Polymer based hydrogel

• US 9,655,990 B2
• Filed: 04/08/2014
• Issued: 05/23/2017
• Est. Priority Date: 04/08/2013
• Status: Active Grant

• Current Assignee: Yeditepe Üniversitesi
• Original Assignee: Yeditepe Üniversitesi
• Inventors: Demirci, Selami, Sahin, Fikrettin, Dogan, Aysegul
• Primary Examiner(s): Solola, Taofiq A
• Application Number:
  US14/783,081
• Publication Number:
  US 20160051724A1
• Time in Patent Office: 1,141 Days
• Field of Search: 514784
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/84 obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
• CPC Class Codes: A61K 8/90 Block copolymers A61K8/89 takes precedence
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/10 containing or releasing inorganic materials
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 26/0004 containing inorganic materials
• CPC Class Codes: A61L 26/0019 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 26/0066 Medicaments; Biocides
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations
• CPC Class Codes: C08K 2003/387 : Borates
• CPC Class Codes: C08K 3/38 : Boron-containing compounds
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides

Abstract

The present invention relates to an anti-aging antimicrobial wound healing polymer based hydrogel. In the study of the present invention, a wound healing gel formulation is developed by combining poloxamer polymers and boron component at adequate concentrations in a carbopol based gel. The said gel exhibits fast action on the damaged area and prevents scar formation.

Claims

1. An anti-aging, wound-healing and antimicrobial hydrogel, which is comprising:

3% boron compound, 4% poloxamer and 1% gel;

wherein the boron compound and the poloxamer are added to the gel that is prepared as a carrier, wherein the boron compound is selected from a group consisting of sodium pentaborate pentahydrate, boric acid, alkaline and alkaline earth metal borates and all hydrate forms of these borates, ammonium borates, and boric acid esters.

2. The hydrogel according to claim 1, wherein the gel comprises carbopol.

3. The hydrogel according to claim 1, wherein the boron derivative is a sodium pentaborate pentahydrate.

4. The hydrogel according to claim 1, wherein a mixture of the gel, the boron compound and the poloxamer are stored at 4°

C. for 16-24 hours before it can be used.

5. The hydrogel according to claim 1, wherein the boron compound is a boric acid.

6. The hydrogel according to claim 1, wherein the boron compound is alkaline metal borates.

7. The hydrogel according to claim 1, wherein the boron compound is alkaline earth metal borates.

8. The hydrogel according to claim 1, wherein the form of the hydrogel is selected from a group consisting of lotion, cream, emulsion, spray, foam, gelatin, paste, powder, plaster, skin plate, and wound dressing textile product.