Anti-glucagon antibodies
First Claim
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1. An isolated antibody or antigen-binding fragment thereof that specifically binds to glucagon (GCG) and neutralizes GCG activity, wherein the antibody or antigen-binding fragment thereof comprises:
- (a) three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) amino acid sequence selected from the group consisting of SEQ ID NOs;
2, 18, 34, 50, 66, 82, 98, 114, 130 and 146; and
(b) three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within a light chain variable region (LCVR) amino acid sequence selected from the group consisting of SEQ ID NOs;
10, 26, 42, 58, 74, 90, 106, 122, 138 and 154.
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Abstract
The present invention provides antibodies that bind to glucagon and methods of using the same. According to certain embodiments, the antibodies of the invention bind human GCG with high affinity. The antibodies of the invention may be fully human antibodies. The antibodies of the invention are useful for the treatment of various diseases or disorders characterized by elevated blood glucose levels, as well as other GCG-related disorders.
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Citations
14 Claims
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1. An isolated antibody or antigen-binding fragment thereof that specifically binds to glucagon (GCG) and neutralizes GCG activity, wherein the antibody or antigen-binding fragment thereof comprises:
- (a) three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) amino acid sequence selected from the group consisting of SEQ ID NOs;
2, 18, 34, 50, 66, 82, 98, 114, 130 and 146; and
(b) three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within a light chain variable region (LCVR) amino acid sequence selected from the group consisting of SEQ ID NOs;
10, 26, 42, 58, 74, 90, 106, 122, 138 and 154. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- (a) three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) amino acid sequence selected from the group consisting of SEQ ID NOs;
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13. An isolated antibody or antigen-binding fragment thereof that competes for specific binding to GCG with an antibody or antigen-binding fragment comprising heavy and light chain sequence pairs selected from the group consisting of SEQ ID NOs:
- 2/10;
18/26;
34/42;
50/58;
66/74;
82/90;
98/106;
114/122;
130/138 and 146/154.
- 2/10;
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14. An isolated antibody or antigen-binding fragment thereof that binds to the same epitope on GCG as a reference antibody comprising an HCVR/LCVR amino acid sequence pair selected from the group consisting of SEQ ID NOs:
- 2/10;
18/26;
34/42;
50/58;
66/74;
82/90;
98/106;
114/122;
130/138 and 146/154.
- 2/10;
Specification