Short-wave infrared super-continuum lasers for detecting counterfeit or illicit drugs and pharmaceutical process control

• US 9,651,533 B2
• Filed: 10/06/2015
• Issued: 05/16/2017
• Est. Priority Date: 12/31/2012
• Status: Active Grant

• Current Assignee: Omni Medsci, Inc.
• Original Assignee: Omni Medsci, Inc.
• Inventors: Islam, Mohammed N.
• Primary Examiner(s): Porta, David
• Assistant Examiner(s): FEIN, ABRA S
• Application Number:
  US14/875,709
• Publication Number:
  US 20160047787A1
• Time in Patent Office: 588 Days
• Field of Search: 2503384
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 2562/146 for optical coupling
• CPC Class Codes: A61B 2576/02 specially adapted for a particular organ or body part
• CPC Class Codes: A61B 5/0013 Medical image data A61B1/00011, A61B6/56, A61B8/56 take precedence
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/0088 for oral or dental tissue
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/4547 Evaluating teeth
• CPC Class Codes: A61B 5/6801 specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/7405 using sound
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: G01J 2003/104 Monochromatic plural sources
• CPC Class Codes: G01J 2003/1208 Prism and grating
• CPC Class Codes: G01J 2003/2826 Multispectral imaging, e.g. filter imaging
• CPC Class Codes: G01J 3/0218 : using optical fibers
• CPC Class Codes: G01J 3/108 : for measurement in the infrared range
• CPC Class Codes: G01J 3/14 : using refracting elements, e.g. prisms G01J3/18, G01J3/26 take precedence prisms per se G02B5/04
• CPC Class Codes: G01J 3/1838 : Holographic gratings
• CPC Class Codes: G01J 3/28 : Investigating the spectrum using colour filters G01J3/51
• CPC Class Codes: G01J 3/2823 : Imaging spectrometer
• CPC Class Codes: G01J 3/42 : Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01J 3/453 : by correlation of the amplitudes
• CPC Class Codes: G01M 3/38 : by using light G01M3/02 takes precedence
• CPC Class Codes: G01N 2021/3595 : using FTIR
• CPC Class Codes: G01N 2021/399 : Diode laser
• CPC Class Codes: G01N 21/35 : using infrared light G01N21/39 takes precedence
• CPC Class Codes: G01N 21/3563 : for analysing solids; Preparation of samples therefor
• CPC Class Codes: G01N 21/359 : using near infrared light
• CPC Class Codes: G01N 21/39 : using tunable lasers
• CPC Class Codes: G01N 21/85 : Investigating moving fluids or granular solids
• CPC Class Codes: G01N 21/88 : Investigating the presence of flaws or contamination
• CPC Class Codes: G01N 21/9508 : Capsules; Tablets
• CPC Class Codes: G01N 2201/0221 : Portable; cableless; compact; hand-held
• CPC Class Codes: G01N 2201/061 : Sources
• CPC Class Codes: G01N 2201/06113 : Coherent sources; lasers
• CPC Class Codes: G01N 2201/062 : LED's
• CPC Class Codes: G01N 2201/08 : Optical fibres; light guides
• CPC Class Codes: G01N 2201/12 : Circuits of general importance; Signal processing
• CPC Class Codes: G01N 2201/129 : Using chemometrical methods
• CPC Class Codes: G01N 33/02 : Food
• CPC Class Codes: G01N 33/025 : Fruits or vegetables
• CPC Class Codes: G01N 33/15 : Medicinal preparations ; Physical properties thereof, e.g. dissolubility drug screening with animal cells G01N33/5008
• CPC Class Codes: G01N 33/442 : Resins, plastics
• CPC Class Codes: G01N 33/49 : Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G16H 40/67 : for remote operation
• CPC Class Codes: G16Z 99/00 : Subject matter not provided for in other main groups of this subclass
• CPC Class Codes: H01S 3/0092 : Nonlinear frequency conversion, e.g. second harmonic generation [SHG] or sum- or difference-frequency generation outside the laser cavity nonlinear frequency conversion per se G02F1/35
• CPC Class Codes: H01S 3/06758 : Tandem amplifiers
• CPC Class Codes: H01S 3/302 : in an optical fibre
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A measurement system includes a wearable measurement device for measuring one or more physiological parameters, including a light source comprising a plurality of light emitting diodes (LEDs) configured to generate an output optical beam with a near-infrared wavelength between 700 nanometers and 2500 nanometers. The light source is configured to increase signal-to-noise ratio by increasing a light intensity and pulse rate of the LEDs. The system includes a plurality of lenses configured to receive the output optical beam and to deliver an analysis output beam to a sample. The wearable measurement device includes a receiver configured to process the analysis output beam reflected or transmitted from the sample and to generate an output signal that may be transmitted to a remote device configured to process the received output status to generate processed data and to store the processed data.

Claims

1. A measurement system comprising:

a light source configured to generate an output optical beam, comprising;

one or more semiconductor sources configured to generate an input beam;

one or more optical amplifiers configured to receive at least a portion of the input beam and to output an intermediate beam from at least one of the one or more optical amplifiers; and

one or more optical fibers configured to receive at least a portion of the intermediate beam and to communicate at least part of the portion of the intermediate beam to a distal end of the one or more optical fibers to form a first optical beam;

a nonlinear element configured to receive at least a portion of the first optical beam and to broaden a spectrum associated with the at least a portion of the first optical beam to at least 10 nm through a nonlinear effect in the nonlinear element to form the output optical beam with an output beam broadened spectrum; and

wherein at least a portion of the output beam broadened spectrum comprises a near-infrared wavelength between approximately 700 nm and approximately 2500 nm, and wherein at least a portion of the one or more fibers is a fused silica fiber with a core diameter less than approximately 400 microns;

a measurement apparatus configured to receive a received portion of the output optical beam and to deliver to a sample an analysis output beam, which is a delivered portion of the output optical beam and wherein the delivered portion of the output optical beam is a spatially coherent beam;

a receiver configured to receive and process at least a portion of the analysis output beam reflected or transmitted from the sample having a bandwidth of at least 10 nanometers and to generate an output signal; and

a personal device comprising a wireless receiver, a wireless transmitter, a display, a microphone, a speaker, one or more buttons or knobs, a microprocessor and a touch screen, the personal device configured to receive and process at least a portion of the output signal, wherein the personal device is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link.

2. The system of claim 1, wherein the personal device is selected from the group consisting of a smart phone, a tablet, a personal data assistant, a computer, and a microprocessor-based device.

3. The system of claim 1, wherein the output signal comprises one or more physiological parameters.

4. The system of claim 1, further comprising a remote device configured to receive over the wireless transmission link a received output status comprising the at least a portion of the processed output signal, to buffer the received output status, to process the received output status to generate processed data and to store the processed data.

5. A measurement system comprising:

a light source comprising a plurality of semiconductor sources that are light emitting diodes, the light emitting diodes configured to generate an output optical beam with one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers,

the light source configured to increase signal-to-noise ratio by increasing a light intensity from at least one of the plurality of semiconductor sources and by increasing a pulse rate of at least one of the plurality of semiconductor sources;

an apparatus comprising a plurality of lenses configured to receive a portion of the output optical beam and to deliver an analysis output beam to a sample

a receiver configured to receive and process at least a portion of the analysis output beam reflected or transmitted from the sample and to generate an output signal, wherein the receiver is configured to be synchronized to the light source;

a personal device comprising a wireless receiver, a wireless transmitter, a display, a microphone, a speaker, one or more buttons or knobs, a microprocessor and a touch screen, the personal device configured to receive and process at least a portion of the output signal, wherein the personal device is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link; and

a remote device configured to receive over the wireless transmission link an output status comprising the at least a portion of the processed output signal, to process the received output status to generate processed data and to store the processed data.

6. The system of claim 5, wherein at least one of the light emitting diodes emits light with a bandwidth between 20 nanometers to 40 nanometers.

7. The system of claim 5, wherein the remote device is further configured to transmit at least a portion of the processed data to one or more other locations, wherein the one or more other locations is selected from the group consisting of the personal device, a doctor, a healthcare provider, a cloud-based server and one or more designated recipients, and wherein the remote device is capable of transmitting information related to a time and a position associated with the at least a portion of the processed data.

8. The system of claim 5, wherein the receiver is located a first distance from a first one of the plurality of light emitting diodes and a different, second distance from a second one of the plurality of light emitting diodes such that the receiver receives a first signal from the first light emitting diode and a second signal from the second light emitting diode.

10. The system of claim 5, wherein the output signal comprises one or more physiological parameters, and the remote device is capable of storing a history of at least a portion of the one or more physiological parameters over a specified period of time.

11. The system of claim 5, wherein the receiver further comprises one or more filters in front of one of more detectors to select a fraction of the one or more optical wavelengths.

12. The system of claim 5, wherein the output optical beam comprises a plurality of optical wavelengths, and the output signal is generated in part by comparing signals at different optical wavelengths.

9. The system of claim89, wherein the output signal is generated in part by comparing the first and second signals.

13. A measurement system comprising:

a wearable measurement device for measuring one or more physiological parameters, including a light source comprising a plurality of semiconductor sources that are light emitting diodes, the light emitting diodes configured to generate an output optical beam with one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers,

the light source configured to increase signal-to-noise ratio by increasing a light intensity from at least one of the plurality of semiconductor sources and by increasing a pulse rate of at least one of the plurality of semiconductor sources;

the wearable measurement device comprising a plurality of lenses configured to receive a portion of the output optical beam and to deliver an analysis output beam to a sample;

the wearable measurement device further comprising a receiver configured to receive and process at least a portion of the analysis output beam reflected or transmitted from the sample and to generate an output signal, wherein the wearable measurement device receiver is configured to be synchronized to pulses of the light source;

a personal device comprising a wireless receiver, a wireless transmitter, a display, a microphone, a speaker, one or more buttons or knobs, a microprocessor and a touch screen, the personal device configured to receive and process at least a portion of the output signal, wherein the personal device is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link; and

a remote device configured to receive over the wireless transmission link an output status comprising the at least a portion of the processed output signal, to process the received output status to generate processed data and to store the processed data, and wherein the remote device is capable of storing a history of at least a portion of the received output status over a specified period of time.

14. The system of claim 13, wherein at least one of the light emitting diodes emits light with a bandwidth between approximately 20 nanometers to approximately 40 nanometers.

15. The system of claim 13, wherein the remote device is further configured to transmit at least a portion of the processed data to one or more other locations, wherein the one or more other locations is selected from the group consisting of the personal device, a doctor, a healthcare provider, a cloud-based server and one or more designated recipients, and wherein the remote device is capable of transmitting information related to a time and a position associated with the at least a portion of the processed data.

16. The system of claim 13, wherein the receiver is located a first distance from a first one of the plurality of light emitting diodes and a different, second distance from a second one of the plurality of light emitting diodes such that the receiver receives a first signal from the first light emitting diode and a second signal from the second light emitting diode.

17. The system of claim 16, wherein the output signal is generated in part by comparing the first and second signals.

18. The system of claim 13, wherein the receiver further comprises one or more filters in front of one of more detectors to select a fraction of the one or more optical wavelengths.