Systems and methods for replacing signal artifacts in a glucose sensor data stream
First Claim
1. A method for processing data from an electrochemical glucose sensor, the method comprising:
- applying a voltage to an electrochemical glucose sensor configured to measure a glucose concentration of a biological sample of a host, wherein applying the voltage comprises at least one process selected from the group consisting of switching a voltage applied to the electrochemical glucose sensor, cycling a voltage applied to the electrochemical glucose sensor, and pulsing a voltage applied to the electrochemical glucose sensor;
measuring a signal response of the electrochemical glucose sensor responsive to the at least one process; and
detecting, using a processor, a signal artifact based on the signal response of the electrochemical glucose sensor to the switching, cycling, or pulsing of the applied voltage, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and an interfering species.
2 Assignments
0 Petitions
Accused Products
Abstract
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
681 Citations
84 Claims
-
1. A method for processing data from an electrochemical glucose sensor, the method comprising:
-
applying a voltage to an electrochemical glucose sensor configured to measure a glucose concentration of a biological sample of a host, wherein applying the voltage comprises at least one process selected from the group consisting of switching a voltage applied to the electrochemical glucose sensor, cycling a voltage applied to the electrochemical glucose sensor, and pulsing a voltage applied to the electrochemical glucose sensor; measuring a signal response of the electrochemical glucose sensor responsive to the at least one process; and detecting, using a processor, a signal artifact based on the signal response of the electrochemical glucose sensor to the switching, cycling, or pulsing of the applied voltage, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and an interfering species. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method for processing data from an electrochemical glucose sensor, the method comprising:
-
applying a voltage to an electrochemical glucose sensor configured to measure a glucose concentration of a biological sample of a host; switching the voltage applied to the electrochemical glucose sensor to a different setting; measuring a signal response of the electrochemical glucose sensor responsive to the switching; detecting, using a processor, a signal artifact based on the signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and a biochemical species; generating, using a processor, an estimated glucose value responsive to detection of the signal artifact, wherein the estimated glucose value accounts for the signal artifact; and displaying the estimated glucose value on a user interface. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A method for processing data from an electrochemical glucose sensor, the method comprising:
-
applying a voltage to an electrochemical glucose sensor configured to measure a glucose concentration of a biological sample of a host; switching a voltage applied to the electrochemical glucose sensor to a different setting; measuring a signal response of the electrochemical glucose sensor responsive to the switching; detecting, using a processor, a signal artifact based on a signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and a biochemical species; evaluating, using a processor, a severity of the signal artifact; generating, using a processor, an estimated glucose value responsive to the severity of the signal artifact, wherein the estimated glucose value is generated based at least in part on the severity of the signal artifact; and displaying the estimated glucose value on a user interface. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
-
-
27. A method for processing data from an electrochemical glucose sensor, the method comprising:
-
applying a voltage to an electrochemical glucose sensor configured to measure a glucose concentration of a biological sample of a host; switching a voltage applied to the electrochemical glucose sensor to a different setting; measuring a signal response of the electrochemical glucose sensor responsive to the switching; detecting, using a processor, a signal artifact based on a signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and a biochemical species; evaluating, using a processor, a severity of the signal artifact; and discarding, using a processor, a glucose measurement when the severity of the signal artifact is outside of a predetermined threshold. - View Dependent Claims (28, 29, 30, 31, 32)
-
-
33. A method for processing data from an electrochemical glucose sensor, the method comprising:
-
applying a voltage to an electrochemical glucose sensor configured to measure a glucose concentration of a biological sample of a host; switching the voltage applied to the electrochemical glucose sensor to a different setting; measuring a signal response of the electrochemical glucose sensor responsive to the switching; detecting, using a processor, a signal artifact based on the signal response of the electrochemical glucose sensor to the switching, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and a biochemical species; displaying, using a display, a first screen presenting generated glucose concentration data over a first time period; displaying, using the display, a second screen presenting generated glucose concentration data over a second time period, wherein the second time period is different in length from the first time period; displaying, using the display, a third screen presenting a single generated real-time estimated glucose value; receiving an input from a user to toggle between the first screen, the second screen, and the third screen of the display; and generating an alert responsive to a detection of a hyperglycemic condition or a hypoglycemic condition. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41)
-
-
42. A glucose sensor system, the system comprising:
-
an electrochemical glucose sensor configured to be in contact with a biological fluid to obtain a glucose measurement, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; and sensor electronics comprising a processor for executing computer program code stored in a memory to cause the processor to; apply a voltage to an electrochemical glucose sensor configured to measure glucose concentration of a biological sample of a host, wherein applying a voltage comprises at least one process selected from the group consisting of switching a voltage applied to the electrochemical glucose sensor, cycling a voltage applied to the electrochemical glucose sensor, and pulsing a voltage applied to the electrochemical glucose sensor; measure a signal response of the electrochemical glucose sensor responsive to the at least one process; and detect a signal artifact based on the signal response of the electrochemical glucose sensor to the switching, cycling, or pulsing of the applied voltage, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and an interfering species. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50)
-
-
51. A glucose sensor system, the system comprising:
-
an electrochemical glucose sensor configured to be in contact with a biological fluid to obtain a glucose measurement, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing computer program code stored in a memory to cause the processor to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switch, detect a signal artifact based on the signal response of the electrochemical glucose sensor to the switch, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and biochemical species, and generate an estimated glucose value responsive to detection of the signal artifact, wherein the estimated glucose value accounts for the signal artifact; and a user interface configured to display the estimated glucose value. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59)
-
-
60. A glucose sensor system, the system comprising:
-
an electrochemical glucose sensor configured to be in contact with a biological fluid to obtain a glucose measurement, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing computer program code stored in a memory to cause the processor to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switch, detect a signal artifact based on the signal response of the electrochemical glucose sensor to the switch, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and a biochemical species, evaluate a severity of the signal artifact, and generate an estimated glucose value responsive to severity of the signal artifact, wherein the estimated glucose value is generated based at least in part on the severity of the signal artifact; and a user interface configured to display the estimated glucose value. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67)
-
-
68. A glucose sensor system, the system comprising:
-
an electrochemical glucose sensor configured to be in contact with a biological fluid to obtain a glucose measurement, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; and sensor electronics comprising a processor for executing computer program code stored in a memory to cause the processor to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switch, detect a signal artifact based on the signal response of the electrochemical glucose sensor to the switch, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and biochemical species, evaluate a severity of the signal artifact; and discard a glucose measurement when the severity of the signal artifact is outside of a predetermined threshold. - View Dependent Claims (69, 70, 71, 72, 73)
-
-
74. A glucose sensor system, the system comprising:
-
an electrochemical glucose sensor configured to be in contact with a biological fluid to obtain a glucose measurement, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing computer program code stored in a memory to cause the processor to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switch, and detect a signal artifact based on the signal response of the electrochemical glucose sensor to the switch, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and biochemical species; and a user interface configured to; display a first screen presenting generated glucose concentration data over a first time period, display a second screen presenting generated glucose concentration data over a second time period, wherein the second time period is different in length from the first time period, display a third screen presenting a single generated real-time estimated glucose value; allow a user to toggle between the first screen, the second screen, and the third screen; and generate an alert responsive to a detection of a hyperglycemic condition or a hypoglycemic condition. - View Dependent Claims (75, 76, 77, 78, 79, 80, 81, 82)
-
-
83. A glucose sensor system, the system comprising:
-
an electrochemical glucose sensor configured to be in contact with blood to obtain a glucose measurement, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; sensor electronics comprising a processor for executing computer program code stored in a memory to cause the processor to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switch, wherein the signal response is a voltage, detect a signal artifact based on the signal response of the electrochemical glucose sensor to the switch, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and biochemical species, evaluate a severity of the signal artifact, and generate a single generated real-time estimated glucose value responsive to detection of the signal artifact, wherein the single generated real-time estimated glucose value is generated based at least in part on the severity of the signal artifact; and a user interface configured to; display a first screen presenting generated glucose concentration data over a first time period, display a second screen presenting generated glucose concentration data over a second time period, wherein the second time period is different in length from the first time period, display a third screen presenting a single generated real-time estimated glucose value; allow a user to toggle between the first screen, the second screen, and the third screen; and generate an alert responsive to detection of a hyperglycemic condition or a hypoglycemic condition.
-
-
84. A glucose sensor system, the system comprising:
-
an electrochemical glucose sensor configured to be in contact with blood to obtain a glucose measurement, wherein the electrochemical glucose sensor comprises a first electrode, a second electrode, and an enzyme-containing film; and sensor electronics comprising a processor for executing computer program code stored in a memory to cause the processor to; apply a voltage to the electrochemical glucose sensor at a first setting, switch the voltage applied to the electrochemical sensor to a different setting, measure a signal response of the electrochemical glucose sensor responsive to the switch, wherein the signal response is a voltage, detect a signal artifact based on the signal response of the electrochemical glucose sensor to the switch, wherein the signal artifact is associated with at least one condition selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface area, and biochemical species, evaluate a severity of the signal artifact, discard a glucose measurement when the severity of the signal artifact is outside of a predetermined threshold, generate, when the severity of the signal artifact is within a predetermined threshold, a single generated real-time estimated glucose value responsive to detection of the signal artifact, wherein the single generated real-time estimated glucose value is generated based at least in part on the severity of the signal artifact; and a user interface configured to; display a first screen presenting generated glucose concentration data over a first time period, display a second screen presenting generated glucose concentration data over a second time period, wherein the second time period is different in length from the first time period, display a third screen presenting a single generated real-time estimated glucose value; allow a user to toggle between the first screen, the second screen, and the third screen; and generate an alert responsive to detection of a hyperglycemic condition or a hypoglycemic condition.
-
Specification