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Biomedical parameter probabilistic estimation method and apparatus

  • US 9,649,036 B2
  • Filed: 04/28/2011
  • Issued: 05/16/2017
  • Est. Priority Date: 04/22/2009
  • Status: Active Grant
First Claim
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1. An apparatus for electrodynamic analysis of a body comprising a heart, the apparatus comprising:

  • a digital signal processor integrated into a biomedical device, said digital signal processor configured to use;

    an electrodynamics dynamic state-space model and a probabilistic processor to produce an initial posterior probability distribution function using input from both an optical hemodynamic waveform measurement generated using output from an optical probe and an electrodynamic signal from an electrocardiogram of the heart of the body; and

    a probabilistic updater configured to generate a time varying aortic pressure waveform using all of;

    (1) iterative input of a prior probability distribution function, the prior probability distribution function comprising a previous iteration output of a posterior probability distribution function from the electrodynamics dynamic state-space model, (2) iterative optical hemodynamic waveform measurement input generated using the optical probe, and (3) iterative electrodynamic signal from the electrocardiogram of the body,wherein said electrodynamics dynamic state-space model comprises;

    a process model, wherein said process model comprises a model describing electric charge transfer in the body.

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