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Injection-molded dosage form

  • US 9,649,278 B2
  • Filed: 10/09/2012
  • Issued: 05/16/2017
  • Est. Priority Date: 10/12/2011
  • Status: Active Grant
First Claim
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1. An injection-molded shell of a dosage form produced bya) providing a composition comprising i) from 30 to 80 weight percent of ethylcellulose having a viscosity of up to 400 mPa·

  • s, measured as a 5 weight percent solution at 25°

    C. in a mixture of 80 volume percent toluene and 20 volume percent ethanol, ii) from 10 to 50 weight percent of a cellulose ether having a viscosity from 1.2 to 200 mPa·

    s, measured as a 2 weight-% aqueous solution at 20°

    C. according to ASTM D2363-79, and being selected from the group consisting of methylcellulose, hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, ethylhydroxyethyl cellulose, hydroxypropyl cellulose, cross-linked carboxymethylcellulose, non-crosslinked carboxymethylcellulose, and combinations of two or more of these cellulose ethers, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, andb) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.

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