Biomedical parameter probabilistic estimation method and apparatus
First Claim
1. An apparatus for electrodynamic analysis of a body comprising a heart, the apparatus comprising:
- a digital signal processor integrated into a biomedical device, said digital signal processor configured to use;
an electrodynamics dynamic state-space model and a probabilistic processor to produce an initial posterior probability distribution function using input from both an optical hemodynamic waveform measurement generated using output from an optical probe and an electrodynamic signal from an electrocardiogram of the heart of the body; and
a probabilistic updater configured to generate a time varying aortic pressure waveform using all of;
(1) iterative input of a prior probability distribution function, the prior probability distribution function comprising a previous iteration output of a posterior probability distribution function from the electrodynamics dynamic state-space model, (2) iterative optical hemodynamic waveform measurement input generated using the optical probe, and (3) iterative electrodynamic signal from the electrocardiogram of the body,wherein said electrodynamics dynamic state-space model comprises;
a process model, wherein said process model comprises a model describing electric charge transfer in the body.
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Abstract
A probabilistic digital signal processor is described. Initial probability distribution functions are input to a dynamic state-space model, which operates on state and/or model probability distribution functions to generate a prior probability distribution function, which is input to a probabilistic updater. The probabilistic updater integrates sensor data with the prior to generate a posterior probability distribution function passed (1) to a probabilistic sampler, which estimates one or more parameters using the posterior, which is output or re-sampled in an iterative algorithm or (2) iteratively to the dynamic state-space model. For example, the probabilistic processor operates using a physical model on data from a mechanical system or a medical meter or instrument, such as an electrocardiogram. Output of the physical model yields an enhanced output of the original data, an output to a second physical parameter not output by the medical meter, or a prediction, such as an arrhythmia warning.
58 Citations
21 Claims
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1. An apparatus for electrodynamic analysis of a body comprising a heart, the apparatus comprising:
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a digital signal processor integrated into a biomedical device, said digital signal processor configured to use; an electrodynamics dynamic state-space model and a probabilistic processor to produce an initial posterior probability distribution function using input from both an optical hemodynamic waveform measurement generated using output from an optical probe and an electrodynamic signal from an electrocardiogram of the heart of the body; and a probabilistic updater configured to generate a time varying aortic pressure waveform using all of;
(1) iterative input of a prior probability distribution function, the prior probability distribution function comprising a previous iteration output of a posterior probability distribution function from the electrodynamics dynamic state-space model, (2) iterative optical hemodynamic waveform measurement input generated using the optical probe, and (3) iterative electrodynamic signal from the electrocardiogram of the body,wherein said electrodynamics dynamic state-space model comprises; a process model, wherein said process model comprises a model describing electric charge transfer in the body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for electrodynamic analysis of a body comprising a heart, the method comprising the steps of:
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providing a digital signal processor integrated into a biomedical device, said digital signal processor configured to use; an electrodynamics dynamic state-space model; and a probabilistic processor; said probabilistic processor producing an initial posterior probability distribution function using input from both a photoplethysmogram signal generated using output from an optical probe and an electrodynamic signal from an electrocardiogram of the heart of the body; a probabilistic updater generating a time varying aortic pressure waveform using all of; (1) iterative input of a prior probability distribution function, the prior probability distribution function comprising a previous iteration output of a posterior probability distribution function from the electrodynamics dynamic state-space model, (2) iterative optical photoplethysmographic signal generated using the optical probe, and (3) iterative electrodynamic signal originating in the heart of the body, wherein said electrodynamics dynamic state-space model comprises; a process model relating both the photoplethysmogram signal and the electrodynamic signal originating in the body to systolic contraction. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. A method for electrodynamic analysis of a heart of a body, comprising the steps of:
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providing a digital signal processor integrated into a biomedical device, said digital signal processor producing an initial posterior probability distribution function using input from (1) a photoplethysmogram and (2) a probability distribution function using a physical model representative of a compartment of the heart of the body; a probabilistic updater, of said digital processor, subsequently generating a time varying aortic pressure waveform using all of;
(1) iterative input of a prior probability distribution function, the prior probability distribution function comprising a previous iteration output of a posterior probability distribution function generated using the physical model, (2) iterative input from the photoplethysmogram, and (3) iterative electrodynamic signal originating in the body,wherein said physical model comprises; a process model configured to; model electric charge transfer in the heart; and use at least one equation relating a heart contraction state to at least one of; an atrium potential variable; a ventricle potential variable. - View Dependent Claims (20, 21)
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Specification