitude, the bubbles being subject to energizing (240). In some embodiments, the energizing only occurs when time- wise preceded by the determination (S508, S510). The determining can include measuring a grayscale value (104), or assessing the energy carried by a frequency component of the echo signal, in the region in real time. The energizing may occur region-by-region, automatically and without need for user intervention, in a treatment pass (S428) over the regions. The regions (232) in the pass might be subject to respective instances of the energizing without intervening monitoring, or, in another embodiment, to both the determining and the responsive energizing. The determining can be subject to, automatically and without need for user intervention, interruption (S408) and concurrent switching to a next region.

Claims

1. A device comprising:

an imaging module configured for monitoring, according to each iteration of a number of iterations of a treatment plan, a current treatment region of a plurality of treatment regions over an entire treatment area, to determine whether bubble presence in the current treatment region meets a predefined threshold of a magnitude of said bubble presence; and

a unit configured for energizing bubbles within said current treatment region to deliver a substance,

wherein said energizing bubbles (i) occurs in real time response to a determination that said predefined threshold has been met for the current treatment region, and (ii) is skipped for the current treatment region in real time response to the determination that said predefined threshold has not been met, further wherein subsequently the imaging module and the energizing unit proceed with a next treatment region until all of the plurality of treatment regions of the entire treatment area for the number of iterations of the treatment plan receive deliver of the substance, and wherein if said energizing bubbles is skipped for the current treatment region in response to the determination that said predefined threshold has not been met, the imaging module and the energizing unit are configured to return to the current treatment region to determine whether bubble presence in the current treatment region meets the predefined threshold after determination of bubble presence is made for the next treatment region.

2. The device of claim 1, wherein further said energizing bubbles within said current treatment region occurs only when immediately time-wise preceded by the determination.

3. The device of claim 1, wherein monitoring to determine comprises measuring a grayscale value in said current treatment region in real time.

4. The device of claim 1, wherein monitoring to determine is based on real-time, frequency-specific information derived from imaging of said current treatment region.

5. The device of claim 1, wherein energizing occurs region-by-region, automatically and without need for user intervention, in a treatment pass over the plurality of treatment regions.

6. The device of claim 5, wherein the plurality of treatment regions in said treatment pass are subject to respective instances of said energizing without intervening monitoring.

7. The device of claim 5, wherein the plurality of treatment regions in said treatment pass are respectively subject to both the determining and the responsive energizing).

8. The device of claim 7, further wherein said determining is subject to, automatically and without need for user intervention, interruption and concurrent switching to a next treatment region.

9. The device of claim 8, further wherein said interruption is, automatically and without need for user intervention, concurrent with adding said current treatment region to a list maintained by said device.

10. The device of claim 9, further comprising a controller for, automatically and without need for user intervention, periodically switching said monitoring from a treatment region not on said list to a treatment region on said list.

11. The device of claim 9, further wherein the imaging module performs said monitoring, by treatment region, in an order that accords priority to the plurality of treatment regions that, in a prior treatment pass, were on said list.

12. The device of claim 11, wherein said order comprises an initial order, subject to said interruption and said concurrent switching.

13. The device of claim 1, further wherein the unit, automatically and without need for user intervention, based on tissue dynamics derived from a result of monitoring that has occurred in a prior treatment pass, adaptively energizes bubbles within said current treatment region.

14. The device of claim 13, further wherein the unit adaptively skips the current treatment region.

15. The device of claim 1, further comprising a controller for, automatically and without need for user intervention:

a) initiating said monitoring in a current treatment pass;

b) deriving, from said monitoring in said current treatment pass, a result; and

c) based on said result, completing, without need for further monitoring, the treatment plan.

16. The device of claim 15, wherein said result comprises a three-dimensional reperfusion map.

17. The device of claim 1, further comprising a controller for, automatically and without need for user intervention, making, based on a result derived from said monitoring, an estimate of remaining treatment time and for outputting said estimate to a user of said device.

18. The device of claim 1, wherein said energizing comprises delivering acoustic energy.

19. A non-transitory computer readable medium embodied with instructions executable by a processor for carrying out a series of acts for a substance delivery device, the acts comprising:

monitoring, according to each iteration of a number of iterations of a treatment plan, a current treatment region of a plurality of treatment regions over an entire treatment area, to determine whether bubble presence in the current treatment region meets a predefined magnitude of said bubble presence; and

energizing bubbles within said current treatment region to deliver a substance,

wherein said energizing bubbles (i) occurs in real time response to a determination that said predefined magnitude has been met for the current treatment region, and (ii) is skipped for the current treatment region in real time response to the determination that said predefined magnitude has not been met, further wherein subsequently the monitoring and the energizing proceed with a next treatment region until all of the plurality of treatment regions of the entire treatment area for the number of iterations of the treatment plan receive deliver of the substance, and wherein if said energizing bubbles is skipped for the current treatment region in response to the determination that said predefined threshold has not been met, returning to the current treatment region to determine whether bubble presence in the current treatment region meets the predefined threshold after determination of bubble presence is made for the next treatment region.

20. The non-transitory computer readable medium of claim 19, wherein further said energizing bubbles within said current treatment region occurs only when immediately time-wise preceded by the determination.

21. The non-transitory computer readable medium of claim 19, wherein monitoring to determine comprises measuring a grayscale value in said current treatment region in real time.

22. The non-transitory computer readable medium of claim 19, wherein monitoring to determine is based on real-time, frequency-specific information derived from imaging of said current treatment region.

23. The non-transitory computer readable medium of claim 19, wherein said energizing occurs region-by-region, automatically and without need for user intervention, in a treatment pass over the plurality of treatment regions.

24. The non-transitory computer readable medium of claim 23, wherein the plurality of treatment regions in said treatment pass are subject to respective instances of said energizing without intervening monitoring.

25. The non-transitory computer readable medium of claim 23, wherein the plurality of treatment regions in said treatment pass are respectively subject to both the determining and the responsive energizing.

26. The non-transitory computer readable medium of claim 25, further wherein said determining is subject to, automatically and without need for user intervention, interruption and concurrent switching to a next treatment region.

27. The non-transitory computer readable medium of claim 26, further wherein said interruption is, automatically and without need for user intervention, concurrent with adding said current treatment region to a list maintained by said device.