Methods and devices for detection of analytes using bloch surface wave-enhanced diffraction-based sensors
First Claim
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1. A device for the detection of an analyte in a sample comprising:
- (a) a diffraction grating comprising an immobilized binding agent capable of binding said analyte, and(b) a periodic dielectric multilayer, wherein said immobilized binding agent is immobilized on the surface of said periodic dielectric multilayer,wherein Bloch surface waves are capable of propagating at the surface of said periodic dielectric multilayer, thereby enhancing diffraction from said diffraction grating.
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Abstract
The invention features methods and diffraction-based devices for the detection of specific analytes. The devices of the invention contain a periodic dielectric multilayer, which allows for the propagation of Bloch surface waves (BSWs) at the surface of the multilayer, thereby increasing the sensitivity of the device.
15 Citations
32 Claims
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1. A device for the detection of an analyte in a sample comprising:
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(a) a diffraction grating comprising an immobilized binding agent capable of binding said analyte, and (b) a periodic dielectric multilayer, wherein said immobilized binding agent is immobilized on the surface of said periodic dielectric multilayer, wherein Bloch surface waves are capable of propagating at the surface of said periodic dielectric multilayer, thereby enhancing diffraction from said diffraction grating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A diffraction-based device comprising:
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(a) a diffraction grating comprising chemical groups capable of immobilizing a binding agent capable of binding to an analyte, and (b) a periodic dielectric multilayer, wherein Bloch surface waves are capable of propagating at the surface of said periodic dielectric multilayer, thereby enhancing diffraction from said diffraction grating. - View Dependent Claims (26, 27, 28)
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29. A method for the detection of an analyte in a sample comprising:
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(a) providing a device comprising;
(i) a diffraction grating comprising an immobilized binding agent capable of binding said analyte, and (ii) a periodic dielectric multilayer, wherein said immobilized binding agent is immobilized on the surface of said periodic dielectric multilayer;(b) contacting the device with said sample, so analyte in said sample binds to said immobilized binding agent; and (c) detecting said analyte by Bloch surface wave-enhanced optical diffraction associated with said analyte binding to said immobilized binding agent. - View Dependent Claims (30)
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31. A method for the detection of an analyte in a sample comprising:
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(a) providing a device comprising (i) a diffraction grating comprising chemical groups capable of immobilizing a binding agent capable of binding to an analyte, and (ii) a periodic dielectric multilayer, wherein Bloch surface waves are capable of propagating at the surface of said periodic dielectric multilayer, thereby enhancing diffraction from said diffraction grating; (b) contacting the device with a binding agent, so said binding agent binds to said chemical groups to immobilize said binding agent; (c) contacting the device of (b) with said sample, so analyte in said sample binds to said immobilized binding agent; and (d) detecting said analyte by Bloch surface wave-enhanced optical diffraction associated with said analyte binding to said immobilized binding agent. - View Dependent Claims (32)
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Specification