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Composition for long-acting peptide analogs

  • US 9,657,078 B2
  • Filed: 06/15/2015
  • Issued: 05/23/2017
  • Est. Priority Date: 08/03/2007
  • Status: Active Grant
First Claim
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1. A composition comprising a peptide analog having a general formula:

  • A-(Cm)x-peptide, wherein;

    a. Cm is independently selected from(i) Gly,(ii) Ala,(iii) Arg,(iv) Lys,(v) (N)q-Lys, wherein N is any amino acid, q is 0 or 1, and(vi) (N)q-Arg, wherein N is any amino acid, q is 0 or 1;

    b. x is an integer from 3-6;

    c. A is an alkyl group with 6 to 36 carbon units with a linker group selected from carbonyl and amino; and

    d. the peptide comprises glucagon-like peptide (GLP), leptin fragment, gastric inhibitory polypeptide (GIP), epidermal growth factor (EGF) receptor ligand, EGF, transforming growth factor alpha (TGF-alpha), gastrin/cholecystokinin receptor ligand, gastrin, cholecystokinin, auristatin, nisin, insulin, insulin-like growth factor, parathyroid hormone (PTH), atrial natriuretic factor, somatostatin, gonadotropin-releasing hormone, luteinizing-hormone-releasing-hormone, or vasoactive intestinal peptide (VIP).

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