Oxygen sensors

• US 9,650,566 B2
• Filed: 07/12/2016
• Issued: 05/16/2017
• Est. Priority Date: 03/14/2013
• Status: Active Grant

• Current Assignee: Profusa, Inc.
• Original Assignee: Profusa, Inc.
• Inventors: Gamsey, Soya, Helton, Kristen, McMillan, William, Wisniewski, Natalie
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): SAMALA, JAGADISHWAR RAO
• Application Number:
  US15/208,027
• Publication Number:
  US 20160376501A1
• Time in Patent Office: 308 Days
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61K 49/0036 Porphyrins used in photodynamic therapy A61K41/0071 or A61K41/0076; used as targeting group or modifying agent for targeting a therapeutic compound A61K47/546
• CPC Class Codes: A61K 49/0054 Macromolecular compounds, i.e. oligomers, polymers, dendrimers
• CPC Class Codes: A61K 49/0073 semi-solid, gel, hydrogel, ointment
• CPC Class Codes: C07F 15/0066 without a metal-carbon linkage
• CPC Class Codes: C09K 11/06 containing organic luminescent materials
• CPC Class Codes: C09K 2211/185 of the platinum group, i.e. Os, Ir, Pt, Ru, Rh or Pd
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: G01N 2333/904 acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

Claims

1. A compound of Formula I:

2. The compound of claim 1 wherein R² and R³ are fused to form an aryl.

3. The compound of claim 1 wherein R² and R³ are fused to form a heteroaryl.

4. The compound of claim 1 wherein R² and R³ are fused to form a cycloalkenyl.

5. The compound of claim 1 wherein and R₁ and R₇ are both C(O)X—

(CH₂)_n—

YC(O)C(R₄)CH₂.

6. The compound of claim 1 wherein M is Pd.

7. The compound of claim 1 wherein R₂ and R₃ are fused to form a benzene ring, and R₁ and R₇ are both C(O)NH(CH₂)₂OC(O)C(CH₃)CH₂.

8. The compound of claim 1, wherein the compound is:

9. The compound of claim 1 wherein the compound has an absorption maximum between 500 nm and 900 nm and an emission maximum between 600 nm and 1000 nm.

10. The compound of claim 9 has an absorption maximum between 500 nm and 800 nm.

11. The compound of claim 9 has an emission maximum between 650 nm and 900 nm.