Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
First Claim
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1. A system comprising:
- a substrate sized for placement on an external surface of a vertebrate subject, the substrate including an adhesive material;
one or more cooling elements attached to the substrate and configured to be applied to the external surface of the vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject;
one or more sensors configured to sense a plasma level of one or more of a metabolic analyte, a sugar, a lipoprotein, or a fatty acid in the vertebrate subject;
a programmable controller operably coupled to the one or more cooling elements and to the one or more sensors, the programmable controller configured to receive information regarding the plasma level of the one or more of the metabolic analyte, the sugar, the lipoprotein, or the fatty acid in the vertebrate subject from the one or more sensors and configured to provide instructions to the one or more cooling elements in response to the information regarding the plasma level of the one or more of the metabolic analyte, the sugar, the lipoprotein, or the fatty acid in the vertebrate subject; and
programming designed to induce weight loss.
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Abstract
Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.
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Citations
46 Claims
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1. A system comprising:
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a substrate sized for placement on an external surface of a vertebrate subject, the substrate including an adhesive material; one or more cooling elements attached to the substrate and configured to be applied to the external surface of the vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject; one or more sensors configured to sense a plasma level of one or more of a metabolic analyte, a sugar, a lipoprotein, or a fatty acid in the vertebrate subject; a programmable controller operably coupled to the one or more cooling elements and to the one or more sensors, the programmable controller configured to receive information regarding the plasma level of the one or more of the metabolic analyte, the sugar, the lipoprotein, or the fatty acid in the vertebrate subject from the one or more sensors and configured to provide instructions to the one or more cooling elements in response to the information regarding the plasma level of the one or more of the metabolic analyte, the sugar, the lipoprotein, or the fatty acid in the vertebrate subject; and programming designed to induce weight loss. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A system comprising:
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a non-transitory signal-bearing medium configured for use in a computing device including, one or more instructions for applying cooling to one or more tissues of a vertebrate subject with one or more cooling elements of a treatment device, wherein the one or more cooling elements are configured to induce non-shivering thermogenesis in brown adipose tissue of the vertebrate subject; one or more instructions for processing information regarding at least one of a number of calories ingested by the vertebrate subject or a type and quantity of food ingested by the vertebrate subject; and one or more instructions for controlling the one or more cooling elements with a programmable controller operably coupled to the one or more cooling elements, the programmable controller configured to provide instructions to the one or more cooling elements in response to the information regarding the at least one of the number of calories ingested by the vertebrate subject or the type and the quantity of food ingested by the vertebrate subject. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A system for modulating activity of brown
adipose tissue, comprising: -
a cooling device including a substrate sized for placement on an external surface of a vertebrate subject, the substrate including an adhesive material; one or more cooling elements attached to the substrate and configured for contact with the external surface of the vertebrate subject; a programmable controller operably coupled to the cooling device and configured to provide instructions to the one or more cooling elements in response to information regarding at least one of a number of calories ingested by the vertebrate subject or a type and quantity of food ingested by the vertebrate subject. - View Dependent Claims (45, 46)
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Specification