Modalities for the treatment of degenerative diseases of the retina
First Claim
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1. A method for treating a retinal disease or condition in a human subject comprisingtransplanting, into the eye of the human subject, human RPE cells obtained by in vitro differentiation of human pluripotent cells that express Oct-4, alkaline phosphatase, SSEA-3, SSEA-4, TRA-I-60, and TRA-I-8I, wherein said RPE cells are disposed on a substrate or matrix, and have a normal karyotype, thereby treating the disease or condition as determined by functional testing.
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Abstract
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.
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12 Claims
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1. A method for treating a retinal disease or condition in a human subject comprising
transplanting, into the eye of the human subject, human RPE cells obtained by in vitro differentiation of human pluripotent cells that express Oct-4, alkaline phosphatase, SSEA-3, SSEA-4, TRA-I-60, and TRA-I-8I, wherein said RPE cells are disposed on a substrate or matrix, and have a normal karyotype, thereby treating the disease or condition as determined by functional testing.
Specification