Methods and systems for lowering blood pressure through reduction of ventricle filling
First Claim
1. A system for reducing blood pressure comprising:
- at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and
at least one controller configured to;
receive input relating to the patient'"'"'s blood pressure; and
adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure,wherein the stimulation pattern is configured to cause a reduction in blood pressure by at least a predetermined amount within about 3 seconds from application of electricity of the stimulation pattern to the heart, and to maintain the reduction in blood pressure for a time interval of at least 1 minute.
4 Assignments
0 Petitions
Accused Products
Abstract
Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient'"'"'s heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient'"'"'s heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.
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Citations
33 Claims
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1. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; and adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure, wherein the stimulation pattern is configured to cause a reduction in blood pressure by at least a predetermined amount within about 3 seconds from application of electricity of the stimulation pattern to the heart, and to maintain the reduction in blood pressure for a time interval of at least 1 minute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; and adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure, wherein the controller is configured to adjust the stimulation pattern by performing an adjustment process that includes adjusting a parameter of a first stimulation setting of at least one of the at least one stimulation pulse, and wherein the first stimulation setting is configured to reduce or prevent atrial kick in at least one ventricle. - View Dependent Claims (19, 20)
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21. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; and adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure, wherein the controller is configured to adjust the stimulation pattern by performing an adjustment process that includes adjusting a parameter of a first stimulation setting of at least one of the at least one stimulation pulse, and wherein the adjusted stimulation pattern causes a reduction in blood pressure by at least a predetermined amount within a range of about 1 second and about 3 seconds after application of electricity of the adjusted stimulation pattern to the heart.
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22. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; and adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure, wherein the controller is configured to adjust the stimulation pattern by performing an adjustment process that includes adjusting a parameter of a first stimulation setting of at least one of the at least one stimulation pulse, and wherein the adjusted stimulation pattern causes a reduction in blood pressure within 1, 3, or 5 heartbeats of application of electricity of the adjusted stimulation pattern to the heart.
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23. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure; execute a plurality of stimulation patterns and receive for each of the stimulation patterns a corresponding input data set relating to the patient'"'"'s blood pressure during the each stimulation pattern; calculate for each of the plurality of stimulation patterns at least one blood pressure variation parameter relating to the input data set; adjust the stimulation pattern according to the at least one blood pressure variation parameter; and adjust the stimulation pattern to a stimulation pattern that achieves a desired value of a blood pressure variation parameter, wherein the desired value of the blood pressure variation parameter comprises a lowest degree of baroreflex.
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24. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure; execute a plurality of stimulation patterns and receive for each of the stimulation patterns a corresponding input data set relating to the patient'"'"'s blood pressure during the each stimulation pattern; calculate for each of the plurality of stimulation patterns at least one blood pressure variation parameter relating to the input data set; adjust the stimulation pattern according to the at least one blood pressure variation parameter; and adjust the stimulation pattern to a stimulation pattern that achieves a desired value of a blood pressure variation parameter, wherein the desired value of the blood pressure variation parameter comprises a baroreflex within a predetermined range.
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25. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure; execute a plurality of stimulation patterns and receive for each of the stimulation patterns a corresponding input data set relating to the patient'"'"'s blood pressure during the each stimulation pattern; calculate for each of the plurality of stimulation patterns at least one blood pressure variation parameter relating to the input data set; and adjust the stimulation pattern according to the at least one blood pressure variation parameter, wherein at least two stimulation patterns of the plurality of stimulation patterns each comprise at least one stimulation pulse having a stimulation setting configured to reduce or prevent atrial kick in at least one ventricle, and wherein the at least two stimulation patterns differ one from another. - View Dependent Claims (26)
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27. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure; execute a plurality of stimulation patterns and receive for each of the stimulation patterns a corresponding input data set relating to the patient'"'"'s blood pressure during the each stimulation pattern; calculate for each of the plurality of stimulation patterns at least one blood pressure variation parameter relating to the input data set; and adjust the stimulation pattern according to the at least one blood pressure variation parameter, wherein at least two stimulation patterns of the plurality of stimulation patterns differ from another by one or more stimulation settings included within each of the at least two stimulation patterns.
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28. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; and at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure; execute a plurality of stimulation patterns and receive for each of the stimulation patterns a corresponding input data set relating to the patient'"'"'s blood pressure during the each stimulation pattern; calculate for each of the plurality of stimulation patterns at least one blood pressure variation parameter relating to the input data set; and adjust the stimulation pattern according to the at least one blood pressure variation parameter, wherein the plurality of stimulation patterns includes a first stimulation pattern and a second stimulation pattern executed after the first stimulation pattern, the second stimulation pattern having at least one stimulation setting that is set based on an algorithm using blood pressure variation parameters relating to the input data set of the first stimulation pattern.
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29. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pattern comprising at least one stimulation pulse; at least one controller configured to; receive input relating to the patient'"'"'s blood pressure; adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure; execute a plurality of stimulation patterns and receive for each of the stimulation patterns a corresponding input data set relating to the patient'"'"'s blood pressure during the each stimulation pattern; calculate for each of the plurality of stimulation patterns at least one blood pressure variation parameter relating to the input data set; and adjust the stimulation pattern according to the at least one blood pressure variation parameter; and a blood pressure sensor for providing the input data set relating to the patient'"'"'s blood pressure, wherein the blood pressure sensor and the at least one controller are configured to operate at least partially as a closed loop.
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30. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pulse; and a controller; wherein the controller is configured to; provide a first stimulation pattern comprising at least one stimulation setting configured to reduce or prevent atrial kick in at least one ventricle for a first time interval and to receive a first input data set relating to a patient'"'"'s blood pressure during the first time interval; calculate at least one blood pressure variation parameter relating to the first input data set; adjust at least one parameter of the first stimulation pattern to provide a second stimulation pattern comprising a second stimulation setting configured to reduce or prevent atrial kick in at least one ventricle, the second stimulation setting being based upon the at least one blood pressure variation parameter; and provide the second stimulation pattern for a second time interval.
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31. A system for reducing blood pressure comprising:
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at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with a stimulation pulse; and at least one controller configured to execute a stimulation pattern comprising at least one stimulation setting configured to reduce or prevent atrial kick in at least one ventricle, wherein the stimulation pattern is configured to cause in the patient an immediate reduction in blood pressure from an initial blood pressure value to a reduced blood pressure value and to maintain the patient'"'"'s average blood pressure at rest at least 8 mmHg below the initial blood pressure. - View Dependent Claims (32)
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33. A kit for reducing blood pressure comprising:
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at least one device for setting a stimulation pattern for reducing blood pressure, the device comprising; at least one stimulation electrode for stimulating at least one chamber of a heart of a patient with the stimulation pattern, wherein the stimulation pattern comprises at least one stimulation pulse; and a controller for adjusting the stimulation pattern, the controller configured to; receive input relating to the patient'"'"'s blood pressure; and adjust the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure, wherein the stimulation pattern is configured to cause a reduction in blood pressure by at least a predetermined amount within about 3 seconds from application of electricity of the stimulation pattern to the heart, and to maintain the reduction in blood pressure for a time interval of at least 1 minute; and a set of instructions for adjusting the stimulation pattern based on the received input relating to the patient'"'"'s blood pressure.
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Specification