Method for measuring concentration of analyte in blood sample, and biosensor system
First Claim
1. A method for measuring a concentration of an analyte in a blood sample using a sensor chip, the sensor chip including a capillary and a pair of electrodes, the method including:
- acquiring data a related to a temperature of the blood sample, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result;
acquiring data b related to the concentration of the analyte, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and
measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b, whereinthe first voltage is between 1.0V and 3.0V, and the second voltage is between 0.05V and 1.0V.
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Abstract
The method includes: acquiring data a related to a temperature of a blood sample on a sensor chip, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result; acquiring data b related to the concentration of an analyte in the blood sample, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b.
20 Citations
13 Claims
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1. A method for measuring a concentration of an analyte in a blood sample using a sensor chip, the sensor chip including a capillary and a pair of electrodes, the method including:
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acquiring data a related to a temperature of the blood sample, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result; acquiring data b related to the concentration of the analyte, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b, wherein the first voltage is between 1.0V and 3.0V, and the second voltage is between 0.05V and 1.0V. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for measuring a concentration of an analyte in a blood sample using a sensor chip, the sensor chip including a capillary and a pair of electrodes, the method including:
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acquiring data a related to a temperature of the blood sample, based on a dimension of a current flowing in the blood sample by applying a first voltage to the pair of electrodes in contact with the blood sample, the first voltage being set so as to reduce an effect of hematocrit on a temperature measurement result; acquiring data b related to the concentration of the analyte, based on a dimension of a current flowing in the blood sample by applying a second voltage that is equal to or less than the first voltage, utilizing a reaction mediated by an oxidoreductase that uses the analyte in the blood sample as a substrate; and measuring a concentration that determines the analyte concentration in the blood sample based on the data a and the data b, wherein the data a related to the temperature of the blood sample contains a temperature, and the data b related to the concentration of the analyte contains a glucose concentration. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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Specification
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- Resources
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Current AssigneePHC Holdings Corporation
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Original AssigneePanasonic Healthcare Holdings Co., Ltd.
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InventorsUchiyama, Motonori
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Primary Examiner(s)Ball, J. Christopher
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Application NumberUS14/230,221Publication NumberTime in Patent Office1,149 DaysField of SearchUS Class CurrentCPC Class CodesG01N 27/3274 Corrective measures, e.g. e...G01N 33/49 Blood chemical methods for ...
