Closed loop optimization of control parameters during cardiac pacing

• US 9,649,497 B2
• Filed: 03/07/2016
• Issued: 05/16/2017
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ghosh, Subham
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US15/062,945
• Publication Number:
  US 20160184590A1
• Time in Patent Office: 435 Days
• Field of Search: 607 17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A system and method control a pacing parameter in a closed-loop manner by determining a value of an EGM-based index corresponding an optimal electrical activation condition of a patient'"'"'s heart and adjusting a pacing therapy to maintain the EGM-based index value. The closed loop control method performed by the system may establish a relationship between an EGM-based index and multiple settings of a pacing control parameter. Values of the EGM-based index are stored with corresponding setting shifts relative to a previously established optimal setting. A processor of an implantable medical device monitors the EGM-based index during cardiac pacing. Responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, the processor determines an adjustment of the control parameter from the stored index values and corresponding setting shifts.

Claims

1. A medical device system for optimizing a pacing control parameter, comprising:

a plurality of cardiac electrodes;

a cardiac signal generator coupled to the electrodes for delivering cardiac pacing pulses;

a sensing module coupled to the cardiac electrodes for acquiring an EGM signal; and

a processor configured to determine a value of an EGM-based index corresponding to an optimal electrical activation condition of a patient'"'"'s heart and adjust a pacing therapy control parameter to maintain the EGM-based index value corresponding to the optimal electrical activation condition during delivery of the cardiac pacing pulses.

2. The system of claim 1, wherein:

the cardiac signal generator is configured to deliver cardiac pacing according to each of a plurality of settings of a pacing control parameter, the plurality of settings comprising a previously established optimal setting and at least one non-optimal setting different than the optimal setting by a setting shift;

the processor further configured to;

establish a relationship between an EGM-based index and the plurality of settings by determining the EGM-based index from the EGM signal acquired during cardiac pacing at each of the plurality of settings and storing values of the determined index with corresponding setting shifts of each of the plurality of settings relative to the optimal setting;

monitor the EGM-based index during cardiac pacing; and

responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, determine an adjustment of the control parameter from the stored index values and corresponding setting shifts, and adjust the control parameter by the determined adjustment.

3. The system of claim 2, further comprising a plurality of surface electrodes adapted to be positioned on a patient'"'"'s body and a processor for establishing the optimal setting by computing an index of ventricular dyssynchrony for each of a plurality of pacing control parameter settings in response to surface potential signals sensed from the plurality of surface electrodes.

4. The system of claim 2, wherein the plurality of electrodes comprises a left ventricular electrode and a right ventricular coil electrode and acquiring the EGM signal comprises selecting a sensing vector comprising the left ventricular electrode and the right ventricular coil electrode.

5. The system of claim 2, wherein the processor is further configured to determine a magnitude and polarity of a setting shift corresponding to the detected EGM-based index corresponding to a non-optimal setting;

and

determine the adjustment as the magnitude and a polarity opposite to the setting shift corresponding to the detected EGM-based index.

6. The system of claim 2, wherein the optimal pacing control parameter comprises an optimal atrio-ventricular (AV) delay used by the signal generator to delivery cardiac resynchronization therapy.

7. The system of claim 2, wherein the processor is further configured to establish the relationship between the EGM-based index and a plurality of settings of the control parameter for each of a plurality of different heart rhythm states.

8. The system of claim 2, wherein the processor is further configured to establish the relationship between the EGM-based index and a plurality of settings of the control parameter for each of a plurality of pacing electrode vectors.

9. The system of claim 2, further comprising a memory for storing the relationship as a look-up table of determined EGM-based index values and associated setting shifts, the memory accessed by the processor for determining the adjustment.

10. The system of claim 2, wherein the processor is further configured to:

detect an unchanged value of the EGM-based index in response to adjustment of the control parameter; and

switch a pacing mode in response to the unchanged value.

11. The system of claim 1, wherein determining the EGM-based index comprises detecting a maximum peak amplitude of the EGM signal following a pacing pulse.

12. The system of claim 1, wherein determining the EGM-based index comprises determining a time interval between a maximum peak amplitude and a minimum peak amplitude of the EGM signal following a pacing pulse.

13. A medical device system for optimizing a pacing control parameter, comprising:

a plurality of cardiac electrodes;

a cardiac signal generator coupled to the electrodes for delivering cardiac pacing pulses;

a sensing module coupled to the cardiac electrodes for acquiring an EGM signal;

a processor configured to determine a value of an EGM-based index corresponding to an optimal electrical activation condition of a patient'"'"'s heart and adjust a pacing therapy control parameter to maintain the EGM-based index value corresponding to the optimal electrical activation condition during delivery of the cardiac pacing pulses;

the cardiac signal generator is configured to deliver cardiac pacing according to each of a plurality of settings of a pacing control parameter, the plurality of settings comprising a previously established optimal setting and at least one non-optimal setting different than the optimal setting by a setting shift;

the processor further configured to;

establish a relationship between an EGM-based index and the plurality of settings by determining the EGM-based index from the EGM signal acquired during cardiac pacing at each of the plurality of settings and storing values of the determined index with corresponding setting shifts of each of the plurality of settings relative to the optimal setting;

monitor the EGM-based index during cardiac pacing; and

responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, determine an adjustment of the control parameter from the stored index values and corresponding setting shifts, and adjust the control parameter by the determined adjustment.

14. A medical device system for optimizing a pacing control parameter, comprising:

a plurality of cardiac electrodes;

a cardiac signal generator coupled to the electrodes for delivering cardiac pacing pulses;

a sensing module coupled to the cardiac electrodes for acquiring an EGM signal; and

a processor configured to determine a value of an EGM-based index corresponding to an optimal electrical activation condition of a patient'"'"'s heart and adjust a pacing therapy control parameter to maintain the EGM-based index value corresponding to the optimal electrical activation condition during delivery of the cardiac pacing pulses, wherein determining the EGM-based index comprises determining a time interval between a maximum peak amplitude and a minimum peak amplitude of the EGM signal following a pacing pulse.