Medical devices for mapping cardiac tissue

• US 9,649,040 B2
• Filed: 10/02/2015
• Issued: 05/16/2017
• Est. Priority Date: 10/03/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Laughner, Jacob I., Kovtun, Vladimir V., Shome, Shibaji, Shuros, Allan C., Ricci, Carlos Alberto, Stalsberg, Kevin J., Thakur, Pramodsingh H.
• Primary Examiner(s): Wieland, Robert N
• Application Number:
  US14/873,800
• Publication Number:
  US 20160183809A1
• Time in Patent Office: 592 Days
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/347 Detecting the frequency distribution of signals
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/367 Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: A61B 5/7253 characterised by using transforms
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

Medical devices and methods for making and using medical devices are disclosed. An example system for mapping the electrical activity of the heart includes a catheter shaft. The catheter shaft includes a plurality of electrodes including a first electrode and a second electrode. The system also includes a processor. The processor is capable of collecting a first signal corresponding to the first electrode and a second signal corresponding to the second electrode. Collecting the first and second signals occurs over a time period. The processor is also capable of generating a first time-frequency distribution corresponding to the first signal, identifying a first dominant frequency value occurring at a first dominant frequency and a first time point, generating a second time-frequency distribution corresponding to the second signal, identifying a second dominant frequency value occurring at a second dominant frequency and a second time point and determining an attraction point.

Claims

1. A system for mapping the electrical activity of the heart, the system comprising:

a catheter shaft, wherein a plurality of electrodes is coupled thereto, and wherein the plurality of electrodes includes a first electrode and a second electrode;

a processor, wherein the processor is configured to;

receive a first signal corresponding to the first electrode and a second signal corresponding to the second electrode, wherein collecting the first and second signals occurs over a time period;

generate a first time-frequency distribution corresponding to the first signal;

identify a first dominant frequency value occurring at a first dominant frequency and a first time point;

generate a second time-frequency distribution corresponding to the second signal;

identify a second dominant frequency value occurring at a second dominant frequency and a second time point;

determine an attraction point, wherein the attraction point is defined when the first dominant frequency value substantially relates to the second dominant frequency value;

identify a frequency interval that includes the determined attraction point, wherein the frequency interval includes the first and the second dominant frequency values, and wherein the first dominant frequency value substantially relates to the second dominant frequency value over the frequency interval; and

output the identified frequency interval to a visual display.

2. The system of claim 1, wherein to generate the first frequency distribution and the second frequency distribution, the processor is configured to utilize at least one Fourier transform, Short-Time Fourier transform, or a Wavelet transform.

3. The system of claim 1, wherein to generate the first frequency distribution and/or the second frequency distribution, the processor is configured to generate a spectrogram of the first signal and/or the second signal.

4. The system of claim 1, wherein the first or second dominant frequency value is substantially equal to a maximum frequency value, a chirp, a sustained maximum frequency value, a local maximum frequency value and/or a dominant frequency characteristic.

5. The system of claim 1, the processor being further configured to determine a dominant frequency threshold value, wherein the maximum frequency value and/or the local maximum frequency value is greater than or substantially equal to the dominant frequency threshold value.

6. The system of claim 1, wherein the first dominant frequency is substantially equal to the second dominant frequency, and wherein the first dominant time point is substantially equal to the second dominant time point.

7. The system of claim 1, the processor being further configured to identify a time interval, wherein the time interval includes the first and second time points, and wherein the first dominant frequency value substantially relates to the second dominant frequency value over the time interval.

8. The system of claim 1, the processor being further configured to collect a signal from a third electrode over a time period, wherein the processor generates a third dominant frequency value and wherein the attraction point is defined when the first, second and third dominant frequency values substantially relate to each other.

9. The system of claim 8, the processor being further configured to collect a signal from a third electrode over a time period, wherein the processor generates a third dominant frequency value and wherein the frequency interval includes the first, the second and the third dominant frequency values, and wherein the first, second and third dominant frequency values substantially relate to each other over the frequency interval.

10. The system of claim 1, wherein the first time-frequency distribution, the second time-frequency distribution, or both time-frequency distributions include a plurality of attraction points that define a plurality of modes of electrical activation patterns corresponding to an anatomical feature.

11. The system of claim 10, the processor being further configured to deconstruct the plurality of modes so that a tailored therapy can be directed to the electrical activation pattern and corresponding anatomical feature.

12. A system for mapping the electrical activity of the heart, the system comprising:

a catheter shaft;

a plurality of electrodes coupled to the catheter shaft; and

a processor coupled to the catheter shaft, wherein the processor is configured to;

receive a plurality of signals corresponding to signals sensed by the plurality of electrodes;

generate a time-frequency distribution for each of the plurality of signals;

identify a common dominant frequency of more than one of the plurality of electrodes, wherein the common dominant frequency occurs at a common dominant time point common to the one or more of the plurality of electrodes, and wherein to identify a common dominant frequency includes determining an attraction point, wherein the attraction point is defined when the common dominant frequency characteristic, the common dominant frequency and the common dominant time point are substantially equivalent; and

create a visual display corresponding to the common dominant frequency.

13. The system of claim 12, wherein the dominant frequency characteristic includes a maximum frequency value, a chirp, a sustained maximum frequency value or a local maximum frequency.

14. The system of claim 12, wherein to create a visual display the processor is configured to create a phase map.

15. The system of claim 14, wherein the phase map displays one or more sinusoids corresponding to the plurality of signals or derivatives thereof.

16. A method for mapping the electrical activity of the heart, the method comprising:

collecting a first signal corresponding to the first electrode and a second signal corresponding to the second electrode, wherein collecting the first and second signals occurs over a time period, and wherein the first and second signals are collected with a catheter having a plurality of electrodes;

generating a first time-frequency distribution corresponding to the first signal;

identifying a first dominant frequency value occurring at a first dominant frequency and a first time point;

generating a second time-frequency distribution corresponding to the second signal;

identifying a second dominant frequency value occurring at a second dominant frequency and a second time point;

determining an attraction point, wherein the attraction point is defined when the first dominant frequency value substantially relates to the second dominant frequency value;

identifying a time interval, wherein the time interval includes the first and second time points, and wherein the first dominant frequency value substantially relates to the second dominant frequency value over the time interval; and

outputting the determined attraction point and the identified time interval to a visual display.

17. The method of claim 16, further comprising identifying a frequency interval, wherein the frequency interval includes the first and the second dominant frequency values, and wherein the first dominant frequency value substantially relates to the second dominant frequency value over the frequency interval.

18. The method of claim 16, further comprising:

collecting a signal from a third electrode over a time period; and

generating a third dominant frequency value, wherein the attraction point is defined when the first, second and third dominant frequency values substantially relate to each other.

19. The method of claim 18, further comprising identifying a frequency interval, wherein the frequency interval includes the first, the second and the third dominant frequency values, and wherein the first, second and third dominant frequency values substantially relate to each other over the frequency interval.