Method and kit for the detection of hepatitis-specific antibodies
First Claim
1. A kit for the detection of hepatitis virus-specific antibodies in a subject comprising:
- a container for retaining a tissue sample, wherein said container comprises a medium, said medium comprising a) one or more activators of (i) lymphocytes activated by said hepatitis virus, (ii) memory cells specific for said hepatitis virus, (iii) antibodies against said hepatitis virus, or (iv) a combination thereof, and b) an anti-CD19 antibody against a B-lymphocyte membrane domain.
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Abstract
The present invention relates to an improved method for detecting antibodies to a hepatitis virus in a tissue sample from individuals, which can reliably detect antibodies in recently infected individuals and which provides much lower false positive results in individuals that have cleared their hepatitis infections. More particularly, the present invention relates to an improved method and kit which utilizes an activator of (i) hepatitis virus-primed lymphocytes, (ii) memory cells specific for said hepatitis virus, (iii) hepatitis virus-specific antibody production, or (iv) a combination thereof in a tissue sample to stimulate the production of antibodies from newly primed B cells, if present.
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Citations
18 Claims
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1. A kit for the detection of hepatitis virus-specific antibodies in a subject comprising:
- a container for retaining a tissue sample, wherein said container comprises a medium, said medium comprising a) one or more activators of (i) lymphocytes activated by said hepatitis virus, (ii) memory cells specific for said hepatitis virus, (iii) antibodies against said hepatitis virus, or (iv) a combination thereof, and b) an anti-CD19 antibody against a B-lymphocyte membrane domain.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
Specification