Analyte sensor with extended range of detection
First Claim
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1. An analyte sensor, comprising:
- a base configured to be retained at least partially in a subject'"'"'s dermis, wherein the base is solid and impermeable, and having a thickness, an upper surface and an opposite lower surface, a first end, and an opposite second end, the base defining a first chamber disposed therein, the first chamber extending partially through the thickness of the base; and
a first and a second analysis region coupled to the base, the first analysis region comprising a first analyte reagent system and the second analysis region comprising a second analyte reagent system,wherein the first and the second analysis regions have contiguous first and second detection ranges, respectively, for a target analyte, and substantially coextensive ranges of response, the first and second analysis regions configured to exhibit different responses within said coextensive ranges upon exposure to a given concentration of the target analyte and the first analyte reagent system disposed in the first chamber.
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Abstract
Embodiments provide sensors, such as implantable sensors, and methods of producing such sensors. An implantable sensor may include a base, one or more chambers, and one or more sensor reagents. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be at least partially implanted into the dermis of an animal. One or more of the sensor reagents may emit light or exhibit a color change in response to the presence of a target analyte or reaction product thereof. The response may be detected and analyzed by the user or by a reader device to determine the target analyte concentration.
4 Citations
32 Claims
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1. An analyte sensor, comprising:
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a base configured to be retained at least partially in a subject'"'"'s dermis, wherein the base is solid and impermeable, and having a thickness, an upper surface and an opposite lower surface, a first end, and an opposite second end, the base defining a first chamber disposed therein, the first chamber extending partially through the thickness of the base; and a first and a second analysis region coupled to the base, the first analysis region comprising a first analyte reagent system and the second analysis region comprising a second analyte reagent system, wherein the first and the second analysis regions have contiguous first and second detection ranges, respectively, for a target analyte, and substantially coextensive ranges of response, the first and second analysis regions configured to exhibit different responses within said coextensive ranges upon exposure to a given concentration of the target analyte and the first analyte reagent system disposed in the first chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification