Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof

• US 9,646,377 B2
• Filed: 04/02/2014
• Issued: 05/09/2017
• Est. Priority Date: 01/19/2006
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Tearney, Guillermo J., Shishkov, Milen, Bouma, Brett Eugene, Vakoc, Benjamin J., Nishioka, Norman S.
• Primary Examiner(s): REMALY, MARK DONALD
• Application Number:
  US14/243,508
• Publication Number:
  US 20140301620A1
• Time in Patent Office: 1,133 Days
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence
• CPC Class Codes: G06T 2207/10056 Microscopic image
• CPC Class Codes: G06T 2207/10101 Optical tomography; Optical coherence tomography [OCT]
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

Claims

1. An apparatus for determining a position on or in a biological tissue, comprising:

at least one computer arrangement which is configured to;

receive first data associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique,

based on the first data, cause a visible change on or in at least location of the at least one portion using at least one electro-magnetic radiation, and

using image second data for the visible change on or in the at least one location, automatically effectuate a removal or a destruction of at least part of the at least one portion.

2. The apparatus according to claim 1, wherein the image second data is visible image data.

3. The apparatus according to claim 1, wherein the at least one arrangement is further configured to obtain the image second data after the visible change is effectuated.

4. The apparatus according to claim 1, wherein the at least one image includes a volumetric image of the at least one portion.

5. The apparatus according to claim 4, wherein the volumetric image is a cylindrical image having at least one (i) a diameter of between about 10 mm to 100 mm, or (ii) an extension of at most about 1 m.

6. The apparatus according to claim 4, further comprising at least one further computer arrangement which is configured to receive data associated with the visible change, and guide a visualization to the at least one portion based on the data.

7. The apparatus according to claim 1, wherein the at least one computer arrangement causes the visible change by ablating the at least one portion.

8. The apparatus according to claim 7, wherein the ablation of the at least one portion is performed by irradiating the at least one portion with the at least one electro-magnetic radiation.

9. The apparatus according to claim 1, wherein the optical imaging technique includes an optical coherence tomography.

10. The apparatus according to claim 1, wherein the at least one computer arrangement is situated in a probe, and further comprising an ablation radiation laser source arrangement provided in the probe which is controlled by the at least one computer arrangement to cause the visible change on or in the at least one portion.

11. The apparatus according to claim 10, wherein the at least one computer arrangement is configured to obtain the information via at least one wave-guiding arrangement, and the ablation radiation laser source arrangement provides the at least one electro-magnetic radiation via the at least one wave-guiding arrangement to cause the visible change.

12. The apparatus according to claim 1, wherein the optical imaging technique includes a confocal microscopy technique.

13. The apparatus according to claim 12, wherein the confocal microscopy technique is a spectrally-encoded confocal microscopy technique.

14. A method for determining a position on or in a biological tissue, comprising:

with a computer, receiving first data associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique,

based on the first data, causing a visible change on or in at least location of the at least one portion using at least one electro-magnetic radiation, and

using image second data for the visible change on or in the at least one location, automatically effectuating a removal or a destruction of at least part of the at least one portion.