Use of PDL1 expressing cells to convert T cells into regulatory T cells
First Claim
1. A method of converting a pathogenic T cell into a cell that exhibits a regulatory T cell phenotype, the method comprising contacting the pathogenic T cell with a K562 cell modified to express an agent selected from the group consisting of PDL1, PDL2, and an anti-PD1 antibody, thereby converting said pathogenic T cell into a cell that exhibits a regulatory T cell phenotype.
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Abstract
The present invention provides methods and compositions for converting a T cell into a cell that exhibits at least one regulatory T cell phenotype. The converted T cell is generated by contacting a T cell with a cell that is modified to comprise an agent capable of activating PD1 signaling in a T cell. The converted T cell is useful for preventing, suppressing, blocking or inhibiting an immune response. For example the converted T cell is useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft versus host disease. The converted T cell can also be used to treat autoimmune diseases.
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Citations
6 Claims
- 1. A method of converting a pathogenic T cell into a cell that exhibits a regulatory T cell phenotype, the method comprising contacting the pathogenic T cell with a K562 cell modified to express an agent selected from the group consisting of PDL1, PDL2, and an anti-PD1 antibody, thereby converting said pathogenic T cell into a cell that exhibits a regulatory T cell phenotype.
Specification