Microneedle transdermal delivery device
First Claim
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1. A transdermal device comprising:
- a first roller and a second roller; and
a plurality of microneedles carried on a belt that is wrapped at least partially around the first roller and at least partially around the second roller such that movement of the first roller over skin of a patient causes the first roller to rotate and bring the microneedles into contact with the skin of the patient under pressure from the first roller;
wherein the second roller is positioned so as to follow the first roller as it is moved over the skin of the patient, to apply pressure to the belt that has unwrapped from the first roller and to rotate and take up the belt; and
wherein the microneedles are carried on a patch that is affixed to the belt; and
further comprising a support frame, the support frame having a glide track which extends along a length of the frame, wherein the first and second rollers are rotatably mounted in the glide track and are capable of sliding along the glide track.
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Abstract
A drug delivery device that delivers pharmacologically active substances transdermally using microneedles arranged on a belt mounted rotatably about a plurality of rollers, the microneedles having an associated drug reservoir mounted on the belt which is compressed when the needles and belt are brought into contact with the skin.
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Citations
12 Claims
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1. A transdermal device comprising:
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a first roller and a second roller; and a plurality of microneedles carried on a belt that is wrapped at least partially around the first roller and at least partially around the second roller such that movement of the first roller over skin of a patient causes the first roller to rotate and bring the microneedles into contact with the skin of the patient under pressure from the first roller; wherein the second roller is positioned so as to follow the first roller as it is moved over the skin of the patient, to apply pressure to the belt that has unwrapped from the first roller and to rotate and take up the belt; and wherein the microneedles are carried on a patch that is affixed to the belt; and further comprising a support frame, the support frame having a glide track which extends along a length of the frame, wherein the first and second rollers are rotatably mounted in the glide track and are capable of sliding along the glide track. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A transdermal device comprising
a first roller and a second roller; -
a plurality of microneedles carried on a belt that is wrapped at least partially around the first roller and at least partially around the second roller such that movement of the first roller over skin of a patient causes the first roller to rotate and bring the microneedles into contact with the skin of the patient under pressure from the first roller; wherein the second roller is positioned so as to follow the first roller as it is moved over the skin of the patient, to apply pressure to the belt that has unwrapped from the first roller and to rotate and take up the belt; and wherein the microneedles are carried on a patch that is affixed to the belt; and one or more compressible reservoirs disposed on the patch that is affixed to the belt such that rotation of the first roller when it moves over the skin of the patient brings the reservoirs into contact with the skin of the patient and compresses the reservoirs against the skin; and
wherein each of the microneedles has a bore that is in fluid communication with a reservoir such that, when the reservoir is compressed, fluid is forced out of the reservoir and through the bore in the microneedle towards the skin. - View Dependent Claims (10)
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11. A transdermal device comprising:
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a roller; a plurality of microneedles supported by the roller such that movement of the roller over skin of a patient causes the roller to rotate and bring the microneedles into contact with the skin; and one or more compressible reservoirs disposed on an outer surface of the roller such that rotation of the roller when it moves over the skin brings the reservoirs into contact with the skin and compresses the reservoirs against the skin; wherein each of the microneedles has a bore that is in fluid communication with one of the reservoirs such that, when the reservoir is compressed, fluid is forced out of the reservoir and through the bore in the microneedle towards the skin; and wherein the relative position of each microneedle and the reservoir with which it is in fluid communication is such that on rotation of the roller the microneedle comes into contact with the skin before the reservoir comes into contact with the skin.
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12. A transdermal device comprising
a first roller and a second roller; -
a plurality of microneedles carried on a belt that is wrapped at least partially around the first roller and at least partially around the second roller such that movement of the first roller over skin of a patient causes the first roller to rotate and bring the microneedles into contact with the skin of the patient under pressure from the first roller; wherein the second roller is positioned so as to follow the first roller as it is moved over the skin of the patient, to apply pressure to the belt that has unwrapped from the first roller and to rotate and take up the belt; and one or more compressible reservoirs disposed on a patch that is affixed to the belt such that rotation of the first roller when it moves over the skin of the patient brings the reservoirs into contact with the skin of the patient and compresses the reservoirs against the skin; and
wherein each of the microneedles has a bore that is in fluid communication with a reservoir such that, when pressure on the reservoir is reduced, fluid is withdrawn from the skin through the bore in the microneedle.
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Specification