Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
First Claim
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1. A device for voltage sensing of analytes, the device comprising:
- a plurality of fluidic channels, each defined by a trench in a substrate, each fluidic channel having at least one pair of sensing electrodes defining a detection zone disposed in each of the channels for sensing voltage therein, each detection zone comprising a first and a second sensing electrode disposed at two discrete laterally offset locations along a length of each fluidic channel, the sensing electrodes being connected to a voltmeter for measuring a voltage sensed by the sensing electrodes, and the pair of sensing electrodes not being connected to a voltage source;
a first common channel disposed at the first ends of the plurality of fluidic channels;
a second common channel disposed at the second ends of the plurality of fluidic channels; and
at least one electromotive electrode disposed in each of the first and second common channels for applying a potential along the fluidic channels,wherein the fluidic channels each comprise a nanochannel or a microchannel.
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Abstract
Devices for detecting an analyte are provided. Devices for voltage sensing of analytes may comprise a plurality of fluidic channels defined in a substrate, each channel having a pair of sensing electrodes disposed in or adjacent to the fluidic channel and defining a detection volume for sensing voltage therein. At least one pair of electromotive electrodes for applying potential along at least one fluidic channel is provided as well.
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Citations
16 Claims
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1. A device for voltage sensing of analytes, the device comprising:
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a plurality of fluidic channels, each defined by a trench in a substrate, each fluidic channel having at least one pair of sensing electrodes defining a detection zone disposed in each of the channels for sensing voltage therein, each detection zone comprising a first and a second sensing electrode disposed at two discrete laterally offset locations along a length of each fluidic channel, the sensing electrodes being connected to a voltmeter for measuring a voltage sensed by the sensing electrodes, and the pair of sensing electrodes not being connected to a voltage source;
a first common channel disposed at the first ends of the plurality of fluidic channels;
a second common channel disposed at the second ends of the plurality of fluidic channels; and
at least one electromotive electrode disposed in each of the first and second common channels for applying a potential along the fluidic channels,wherein the fluidic channels each comprise a nanochannel or a microchannel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification