Coated vaso-occlusive device for treatment of aneurysms
First Claim
1. A method of treating an aneurysm in a patient, comprising feeding a vaso-occlusive device and genipin or a crosslinking genipin derivative into a fundus of the aneurysm using a catheter.
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Accused Products
Abstract
A method is described herein for the treatment of intracranial aneurysms. The method comprises inserting into an aneurysm an embolism coil coated with a polymeric coating comprising a genipin, such as genipin or a derivative thereof, thereby increasing the stability of clots within the aneurysm. According to one example, the coating is a poly(L-lactide-co-glycolide) (PLGA) is used to release genipin to crosslink fibrin clots thereby creating more stable occlusions. Increased clotting can improve segregation of the weakened portion of the blood vessel from the rest of the vasculature and reduce the risk of recurrence.
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Citations
37 Claims
- 1. A method of treating an aneurysm in a patient, comprising feeding a vaso-occlusive device and genipin or a crosslinking genipin derivative into a fundus of the aneurysm using a catheter.
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20. A vaso-occluding catheter device comprising a sheath and at least a first filament comprising a core substrate within the sheath, wherein either:
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the first filament comprises a controlled release coating layer on the core substrate comprising genipin or a crosslinking genipin derivative, or the device comprises within the sheath a controlled-release second filament comprising a bioerodible polymer comprising genipin or a crosslinking genipin derivative. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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Specification