Compact hydraulic manifold structure for shear sensitive fluids
First Claim
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1. A microfluidic device comprising:
- a first network of channels having a plurality of First Channels, each First Channel having a height in the range of about 50 microns to about 500 microns;
a second network of channels having at least one Second Channel complementary to one or more of the First Channels;
a filtration membrane separating the one or more First Channels from the at least one Second Channel;
wherein the plurality of First Channels further comprises;
an input channel forming a primary channel, a plurality of secondary channels, and an outlet channel, wherein the primary channel bifurcates into first and second secondary channels at a first junction, such that a fluid flow rate through the first secondary channel is substantially the same as a fluid flow rate through the second secondary channel, and the total fluid flow rate between the first and second secondary channels is substantially the same as the fluid flow rate through the primary channel;
a first tertiary channel connecting to the first secondary channel at a second junction located at a first distance along the first secondary channel; and
a second tertiary channel connecting to the first secondary channel at a third junction located at a second distance, greater than the first distance, along the first secondary channel, wherein the first secondary channel and the first and second tertiary channels are configured such that flow of fluid through the first secondary channel beyond the second junction is substantially greater than flow of fluid into the first tertiary channel;
wherein at least one of the first and second tertiary channels bifurcates into first and second quaternary channels at a fourth junction, such that a fluid flow rate through the first quaternary channel is substantially the same as a fluid flow rate through the second quaternary channel, and the total fluid flow rate through the first and second quaternary channels is substantially the same as the fluid flow rate through the portion of the at least one tertiary channel between the first secondary channel and the fourth junction, the microfluidic device further comprising a flow divider for dividing fluid flow between the first and second quaternary channels, wherein the flow divider connects walls of the first and second quaternary channels with a curved surface that faces and is convex to the at least one tertiary channel, and the radius of curvature of the convex curved surface is greater than zero and less than the hydraulic diameter of the at least one tertiary channel.
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Abstract
An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
29 Citations
14 Claims
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1. A microfluidic device comprising:
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a first network of channels having a plurality of First Channels, each First Channel having a height in the range of about 50 microns to about 500 microns; a second network of channels having at least one Second Channel complementary to one or more of the First Channels; a filtration membrane separating the one or more First Channels from the at least one Second Channel; wherein the plurality of First Channels further comprises; an input channel forming a primary channel, a plurality of secondary channels, and an outlet channel, wherein the primary channel bifurcates into first and second secondary channels at a first junction, such that a fluid flow rate through the first secondary channel is substantially the same as a fluid flow rate through the second secondary channel, and the total fluid flow rate between the first and second secondary channels is substantially the same as the fluid flow rate through the primary channel; a first tertiary channel connecting to the first secondary channel at a second junction located at a first distance along the first secondary channel; and a second tertiary channel connecting to the first secondary channel at a third junction located at a second distance, greater than the first distance, along the first secondary channel, wherein the first secondary channel and the first and second tertiary channels are configured such that flow of fluid through the first secondary channel beyond the second junction is substantially greater than flow of fluid into the first tertiary channel; wherein at least one of the first and second tertiary channels bifurcates into first and second quaternary channels at a fourth junction, such that a fluid flow rate through the first quaternary channel is substantially the same as a fluid flow rate through the second quaternary channel, and the total fluid flow rate through the first and second quaternary channels is substantially the same as the fluid flow rate through the portion of the at least one tertiary channel between the first secondary channel and the fourth junction, the microfluidic device further comprising a flow divider for dividing fluid flow between the first and second quaternary channels, wherein the flow divider connects walls of the first and second quaternary channels with a curved surface that faces and is convex to the at least one tertiary channel, and the radius of curvature of the convex curved surface is greater than zero and less than the hydraulic diameter of the at least one tertiary channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification