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Anti-glucagon antibodies

  • US 9,657,099 B2
  • Filed: 09/15/2015
  • Issued: 05/23/2017
  • Est. Priority Date: 09/16/2014
  • Status: Active Grant
First Claim
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1. An isolated antibody or antigen-binding fragment thereof that specifically binds to glucagon (GCG) and neutralizes GCG activity, wherein the antibody or antigen-binding fragment thereof comprises:

  • (a) three heavy chain complementarity determining regions (HCDR1, HCDR2 and HCDR3) contained within a heavy chain variable region (HCVR) amino acid sequence selected from the group consisting of SEQ ID NOs;

    2, 18, 34, 50, 66, 82, 98, 114, 130 and 146; and

    (b) three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within a light chain variable region (LCVR) amino acid sequence selected from the group consisting of SEQ ID NOs;

    10, 26, 42, 58, 74, 90, 106, 122, 138 and 154.

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